Investigation of lysine acrylate containing poly(N-isopropylacrylamide) hydrogels as wound dressings in normal and infected wounds

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 100 B, Issue 3, 2012, Pages 668-676

  Jiang, Bin ^a,b   Larson, Jeffery C ^a,b   Drapala, Pawel W ^a   Pérez Luna, Víctor H ^a   Kang Mieler, Jennifer J ^a   Brey, Eric M ^a,b  

^a Illinois Institute of Technology   (United States)

^b Jr VA Hospital   (United States)

Author keywords

antimicrobial agents; hydrogels; poly(N isopropylacrylamide); wound dressings; wound infection

Indexed keywords

ANTI-MICROBIAL AGENT; ANTIMICROBIAL DRUG; BIOACTIVE MATERIAL; BIOMEDICAL APPLICATIONS; CELL INTERACTION; CELLULAR INTERACTION; CROSSLINKED; CUTANEOUS WOUNDS; IN-VITRO; IN-VIVO; INFECTED WOUNDS; N-ISOPROPYLACRYLAMIDES; PNIPAAM; PNIPAAM HYDROGELS; POLY HYDROGELS; POLY-N-ISOPROPYL ACRYLAMIDE; POLYHEXAMETHYLENE BIGUANIDE; SKIN REGENERATION; SWELLING PROPERTIES; THERMORESPONSIVE BEHAVIOR; WOUND DRESSINGS; WOUND INFECTION;

ACRYLIC MONOMERS; AMINO ACIDS; BIOACTIVITY; BIOMATERIALS; DESIGN; DRUG DELIVERY; MEDICAL APPLICATIONS; MICROORGANISMS; POLYETHYLENE GLYCOLS; SWELLING;

HYDROGELS;

ACRYLIC ACID DERIVATIVE; ACRYOYLLYSINE; MACROGOL; POLY(HEXAMETHYLENEBIGUANIDE); POLY(N ISOPROPYLACRYLAMIDE); UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL ADHESION; CELL INTERACTION; CONTROLLED STUDY; CROSS LINKING; DRUG RELEASE; FIBROBLAST; HYDROGEL; MALE; MOUSE; NONHUMAN; PHASE TRANSITION; RAT; TRANSITION TEMPERATURE; WOUND DRESSING; WOUND HEALING; WOUND INFECTION;

ACRYLAMIDES; ACRYLATES; ANIMALS; ANTI-BACTERIAL AGENTS; BANDAGES; BIGUANIDES; DISINFECTANTS; HYDROGELS; LYSINE; MALE; MICE; NIH 3T3 CELLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; WOUND HEALING; WOUND INFECTION;

EID: 84858069864     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31991     Document Type: Article

References (24)

1. Dale J,. Wound dressings. Prof Nurse 1997; 12 (12 Suppl): s12-s14.
2. Wiseman DM, Rovee DT, Alvarez OM,. Wound dressings: design and use. In:, Cohen IK, Diegelmann RF, Linndblad WJ, editors. Wound Healing: Biochemical and Clinical Aspects. Philadelphia: WB Saunders; 1992. p 562-580.
3. Ovington L,. The art and science of wound dressings in the twenty-first century. In:, Falabella AF, Kirsner RS, editors. Wound Healing. Boca Raton: Taylor & Francis Group; 2005. p 587-598.
4. Drosou A, Falabella A, Kirsner RS,. Antiseptics on wound: an area of controversy. Wounds 2003; 15: 149-166.
5. Martin LK, Drosou A, Kirsner RS,. Wound microbiology and the use of antibacterial agents. In:, Falabella AF, Kirsner RS, editors. Wound Healing. Boca Raton: Taylor & Francis Group; 2005. p 83-102.
6. Ignacio C, Barcellos L, Ferreira MD, Moura SA, Soares IA, Oréfice RL,. In vivo tests of a novel wound dressing based on biomaterials with tissue adhesion controlled through external stimuli. J Mater Sci Mater Med 2011; 22: 1357-1364.
7. Hoffman AS,. Applications of "smart polymers" as biomaterials. In:, Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, editors. Biomaterials Science: An Introduction to Materials in Medicine, 2nd ed. San Diego: Elsevier Academic Press; 2004: p 107-115.
8. Turturro SB, Guthrie MJ, Appel AA, Drapala PW, Brey EM, Pérez-Luna VH, Mieler WF, Kang-Mieler JJ,. The effects of cross-linked thermo-responsive PNIPAAm-based hydrogel injection on retinal function. Biomaterials 2011; 32: 3620-3626.
9. Drapala PW, Brey EM, Mieler WF, Venerus DC, Kang Derwent JJ, Pérez-Luna VH,. Role of thermo-responsiveness and poly(ethylene glycol) diacrylate cross-link density on protein release from poly(N- isopropylacrylamide) Hydrogels. J Biomater Sci Polym Ed 2011; 22: 59-75.
10. Wang J, Chen L, Zhao Y, Guo G, Zhang R,. Cell adhesion and accelerated detachment on the surface of temperature-sensitive chitosan and poly(N-isopropylacrylamide) hydrogels. J Mater Sci Mater Med 2009; 20: 583-590.
11. Liu H, Ito Y,. Cell attachment and detachment on micropattern-immobilized poly(N-isopropylacrylamide) with gelatin. Lab Chip 2002; 2: 175-178. (Pubitemid 37254498)
12. Fitzpatrick SD, Jafar Mazumder MA, Lasowski F, Fitzpatrick LE, Sheardown H,. PNIPAAm-grafted-collagen as an injectable, in situ gelling, bioactive cell delivery scaffold. Biomacromolecules 2010; 11: 2261-2267.
13. Reddy TT, Kano A, Maruyama A, Hadano M, Takahara A,. Thermosensitive transparent semi-interpenetrating polymer networks for wound dressing and cell adhesion control. Biomacromolecules 2008; 9: 1313-1321. (Pubitemid 351639587)
14. Peng H, Xiao Y, Mao X, Chen L, Crawford R, Whittaker AK,. Amphiphilic triblock copolymers of methoxy-poly (ethylene glycol)-b-poly (L -lactide)-b-poly (L -lysine) for enhancement of osteoblast attachment and growth. Biomacromolecules 2009; 10: 95-104.
15. Xue W, Champ S, Huglin MB,. Network and swelling parameters of chemically crosslinked thermoreversible hydrogels. Polymer 2001; 42: 3665-3669.
16. Andrews JM,. Determination of minimum inhibitory concentrations. J Antimicrob Chemother 2001; 48 (Suppl S1): 5-16.
17. Lyczak JB, Cannon CL, Pier GB,. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect 2000: 2: 1051-1060 (Pubitemid 30664219)
18. Hoffman AS, Stayton PS, Bulmus V, Chen G, Chen J, Cheung C, Chilkoti A, Ding Z, Dong L, Fong R, Lackey CA, Long CJ, Miura M, Morris JE, Murthy N, Nabeshima Y, Park TG, Press OW, Shimoboji T, Shoemaker S, Yang HJ, Monji N, Nowinski RC, Cole CA, Priest JH, Harris JM, Nakamae K, Nishino T, Miyata T,. Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI, May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins. J Biomed Mater Res 2000; 52: 577-586.
19. Allen MJ, White GF, Morby AP,. The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide. Microbiology 2006; 52 (pt 4): 989-1000.
20. Chen JP, Lee WL,. Collagen-grafted temperature-responsive nonwoven fabric for wound dressing. Appl Surf Sci 2008; 255: 412-415.
21. Yang JM, Yang SJ, Lin HT, Wu TH, Chen HJ,. Chitosan containing PU/Poly(NIPAAm) thermosensitive membrane for wound dressing. Mater Sci Eng C 2008; 28: 150-156. (Pubitemid 350297884)
22. Mulder GD, Cavorsi JP, Lee DK,. Polyhexamethylene biguanide (PHMB): An addendum to current topical antimicrobials. Wounds 2007; 19: 173-182.
23. Saatman RA, Carlton WW, Hubben K, Street CS, Tuckosh J, Debaecke PJ,. A wound healing study of chlorhexidine digluconate in guinea pigs. Fundam Appl Toxicol 1986; 6: 1-6. (Pubitemid 16177742)
24. Sabnis A, Wadajkar AS, Aswath P, Nguyen KT,. Factorial analyses of photopolymerizable thermoresponsive composite hydrogels for protein delivery. Nanomedicine 2009; 5: 305-315.