Factorial analyses of photopolymerizable thermoresponsive composite hydrogels for protein delivery

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 5, Issue 3, 2009, Pages 305-315

  Sabnis, Abhimanyu ^a   Wadajkar, Aniket S ^a   Aswath, Pranesh ^b   Nguyen, Kytai T ^a  

^a University of Texas at Arlington   (United States)

^b UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

Factorial analysis; Hydrogel; Photopolymerization; Thermoresponsiveness

Indexed keywords

ACRYLAMIDES; BURST RELEASE; COMPOSITE HYDROGELS; COMPOSITE NANOPARTICLES; FACTORIAL ANALYSIS; HYDROGEL SWELLING; IN-SITU; MATRIX; N-ISOPROPYLACRYLAMIDES; NANOPARTICLE CONCENTRATIONS; PHOTO-INITIATOR; PLATEAU REGION; POLYETHYLENE GLYCOL DIACRYLATE; PROTEIN DELIVERY; PROTEIN DELIVERY SYSTEMS; PROTEIN RELEASE; RELEASE PROFILES; SUSTAINED RELEASE; SWELLING RATIO; TEMPERATURE-RESPONSIVE; TEMPERATURE-SENSITIVE; THERMO-RESPONSIVE; THERMORESPONSIVENESS; ULTRA-VIOLET LIGHT; WOUND HEALING APPLICATIONS;

ACRYLIC MONOMERS; AMIDES; COMPOSITE MATERIALS; ETHYLENE; ETHYLENE GLYCOL; NANOPARTICLES; PHOTOPOLYMERIZATION; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SWELLING; ULTRAVIOLET RADIATION;

HYDROGELS;

POLY(ETHYLENE GLYCOL) DIACRYLATE; POLY(N ISOPROPYLACRYLAMIDE CO ACRYLAMIDE); UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); FACTORIAL ANALYSIS; HEAT SENSITIVITY; HYDROGEL; INJURY; MOLECULAR WEIGHT; PROTEIN SECRETION; TEMPERATURE SENSITIVITY; ULTRAVIOLET RADIATION; WOUND HEALING;

ACRYLIC RESINS; DRUG DELIVERY SYSTEMS; FACTOR ANALYSIS, STATISTICAL; HYDROGELS; LIGHT; NANOPARTICLES; POLYETHYLENE GLYCOLS; PROTEINS; TEMPERATURE;

EID: 69249228547     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2008.11.003     Document Type: Article

References (40)

1. Ramanan R., Chellamuthu P., Tang L., and Nguyen K. Development of a temperature-sensitive composite hydrogel for drug delivery applications. Biotechnol Prog 22 (2006) 118-125
2. Quick D., and Anseth K. DNA delivery from photocrosslinked PEG hydrogels: encapsulation efficiency, release profiles, and DNA quality. J Control Release 96 (2004) 341-351
3. Mellott M.B., Searcy K., and Pishko M.V. Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization. Biomaterials 22 (2001) 929-941
4. Elisseeff J., McIntosh W., Anseth K., Riley S., Ragan P., and Langer R. Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. J Biomed Mater Res 51 (2000) 164-171
5. Bryant S., and Anseth K. The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) hydrogels. Biomaterials 22 (2001) 619-626
6. Masters K., Leibovich S., Belem P., West J., and Poole-Warren L. Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressing on dermal wound healing in diabetic mice. Wound Repair Regen 10 (2002) 286-294
7. Fisher J., Dean D., and Mikos A. Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly(propylene fumarate) biomaterials. Biomaterials 23 (2002) 4333-4343
8. Yang F., Williams C., Wang D., Lee H., Manson P., and Elisseeff J. The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells. Biomaterials 26 (2005) 5991-5998
9. Cruise G., Hegre O., Scharp D., and Hubbell J. A sensitivity study of the key parameters in the interfacial photopolymerization of the poly(ethylene glycol) diacrylate upon porcine islets. Biotechnol Bioeng 57 (1998) 655-665
10. Cruise G., Hegre O., Lamberti F., Hager S., Hill R., Scharp D., et al. In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes. Cell Transplant 8 (2000) 293-306
11. Burdick J., and Anseth K. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 23 (2002) 4315-4323
12. Bryant S., Chowdhury T., Lee D., Bader D., and Anseth K. Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng 32 (2004) 407-417
13. Gonzalez A., Gobin A., West J., McIntire L., and Smith C. Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels. Tissue Eng 10 (2004) 1775-1785
14. Kizilel S., Pérez-Luna V., and Teymour F. Photopolymerization of poly(ethylene glycol) diacrylate on eosin-functionalized surfaces. Langmuir 20 (2004) 8652-8658
15. Leach J.B., and Schmidt C.E. Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffolds. Biomaterials 26 (2005) 125-135
16. Masters K., Lipke E., Rice E., Liel M., Myler H., Zygourakis C., et al. Nitric oxide-generating hydrogels inhibit neointima formation. J Biomater Sci Polym Ed 16 (2005) 659-672
17. Kopecek J., and Yang J. Hydrogels as smart biomaterials. Polym Int 56 (2007) 1078-1098
18. Ito S., and Ronbunshu K. Phase transition of aqueous solution of poly(N-isopropylacrylamide) derivatives-effects of side chain structure. CSA Illumina 46 (1989) 437-443
19. Kavanagh C., Rochev Y., Gallagher W., Dawson K., and Keenan A. Local drug delivery in restenosis injury: thermoresponsive co-polymers as potential drug delivery systems. Pharmacol Ther 102 (2004) 1-15
20. Luscher T., Steffel J., Eberli F., Joner M., Nakazawa G., Tanner F., et al. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation 115 (2007) 1051-1058
21. Leon M. Late thrombosis a concern with drug-eluting stents. J Interv Cardiol 20 (2007) 26-29
22. Wenaweser P., Dorffler-Melly J., Imboden K., Windecker S., Togni M., Meier B., et al. Stent thrombosis is associated with an impaired response to antiplatelet therapy. J Am Coll Cardiol 45 (2005) 1748-1752
23. Braddock M., Campbell C., and Zuder D. Current therapies for wound healing: electrical stimulation, biological therapeutics, and the potential for gene therapy. Int J Dermatol 38 (1999) 808-817
24. Indolfi C., Coppola C., Torella D., Arcucci O., and Chiariello M. Gene therapy for restenosis after balloon angioplasty and stenting. Cardiol Rev 7 (1999) 324-331
25. Ishihara M., Nakanishi K., Ono K., Sato M., Kikuchi M., Saito Y., et al. Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process. Biomaterials 23 (2002) 833-840
26. Shen Z., Terao K., Maki Y., Dobashi T., Ma G., and Yamamoto T. Synthesis and phase behavior of aqueous poly(N-isopropylacrylamide-co-acrylamide), poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) and poly(N-isopropylacrylamide-co-2-hydroxyethylmethacrylate). Colloid Polym Sci 284 (2006) 1001-1007
27. Bae Y.H., Okano T., Hsu R., and Kim S.W. Thermo-sensitive polymers as on-off switches for drug release. Die Makromolekulare Chemie 8 (1987) 481-485
28. Bae Y.H., Okano T., and Kim S.W. "On-off" thermocontrol of solute transport. II. Solute release from thermosensitive hydrogels. Pharm Res 8 (1991) 624-628
29. Hoffman A.S. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Control Release 6 (1987) 297-305
30. Hoffman A.S., Stayton P.S., Bulmus V., Chen G., Chen J., Cheung C., et al. Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, Hawaii, 15-20 May 2000. Really smart bioconjugates of smart polymers and receptor proteins. J Biomed Mater Res 52 (2000) 577-586
31. Huang G., Gao J., Hu Z., St John J.V., Ponder B.C., and Moro D. Controlled drug release from hydrogel nanoparticle networks. J Control Release 94 (2004) 303-311
32. Xia X., Hu Z., and Marquez M. Physically bonded nanoparticle networks: a novel drug delivery system. J Control Release 103 (2005) 21-30
33. Waltera E., Moelling K., Pavlovic J., and Merkle H.P. Microencapsulation of DNA using poly(dl-lactide-co-glycolide): stability issues and release characteristics. J Control Release 61 (1999) 361-374
34. DeLong S., Moon J., and West J. Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. Biomaterials 26 (2005) 3227-3234
35. Nuttelman C., Tripodi M., and Anseth K. In vitro osteogenic differentiation of human mesenchymal stem cells photoencapsulated in PEG hydrogels. J Biomed Mater Res A 68 (2004) 773-782
36. Caykara T., Kiper S., and Demirel G. Thermosensitive poly(N-isopropylacrylamide-co-acrylamide) hydrogels: synthesis, swelling and interaction with ionic surfactants. Eur Poly J 42 (2006) 348-355
37. Sabnis A., Chapman C., Rahimi M., and Nguyen K.T. Cytocompatibility studies of an in situ photopolymerized thermoresponsive hydrogel nanoparticle system using human aortic smooth muscle cells. J Biomed Mater Res A (2009) [in press]
38. Ghosh K., Shu X., Mou R., Lombardi J., Prestwich G., Rafailovich M., et al. Rheological characterization of in situ cross-linkable hyaluronan hydrogels. Biomacromolecules 6 (2005) 2857-2865
39. Kim S.W., Bae Y.H., and Okano T. Hydrogels: swelling, drug loading, and release. Pharm Res 9 (1992) 283-290
40. DiRamio J., Kisaalita W., Majetich G., and Shimkus J. Poly(ethylene glycol) methacrylate/dimethacrylate hydrogels for controlled release of hydrophobic drugs. Biotechnol Prog 21 (2005) 1281-1288