Primary aldosteronism: cardiovascular, renal and metabolic implications

Trends in Endocrinology and Metabolism

Volumn 19, Issue 3, 2008, Pages 88-90

  Rossi, Gian Paolo ^a   Sechi, Leonardo A ^b   Giacchetti, Gilberta ^c   Ronconi, Vanessa ^c   Strazzullo, Pasquale ^d   Funder, John W ^e  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPLERENONE; MINERALOCORTICOID RECEPTOR; SPIRONOLACTONE;

BLOOD PRESSURE; CLINICAL FEATURE; DIABETIC HYPERTENSION; DRUG MECHANISM; ELECTROCARDIOGRAM; GLOMERULUS FILTRATION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; HYPERTENSION; KIDNEY INJURY; LOW DRUG DOSE; METABOLIC REGULATION; NONHUMAN; PRIMARY HYPERALDOSTERONISM; PRIORITY JOURNAL; REVIEW; VASODILATATION;

CARDIOVASCULAR SYSTEM; HUMANS; HYPERALDOSTERONISM; HYPERTENSION; KIDNEY; METABOLIC SYNDROME X; RISK FACTORS;

EID: 41149087926     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2008.01.006     Document Type: Review

References (37)

1. Milliez P., et al. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J. Am. Coll. Cardiol. 45 (2005) 1243-1248
2. Rossi G.P., et al. Left ventricular systolic function in primary aldosteronism and hypertension. J. Hypertens. 19 (1997) S147-S151
3. Rossi G.P., et al. Remodeling of the left ventricle in primary aldosteronism due to Conn's adenoma. Circulation 95 (1997) 1471-1478
4. Rossi G.P., et al. Imaging of aldosterone-secreting adenomas: a prospective comparison of computed tomography and magnetic resonance imaging in 27 patients with suspected primary aldosteronism. J. Hum. Hypertens. 7 (1993) 357-363
5. Rizzoni D., et al. Endothelial dysfunction in hypertension is independent from the etiology and from vascular structure. Hypertension 31 (1998) 335-341
6. Rizzoni D., et al. Relations between cardiac and vascular structure in patients with primary and secondary hypertension. J. Am. Coll. Cardiol. 32 (1998) 985-992
7. Campbell S.E., et al. Fibrosis of the human heart and systemic organs in adrenal adenoma. Blood Press. 1 (1992) 149-156
8. Rossi G.P., et al. Excess aldosterone is associated with alterations of myocardial texture in primary aldosteronism. Hypertension 40 (2002) 23-27
9. Kozakova M., et al. Myocardial ultrasonic backscatter in hypertension: relation to aldosterone and endothelin. Hypertension 41 (2003) 230-236
10. Muiesan M.L., et al. Structural changes in small resistance arteries and left ventricular geometry in patients with primary and secondary hypertension. J. Hypertens. 20 (2002) 1439-1444
11. Rocha R., and Stier C. Pathophysiological effects of aldosterone in cardiovascular tissue. Trends Endocrinol. Metab. 12 (2001) 308-314
12. Rocha R., et al. Selective aldosterone blockade prevents angiotensin II/salt induced vascular inflammation in the rat heart. Endocrinology 143 (2002) 4828-4836
13. Stowasser M., et al. Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism Type I. J. Clin. Endocrinol. Metab. 90 (2005) 5070-5076
14. Dworkin L.D., et al. Hemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension. J. Clin. Invest. 73 (1984) 1448-1461
15. Uhrenholt T.R., et al. Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone. Circ. Res. 93 (2003) 1258-1266
16. Kimura G., et al. Renal function curve in patients with secondary forms of hypertension. Hypertension 10 (1987) 11-16
17. Hollenberg N.K. Aldosterone in the development and progression of renal injury. Kidney Int. 66 (2004) 1-9
18. Lam E.Y., et al. Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in DOC/salt rats. Endocrinology 147 (2006) 3623-3629
19. Epstein M., et al. Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type-2 diabetes. Clin. J. Am. Soc. Nephrol. 1 (2006) 940-951
20. Nishimura M., et al. Cardiovascular complications in patients with primary aldosteronism. Am. J. Kidney Dis. 33 (1999) 261-266
21. Rossi G.P., et al. Renal damage in primary aldosteronism. Results of the PAPY study. Hypertension 48 (2006) 232-238
22. Catena C., et al. Relationships of plasma renin levels with renal function in patients with primary aldosteronism. Clin. J. Am. Soc. Nephrol. 2 (2007) 722-731
23. Sechi L.A., et al. Long-term renal outcomes in patients with primary aldosteronism. JAMA. 295 (2006) 2638-2645
24. Ribstein J., et al. Relative glomerular hyperfiltration in primary aldosteronism. J. Am. Soc. Nephrol. 16 (2005) 1320-1325
25. Nagase, M. et al. Salt-induced nephropathy in obese SHR via paradoxical activation of mineralocorticoid receptor: role of oxidative stress. Hypertension (in press)
26. Conn J.W., et al. Clinical characteristics of primary aldosteronism from an analysis of 145 cases. Am. J. Surg. 107 (1964) 159-172
27. Carranza M.C., et al. Decreased insulin receptor number and affinity in subcutaneous adipose tissue in a patient with primary hyperaldosteronism. Rev. Clin. Esp. 188 (1991) 414-417
28. Shimamoto K., et al. Does insulin resistance participate in an impaired glucose tolerance in primary aldosteronism. J. Hum. Hypertens. 8 (1994) 755-759
29. Sindelka G., et al. Insulin action in primary aldosteronism before and after surgical or pharmacological treatment. Exp. Clin. Endocrinol. Diabetes 108 (2000) 21-30
30. Widimsky J., et al. Impaired insulin action in primary aldosteronism. Physiol. Res. 49 (2000) 241-244
31. Catena C., et al. Insulin sensitivity in patients with primary aldosteronism: a follow-up study. J. Clin. Endocrinol. Metab. 91 (2006) 3457-3463
32. Fallo F., et al. Prevalence and characteristics of the metabolic syndrome in primary aldosteronism. J. Clin. Endocrinol. Metab. 91 (2006) 454-459
33. Giacchetti G., et al. Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study. J. Hypertens. 25 (2007) 177-186
34. Skrha J., et al. Comparison of the insulin action parameters from hyperinsulinemic clamps with homeostasis model assessment and QUICK1 indexes in subjects with different endocrine disorders. J. Clin. Endocrinol. Metab. 89 (2004) 135-141
35. Widimsky J., et al. Can primary hyperaldosteronism be considered as a specific form of diabetes mellitus?. Physiol. Res. 50 (2001) 603-607
36. Smiley D., et al. Primary aldosteronism in diabetic subjects with resistant hypertension. Diabetes Care 30 (2007) 1699-1703
37. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2000) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 23, S4-S19