Quality by Design: Multidimensional exploration of the design space in high performance liquid chromatography method development for better robustness before validation

Journal of Chromatography A

Volumn 1232, Issue , 2012, Pages 218-230

  Monks, K ^a   Molnar I ^a   Rieger, H J ^a   Bogati B ^b   Szabo E ^b  

^a Molnár Institute for Applied Chromatography   (Germany)

^b TEVA Pharmaceutical Works Private Limited Company   (Hungary)

Author keywords

Chromatography modeling software; Design space; Quality by Design (QbD); Robustness; Validation

Indexed keywords

DESIGN SPACE; DESIGN SPACES; EYE DROPS; HPLC SEPARATION; METHOD DEVELOPMENT; MODELING SOFTWARES; QUALITY BY DESIGN (QBD); QUALITY BY DESIGNS; VALIDATION;

CHROMATOGRAPHY; DESIGN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ROBUSTNESS (CONTROL SYSTEMS);

QUALITY CONTROL;

ACCURACY; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFORMATION PROCESSING; MATHEMATICAL ANALYSIS; PH; PRIORITY JOURNAL; QUALITY BY DESIGN; QUALITY CONTROL PROCEDURES; SPACE; TEMPERATURE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MODELS, THEORETICAL; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; SOFTWARE; USER-COMPUTER INTERFACE;

APIS;

EID: 84858079402     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.12.041     Document Type: Article

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