A stepwise strategy employing automated screening and DryLab modeling for the development of robust methods for challenging high performance liquid chromatography separations: A case study

Analytica Chimica Acta

Volumn 696, Issue 1-2, 2011, Pages 116-124

  Jayaraman, K ^a   Alexander, A J ^a   Hu, Y ^a   Tomasella, F P ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Column screening system; DryLab ; Method development strategy; Method optimization

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; AUTOMATED SCREENING; CHROMATOGRAPHIC SEPARATIONS; EXPERIMENTAL VERIFICATION; HPLC METHOD; IMPURITIES IN; METHOD DEVELOPMENT; METHOD OPTIMIZATION; OPTIMIZED GRADIENTS; REASONABLE ACCURACY; ROBUST METHODS; SCREENING SYSTEM; SEPARATION CONDITION; STEPWISE METHODS;

AUTOMATION; DRUG PRODUCTS; FORECASTING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERS; OPTIMIZATION; STRATEGIC PLANNING;

CHROMATOGRAPHY;

DAPAGLIFLOZIN;

ACCURACY; ARTICLE; AUTOMATION; CHEMICAL STRUCTURE; COMPUTER PREDICTION; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG IMPURITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCREENING TEST; SEPARATION TECHNIQUE; TEMPERATURE SENSITIVITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; DRUG CONTAMINATION; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; SOFTWARE; TEMPERATURE;

EID: 79957512754     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2011.04.010     Document Type: Article

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