The relationship between serum ghrelin and body composition with bone mineral density and QUS parameters in subjects with Rett syndrome

Bone

Volumn 50, Issue 4, 2012, Pages 830-835

  Caffarelli, C ^a   Gonnelli, S ^a   Tanzilli, L ^a   Hayek, J ^b   Vichi, V ^a   Franci, M B ^a   Lucani, B ^a   Nuti, R ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY HOSPITAL OF SIENA   (Italy)

Author keywords

BMD WB; Fat mass; Ghrelin; Lean mass; Quantitative ultrasound; Rett's syndrome

Indexed keywords

GHRELIN;

ADOLESCENT; ADULT; AGE; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY COMPOSITION; BODY HEIGHT; BONE MINERAL; CHILD; CONTROLLED STUDY; DENSITOMETRY; DUAL ENERGY X RAY ABSORPTIOMETRY; ECHOGRAPHY; FAT MASS; FAT PERCENTAGE; FEMALE; GHRELIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; LEAN MASS; MAJOR CLINICAL STUDY; PHALANX; PRESCHOOL CHILD; RETT SYNDROME; SCHOOL CHILD; ULTRASOUND SCANNER;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; ADULT; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DENSITOMETRY; FEMALE; FINGER PHALANGES; GHRELIN; HUMANS; LINEAR MODELS; MALE; RETT SYNDROME; WALKING; YOUNG ADULT;

EID: 84858035442     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.01.017     Document Type: Article

References (46)

1. Chahrour M., Zoghb H.Y. The story of Rett syndrome: from clinic to neurobiology. Neuron 2007, 56:422-437.
2. Moser S.J., Weber P., Lutschg J. Rett syndrome: clinical and electrophysiologic aspects. Pediatr Neurol 2007, 36:95-100.
3. Leonard H., Thompson M., Glasson E., Fyfe S., Leonard S., Ellaway C., et al. Metacarpophalangeal pattern profile and bone age in Rett syndrome: further radiological clues to the diagnosis. Am J Med Genet 1999, 83:88-95.
4. Haas R.H., Dixon S.D., Sartoris D.J., Hennessy M.J. Osteopenia in Rett syndrome. J Pediatr 1997, 131:771-774.
5. Cepollaro C., Gonnelli S., Bruni D., Pacini S., Martini S., Franci M.B., et al. Dual x-ray absorptiometry and bone ultrasonography in patients with Rett syndrome. Calcif Tissue Int 2001, 69:259-262.
6. Ellis K.J., Shypailo R.J., Hardin D.S., Perez M.D., Motil K.J., Wong W.W., et al. Z score prediction model for assessment of bone mineral content in paediatric diseases. J Bone Miner Res 2001, 16:1658-1664.
7. Budden S.S., Gunness M.E. Possible mechanisms of osteopenia in Rett syndrome: bone histomorphometric studies. J Child Neurol 2003, 18:698-702.
8. Motil K.J., Schultz R.J., Abrams S., Ellis K.J., Glaze D.G. Fractional calcium absorption is increased in girls with Rett syndrome. J Pediatr Gastroenterol Nutr 2006, 42:419-426.
9. Motil K.J., Ellis K.J., Barrish J.O., Caeg E., Glaze D.G. Bone mineral content and bone mineral density are lower in older than in younger females with Rett syndrome. Pediatr Res 2008, 64:435-439.
10. Jefferson A.L., Woodhead H.J., Fyfe S., Briody J., Bebbington A., Strauss B.J., et al. Bone mineral content and density in Rett syndrome and their contributing factors. Pediatr Res 2011, 69:293-298.
11. Roende G., Ravn K., Fuglsang K., Andersen H., Nielsen J.B., Brøndum-Nielsen K., et al. DXA-measurements in Rett syndrome reveal small bones with low bone mass. J Bone Miner Res 2011, 26:2280-2286.
12. Roende G., Ravn K., Fuglsang K., Andersen H., Vestergaard A., Brøndum-Nielsen K., et al. Patients with Rett syndrome sustain low-energy fractures. Pediatr Res 2011, 69:359-364.
13. Dorsey K.B., Thornton J.C., heymsfield S.B., Gallagher D. Greater lean tissue and skeletal muscle mass are associated with higher bone mineral content in children. Nutr Metab (Lond) 2010, 7:41.
14. Reid I.R. Relationships among body mass, its components, and bone. Bone 2002, 31:547-555.
15. Reid I.R., Cornish J., Baldock P.A. Nutrition-related peptides and bone homeostasis. J Bone Miner Res 2006, 21:495-500.
16. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
17. Kojima M., Kangawa K. Ghrelin: structure and function. Physiol Rev 2005, 85:495-522.
18. van der Lely A.J., Tschöp M., Heiman M.L., Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004, 25:426-457.
19. Cummings D.E., Weigle D.S., Frayo R.S., Breen P.A., Ma M.K., Dellinger E.P., et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002, 346:1623-1630.
20. Fukushima N., Hanada R., Teranishi H., Fukue Y., Tachibana T., Ishikawa H., et al. Ghrelin directly regulates bone formation. J Bone Miner Res 2005, 20:790-798.
21. Misra M., Miller K.K., Stewart V., Hunter E., Kuo K., Herzog D.B., et al. Ghrelin and bone metabolism in adolescent girls with anorexia nervosa and healthy adolescents. J Clin Endocrinol Metab 2005, 90:5082-5087.
22. Akamizu T., Iwakura H., Ariyasu H., Hosoda H., Murayama T., Yokode M., et al. Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite. Eur J Endocrinol 2008, 158:491-498.
23. Hagberg B., Hanefeld F., Percy A., Skjeldal O. An update on clinically applicable diagnostic criteria in Rett syndrome. Eur J Paediatr Neurol 2002, 6:293-297.
24. Neul J.L., Kaufmann W.E., Glaze D.G., Christodoulou J., Clarke A.J., Bahi-Buisson N., et al. RettSearch Consortium, Rett syndrome: revised diagnostic criteria and nomenclature. Ann Neurol 2010, 68:944-950.
25. Taylor A., Konrad P.T., Norman M.E., Harcke H.T. Total body bone mineral density in young children: influence of head bone mineral density. J Bone Miner Res 1997, 12:652-655.
26. Katzman D.K., Bachrach L.K., Carter D.R., Marcus R. Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab 1991, 73:1332-1339.
27. Wuster C., Albanese C., De Aloysio D., Duboeuf F., Gambacciani M., Gonnelli S., et al. Phalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. J Bone Miner Res 2000, 15:1603-1614.
28. Montagnani A., Gonnelli S., Cepollaro C., Bruni D., Franci M.B., Lucani B., et al. Graphic trace analysis of quantitative ultrasound at phalanxes seems to improve the diagnosis of primary hyperparathyroidism among patients with low bone mass. Osteoporos Int 2002, 13:222-227.
29. Barkmann R., Lusse S., Stampa B., Sakata S., Heller M., Gluer C.C. Assessment of the geometry of human finger phalanges using quantitative ultrasound in vivo. Osteoporos Int 2000, 11:745-755.
30. Baroncelli G.I., Federico G., Vignolo M., Valerio G., Del Puente A., Maghnie M., et al. Cross-sectional reference data for phalangeal quantitative ultrasound from early childhood to young-adulthood according to gender, age, skeletal growth, and pubertal development. Bone 2006, 39:17159-17317.
31. Misra M., Prabhakaran R., Miller K.K., Goldstein M.A., Mickley D., Clauss L., et al. Prognostic indicators of changes in bone density measures in adolescent girls with anorexia nervosa-II. J Clin Endocrinol Metab 2008, 93:1292-1297.
32. Misra M., Miller K.K., Cord J., Prabhakaran R., Herzog D.B., Goldstein M., et al. Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa. J Clin Endocrinol Metab 2007, 92:2046-2052.
33. Altinkaynak S., Selimoglu M.A., Ertekin V., Kilicarslan B. Serum ghrelin levels in children with primary protein-energy malnutrition. Pediatr Int 2008, 50:429-431.
34. Camurdan M.O., Bideci A., Demirel F., Cinaz P. Serum Ghrelin, IGF-I and IGFBP-3 Levels in children with normal variant short stature. Endocr J 2006, 53:479-484.
35. Hara M., Nishi Y., Yamashita Y., Yoh J., Takahashi S., Nagamitsu S.I., et al. Ghrelin levels are reduced in Rett syndrome patients with eating difficulties. Int J Dev Neurosci 2011, 29:899-902.
36. Chanoine J.P. Ghrelin in growth and development. Horm Res 2005, 63:129-138.
37. Whatmore A.J., Hall C.M., Jones J., Westwood M., Clayton P.E. Ghrelin concentrations in healthy children and adolescents. Clin Endocrinol (Oxf) 2003, 59:649-654.
38. Pomerants T., Tillmann V., Jürimäe J., Jürimäe T. The influence of serum ghrelin, IGF axis and testosterone on bone mineral density in boys at different stages of sexual maturity. J Bone Miner Metab 2007, 25:193-197.
39. Farr J.N., Chen Z., Lisse J.R., Lohman T.G., Going S.B. Relationship of total body fat mass to weight-bearing bone volumetric density, geometry, and strength in young girls. Bone 2010, 46:977-984.
40. McDonald C.M., Abresch-Meyer A.L., Nelson M.D., Widman L.M. Body Mass Index and Body Composition Measures by Dual X-Ray Absorptiometry in Patients Aged 10 to 21 Years With Spinal Cord Injury. J Spinal Cord Med 2007, 30:S97-S104.
41. Arabi A., Tamim H., Nabulsi M., Maalouf J., Khalifé H., Choucair M., et al. Sex differences in the effect of body-composition variables on bone mass in healthy children and adolescents. Am J Clin Nutr 2004, 80:1428-1435.
42. Faulkner R.A., Bailey D.A., Drinkwater D.T., Wilkinson A.A., Houston C.S., McKay H.A. Regional and total body bone mineral content, bone mineral density, and total body tissue composition in children 8-16 years of age. Calcif Tissue Int 1993, 53:7-12.
43. Goulding A., Taylor R.W., Grant A.M., Murdoch L., Williams S.M., Taylor B.J. Relationship of total body fat mass to bone area in New Zealand five-year-olds. Calcif Tissue Int 2008, 82:293-299.
44. Clark E.M., Ness A.R., Tobias J.H. Adipose tissue stimulates bone growth in prepubertal children. J Clin Endocrinol Metab 2006, 91:2534-2541.
45. Pollock N.K., Laing E.M., Baile C.A., Hamrick M.W., Hall D.B., Lewis R.D. Is adiposity advantageous for bone strength? A peripheral quantitative computed tomography study in late adolescent females. Am J Clin Nutr 2007, 86:1530-1538.
46. Baroncelli G.I. Quantitative ultrasound methods to assess bone mineral status in children: technical characteristics, performance, and clinical application. Pediatr Res 2008, 63:220-228.