Toxicity and retinal penetration of infliximab in primates

Retina

Volumn 32, Issue 3, 2012, Pages 606-612

  Melo, Gustavo B ^a   Moraes Filho, Milton N ^a   Rodrigues, Eduardo B ^a   Regatieri, Caio V ^a   Dreyfuss, Juliana L ^a   Penha, Fernando M ^a   Pinheiro, Marcelo M ^a   Coimbra, Rita C S G ^a   Haapalainen, Edna F ^a   Farah, Michel E ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; INFLIXIMAB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B WAVE; CALLITHRIX; CONTROLLED STUDY; DRUG PENETRATION; ELECTRORETINOGRAPHY; EYE TOXICITY; IMMUNOHISTOCHEMISTRY; MICROSCOPY; NONHUMAN; RETINA TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; CALLITHRIX; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; IMMUNOHISTOCHEMISTRY; INTRAVITREAL INJECTIONS; MICROSCOPY; RETINA; RETINAL DISEASES;

EID: 84858077030     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0b013e3182252a23     Document Type: Article

References (17)

1. Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumor-necrosis factor-alpha from cells. Nature 1997;385:729-733. (Pubitemid 27098094)
2. Wallach D, Varfolomeev EE, Malinin NL, et al. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol 1999;17:331-367. (Pubitemid 29241128)
3. Majka S, McGuire PG, Das A. Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization. Invest Ophthalmol Vis Sci 2002;43:260-266. (Pubitemid 34032468)
4. Penfold PL, Madigan MC, Gillies MC, Provis JM. Immunological and aetiological aspects of macular degeneration. Prog Retin Eye Res 2001;20:385-414. (Pubitemid 32245687)
5. Sakurai E, Anand A, Ambati BK, et al. Macrophage depletion inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci 2003;44:3578-3585. (Pubitemid 36909798)
6. Oh H, Takagi H, Takagi C, et al. The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes. Invest Ophthalmol Vis Sci 1999;40: 1891-1898. (Pubitemid 29365148)
7. Regatieri CV, Dreyfuss JL, Melo GB, et al. Dual role of intravitreous infliximab in experimental choroidal neovascularization: effect on the expression of sulfated glycosaminoglycans. Invest Ophthalmol Vis Sci 2009;50:5487-5494.
8. Giansanti F, Ramazzotti M, Vannozzi L, et al. A pilot study on ocular safety of intravitreal infliximab in a rabbit model. Invest Ophthalmol Vis Sci 2008;49:1151-1156.
9. Theodossiadis PG, Liarakos VS, Sfikakis PP, et al. Intravitreal administration of the anti-TNF monoclonal antibody infliximab in the rabbit. Graefes Arch Clin Exp Ophthalmol 2009; 247:273-281.
10. Giganti M, Beer PM, Lemanski N, et al. Adverse events after intravitreal infliximab (Remicade). Retina 2010;30:71-80.
11. Theodossiadis PG, Liarakos VS, Sfikakis PP, et al. Intravitreal administration of the anti-tumor necrosis factor agent infliximab for neovascular age-related macular degeneration. Am J Ophthalmol 2009;147:825-830, 830.e1.
12. Rodrigues EB, Penha FM, Farah ME, et al. Preclinical investigation of the retinal biocompatibility of six novel vital dyes for chromovitrectomy. Retina 2009;29:497-510.
13. Penha FM, Rodrigues EB, Maia M, et al. Retinal and ocular toxicity in ocular application of drugs and chemicals-part I: animal models and toxicity assays. Ophthalmic Res 2010;44: 82-104.
14. Hendrickson A, Troilo D, Possin D, Springer A. Development of the neural retina and its vasculature in the marmoset Callithrix jacchus. J Comp Neurol 2006;497:270-286. (Pubitemid 43825431)
15. Troilo D, Quinn N, Baker K. Accommodation and induced myopia in marmosets. Vision Res 2007;47:1228-1244. (Pubitemid 46482632)
16. Braun J, Baraliakos X, Listing J, Sieper J. Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept. Arthritis Rheum 2005;52:2447-2551.
17. Heiduschka P, Fietz H, Hofmeister S, et al. Penetration of bevacizumab through the retina after intravitreal injection in the monkey. Invest Ophthalmol Vis Sci 2007;48:2814-2823. (Pubitemid 351261238)