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Volumn 114-115, Issue , 2012, Pages 39-48

Effects of a toxic cyanobacterial bloom (Planktothrix agardhii) on fish: Insights from histopathological and quantitative proteomic assessments following the oral exposure of medaka fish (Oryzias latipes)

Author keywords

Cyanotoxins; Liver; Medaka fish; Microcystins; Vitellogenin

Indexed keywords

GLYCOGEN; MICROCYSTIN LR;

EID: 84857987778     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2012.02.008     Document Type: Article
Times cited : (57)

References (49)
  • 1
    • 73249127370 scopus 로고    scopus 로고
    • Oxidative stress generation by microcystins in aquatic animals: why and how
    • Amado L.L., Monserrat J.M. Oxidative stress generation by microcystins in aquatic animals: why and how. Environ. Int. 2010, 36:226-235.
    • (2010) Environ. Int. , vol.36 , pp. 226-235
    • Amado, L.L.1    Monserrat, J.M.2
  • 2
    • 58149503746 scopus 로고    scopus 로고
    • Effect of diatery selenium on the oxidative stress and pathological change in tilapia (Oreochromis nilocitus) exposed to a microcystin-producing cyanobacterial water bloom
    • Atencio L., Morno I., Jos A., Prieto A.I., Moyano R., Blanco A., Caméan A.M. Effect of diatery selenium on the oxidative stress and pathological change in tilapia (Oreochromis nilocitus) exposed to a microcystin-producing cyanobacterial water bloom. Toxicon 2009, 53:269-282.
    • (2009) Toxicon , vol.53 , pp. 269-282
    • Atencio, L.1    Morno, I.2    Jos, A.3    Prieto, A.I.4    Moyano, R.5    Blanco, A.6    Caméan, A.M.7
  • 3
    • 38349124797 scopus 로고    scopus 로고
    • Isolation and endotoxin activity of polysaccharides from cyanobacterial cultures and complex water blooms and comparison with the effects of heterotrophic bacteria and green algae
    • Bernardova K., Babica P., Marsalek B., Blaha L. Isolation and endotoxin activity of polysaccharides from cyanobacterial cultures and complex water blooms and comparison with the effects of heterotrophic bacteria and green algae. J. Appl. Toxicol. 2008, 28:72-77.
    • (2008) J. Appl. Toxicol. , vol.28 , pp. 72-77
    • Bernardova, K.1    Babica, P.2    Marsalek, B.3    Blaha, L.4
  • 4
    • 0037700501 scopus 로고    scopus 로고
    • Effects of microcystis cells and polysaccharides on drinking and liver function in rainbow trout Oncorhynchus mykiss Walbaum
    • Best J.H., Eddy F.B., Codd G.A. Effects of microcystis cells and polysaccharides on drinking and liver function in rainbow trout Oncorhynchus mykiss Walbaum. Aquat. Toxicol. 2003, 64:419-426.
    • (2003) Aquat. Toxicol. , vol.64 , pp. 419-426
    • Best, J.H.1    Eddy, F.B.2    Codd, G.A.3
  • 7
    • 33244491934 scopus 로고    scopus 로고
    • Attenuating effects of natural organic matter on microcystin toxicity in zebrafish (Danio rerio) embryos-benefits and costs of microcystin detoxification
    • Cazenave J., de los Angeles Bistoni M., Zwirnmann E., Wunderlin D., Wiegand C. Attenuating effects of natural organic matter on microcystin toxicity in zebrafish (Danio rerio) embryos-benefits and costs of microcystin detoxification. Environ. Toxicol. 2005, 21:22-32.
    • (2005) Environ. Toxicol. , vol.21 , pp. 22-32
    • Cazenave, J.1    de los Angeles Bistoni, M.2    Zwirnmann, E.3    Wunderlin, D.4    Wiegand, C.5
  • 9
    • 77956312086 scopus 로고    scopus 로고
    • Structure, function, and mechanism of thioredoxin proteins
    • Collet J.-F., Messens J. Structure, function, and mechanism of thioredoxin proteins. Antioxid. Redox Signal. 2010, 13:1205-1215.
    • (2010) Antioxid. Redox Signal. , vol.13 , pp. 1205-1215
    • Collet, J.-F.1    Messens, J.2
  • 10
    • 84934436178 scopus 로고    scopus 로고
    • Toxin mixture in cyanobacterial blooms - a critical comparison of reality with current procedures employed in human health risk assessment
    • Dietrich D.R., Fisher A., Michel C., Hoeger S.J. Toxin mixture in cyanobacterial blooms - a critical comparison of reality with current procedures employed in human health risk assessment. Adv. Exp. Med. Biol. 2008, 619:885-912.
    • (2008) Adv. Exp. Med. Biol. , vol.619 , pp. 885-912
    • Dietrich, D.R.1    Fisher, A.2    Michel, C.3    Hoeger, S.J.4
  • 11
    • 72749099949 scopus 로고    scopus 로고
    • Localization of microcystin-LR in medaka fish tissues after cyanotoxin gavaged
    • Djediat C., Malécot M., de Luze A., Bernard C., Puiseux Dao S., Edery M. Localization of microcystin-LR in medaka fish tissues after cyanotoxin gavaged. Toxicon 2010, 55:531-535.
    • (2010) Toxicon , vol.55 , pp. 531-535
    • Djediat, C.1    Malécot, M.2    de Luze, A.3    Bernard, C.4    Puiseux Dao, S.5    Edery, M.6
  • 12
    • 79959378733 scopus 로고    scopus 로고
    • Oral toxicity of extracts of microcystin-containing cyanobacterium Planktothrix agardhii to medaka fish (Oryzias latipes)
    • Djediat C., Moyenga D., Malécot M., Comte K., Yéprémiam C., Bernard C., Puiseux-Dao S., Edery M. Oral toxicity of extracts of microcystin-containing cyanobacterium Planktothrix agardhii to medaka fish (Oryzias latipes). Toxicon 2011, 58:112-122.
    • (2011) Toxicon , vol.58 , pp. 112-122
    • Djediat, C.1    Moyenga, D.2    Malécot, M.3    Comte, K.4    Yéprémiam, C.5    Bernard, C.6    Puiseux-Dao, S.7    Edery, M.8
  • 13
    • 0035204961 scopus 로고    scopus 로고
    • Presence of Planktothrix sp. and cyanobacterial toxins in lake Ammersee, Germany and their impact on whitefish (Coregonus lavaretus L.)
    • Ernst B., Hitzfeld B., Dietrich D.R. Presence of Planktothrix sp. and cyanobacterial toxins in lake Ammersee, Germany and their impact on whitefish (Coregonus lavaretus L.). Environ. Toxicol. 2001, 16:483-488.
    • (2001) Environ. Toxicol. , vol.16 , pp. 483-488
    • Ernst, B.1    Hitzfeld, B.2    Dietrich, D.R.3
  • 14
    • 33745991801 scopus 로고    scopus 로고
    • Oral toxicity of microcystin-containing cyanobacterium Planktothrix rubescens in European whitefish (Coregonus lavaretus)
    • Ernst B., Hoeger S.J., O'Brien E., Dietrich D.R. Oral toxicity of microcystin-containing cyanobacterium Planktothrix rubescens in European whitefish (Coregonus lavaretus). Aquat. Toxicol. 2006, 79:31-40.
    • (2006) Aquat. Toxicol. , vol.79 , pp. 31-40
    • Ernst, B.1    Hoeger, S.J.2    O'Brien, E.3    Dietrich, D.R.4
  • 15
    • 0034106372 scopus 로고    scopus 로고
    • Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical localization in the livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss)
    • Fisher W.J., Hitzfeld B.C., Tencalla F., Reiksson J.E., Mikhailov A., Dietrich D.R. Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical localization in the livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss). Toxicol. Sci. 2000, 54:365-373.
    • (2000) Toxicol. Sci. , vol.54 , pp. 365-373
    • Fisher, W.J.1    Hitzfeld, B.C.2    Tencalla, F.3    Reiksson, J.E.4    Mikhailov, A.5    Dietrich, D.R.6
  • 16
    • 0034176293 scopus 로고    scopus 로고
    • Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio)
    • Fisher W.J., Dietrich D.R. Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio). Toxicol. Appl. Pharmacol. 2000, 164:73-981.
    • (2000) Toxicol. Appl. Pharmacol. , vol.164 , pp. 73-981
    • Fisher, W.J.1    Dietrich, D.R.2
  • 19
    • 18244404213 scopus 로고    scopus 로고
    • Effect of estrogenic activity, and phytoestrogen and organochlorine pesticide contents in an experimental fish diet on reproduction and hepatic vitellogenin production in medaka (Oryzias latipes)
    • Inudo M., Ishibashi H., Matsumura N., Mori T., Taniyama S., Kadokami K., Koga M., Shinohara R., Hutchinson T.H., Igushi T., Arizono K. Effect of estrogenic activity, and phytoestrogen and organochlorine pesticide contents in an experimental fish diet on reproduction and hepatic vitellogenin production in medaka (Oryzias latipes). Comp. Med. 2004, 54:673-680.
    • (2004) Comp. Med. , vol.54 , pp. 673-680
    • Inudo, M.1    Ishibashi, H.2    Matsumura, N.3    Mori, T.4    Taniyama, S.5    Kadokami, K.6    Koga, M.7    Shinohara, R.8    Hutchinson, T.H.9    Igushi, T.10    Arizono, K.11
  • 21
    • 16844374445 scopus 로고    scopus 로고
    • Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions
    • Jos A., Pichardo S., Prieto A.I., Repetto G., Vazquez C.M., Moreno I., Camean A.M. Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions. Aquat. Toxicol. 2005, 72:261-271.
    • (2005) Aquat. Toxicol. , vol.72 , pp. 261-271
    • Jos, A.1    Pichardo, S.2    Prieto, A.I.3    Repetto, G.4    Vazquez, C.M.5    Moreno, I.6    Camean, A.M.7
  • 22
    • 0033168956 scopus 로고    scopus 로고
    • Vitellogenesis as a biomarker of reproductive disruption by xenobiotics
    • Kime D.E., Nash J.P., Scott A.P. Vitellogenesis as a biomarker of reproductive disruption by xenobiotics. Aquaculture 1999, 177:345-352.
    • (1999) Aquaculture , vol.177 , pp. 345-352
    • Kime, D.E.1    Nash, J.P.2    Scott, A.P.3
  • 23
    • 78649478304 scopus 로고    scopus 로고
    • Hyphenated technique for the extraction and the determination of isoflavones in algae: ultrasound-assisted supercritical fluid extraction followed by fast chromatography with tandem mass spectrometry
    • Kledjus B., Lojkova L., Plaza M., Snoblova M., Sterbova D. Hyphenated technique for the extraction and the determination of isoflavones in algae: ultrasound-assisted supercritical fluid extraction followed by fast chromatography with tandem mass spectrometry. J. Chromatogr. A 2010, 1217:7956-7965.
    • (2010) J. Chromatogr. A , vol.1217 , pp. 7956-7965
    • Kledjus, B.1    Lojkova, L.2    Plaza, M.3    Snoblova, M.4    Sterbova, D.5
  • 24
    • 0037210790 scopus 로고    scopus 로고
    • Binding affinity of hepatic nuclear estrogen receptors for phytoestrogens in rainbow trout (Oncorhynchus mykiss) and Siberian sturgeon (Acipenser baeri)
    • Latonnelle K., Fostier A., Le Menn F., Bennetau-Pelissero C. Binding affinity of hepatic nuclear estrogen receptors for phytoestrogens in rainbow trout (Oncorhynchus mykiss) and Siberian sturgeon (Acipenser baeri). Gen. Comp. Endocrinol. 2002, 129:69-79.
    • (2002) Gen. Comp. Endocrinol. , vol.129 , pp. 69-79
    • Latonnelle, K.1    Fostier, A.2    Le Menn, F.3    Bennetau-Pelissero, C.4
  • 25
    • 38149000922 scopus 로고    scopus 로고
    • Effects of cyanobacterial crude extracts from Planktothrix agardhii on embryo-larval development of the medaka fish, Oryzias latipes
    • Lecoz N., Malécot M., Quiblier C., Puiseux-Dao S., Bernard C., Crespeau F., Edery M. Effects of cyanobacterial crude extracts from Planktothrix agardhii on embryo-larval development of the medaka fish, Oryzias latipes. Toxicon 2008, 51:262-269.
    • (2008) Toxicon , vol.51 , pp. 262-269
    • Lecoz, N.1    Malécot, M.2    Quiblier, C.3    Puiseux-Dao, S.4    Bernard, C.5    Crespeau, F.6    Edery, M.7
  • 26
    • 79955770951 scopus 로고    scopus 로고
    • Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR
    • Li G., Chen J., Jiang Y., Wu L., Zhang X. Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR. Proteomics 2011, 11:2003-2018.
    • (2011) Proteomics , vol.11 , pp. 2003-2018
    • Li, G.1    Chen, J.2    Jiang, Y.3    Wu, L.4    Zhang, X.5
  • 27
    • 34547144685 scopus 로고    scopus 로고
    • Sequential ultrastructural and biochemical changes induced in vivo by the hepatotoxic microcystins in liver of the phytoplanktivorous silver carp Hypophthalmichthys molitrix
    • Li L., Xie P., LI X., Giu T., Guo L. Sequential ultrastructural and biochemical changes induced in vivo by the hepatotoxic microcystins in liver of the phytoplanktivorous silver carp Hypophthalmichthys molitrix. Comp. Biochem. Physiol. C 2007, 146:357-367.
    • (2007) Comp. Biochem. Physiol. C , vol.146 , pp. 357-367
    • Li, L.1    Xie, P.2    Li, X.3    Giu, T.4    Guo, L.5
  • 29
    • 68249107159 scopus 로고    scopus 로고
    • Proteomic study of the effects of microcystin-LR on organelle and membrane proteins in medaka fish liver
    • Malécot M., Mezhoud K., Marie A., Praseulth D., Puiseux-Dao S., Edery M. Proteomic study of the effects of microcystin-LR on organelle and membrane proteins in medaka fish liver. Aquat. Toxicol. 2009, 94:153-161.
    • (2009) Aquat. Toxicol. , vol.94 , pp. 153-161
    • Malécot, M.1    Mezhoud, K.2    Marie, A.3    Praseulth, D.4    Puiseux-Dao, S.5    Edery, M.6
  • 30
    • 79955840237 scopus 로고    scopus 로고
    • ITRAQ-based proteomic study of the effects of microcystin-LR on medaka fish liver
    • Malécot M., Marie A., Puiseux-Dao S., Edery M. iTRAQ-based proteomic study of the effects of microcystin-LR on medaka fish liver. Proteomics 2011, 11:2071-2078.
    • (2011) Proteomics , vol.11 , pp. 2071-2078
    • Malécot, M.1    Marie, A.2    Puiseux-Dao, S.3    Edery, M.4
  • 32
    • 38749111845 scopus 로고    scopus 로고
    • Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR: I. Balneation study
    • Mezhoud K., Praseuth D., Puiseux-Dao S., François J., Bernard C., Edery M. Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR: I. Balneation study. Aquat. Toxicol. 2008, 86:166-175.
    • (2008) Aquat. Toxicol. , vol.86 , pp. 166-175
    • Mezhoud, K.1    Praseuth, D.2    Puiseux-Dao, S.3    François, J.4    Bernard, C.5    Edery, M.6
  • 33
    • 79956358637 scopus 로고    scopus 로고
    • Toxins and stress in fish: proteomic analysis and response network
    • Mezhoud K., Puiseux-Dao S., Edery M. Toxins and stress in fish: proteomic analysis and response network. Toxicon 2011, 57:959-969.
    • (2011) Toxicon , vol.57 , pp. 959-969
    • Mezhoud, K.1    Puiseux-Dao, S.2    Edery, M.3
  • 34
    • 0031281308 scopus 로고    scopus 로고
    • Effects of microcystin-LR and cyanobacterial crude extracts on embryo-larval development of zebrafish (Danio rerio)
    • Oberemm A., Fastner J., Steinberg C.E.W. Effects of microcystin-LR and cyanobacterial crude extracts on embryo-larval development of zebrafish (Danio rerio). Water Res. 1997, 31:2918-2921.
    • (1997) Water Res. , vol.31 , pp. 2918-2921
    • Oberemm, A.1    Fastner, J.2    Steinberg, C.E.W.3
  • 35
    • 33847072698 scopus 로고    scopus 로고
    • Effect of different cyanobacterial biomasses and their fractions with variable microcystin content on embryonal development of carp (Cyprinus carpio L.)
    • Palikova M., Krejci R., Hilscherova K., Babica P., Navratil S., Kopp R., Blaha L. Effect of different cyanobacterial biomasses and their fractions with variable microcystin content on embryonal development of carp (Cyprinus carpio L.). Aquat. Toxicol. 2007, 81:312-318.
    • (2007) Aquat. Toxicol. , vol.81 , pp. 312-318
    • Palikova, M.1    Krejci, R.2    Hilscherova, K.3    Babica, P.4    Navratil, S.5    Kopp, R.6    Blaha, L.7
  • 36
    • 0020996188 scopus 로고
    • Lipopolysaccharides of the cyanobacterium Microcystis aeruginosa
    • Raziuddin S., Siegelman H.W., Tornabene T.G. Lipopolysaccharides of the cyanobacterium Microcystis aeruginosa. Eur. J. Biochem. 1983, 137:333-336.
    • (1983) Eur. J. Biochem. , vol.137 , pp. 333-336
    • Raziuddin, S.1    Siegelman, H.W.2    Tornabene, T.G.3
  • 37
    • 79952180931 scopus 로고    scopus 로고
    • Global gene expression profiling in larval zebrafish exposed to microcystin-LR and microcystis reveals endocrine disrupting effects of cyanobacteria
    • Rogers E.D., Henry T.J., Twiner M.J., Gouffon J.S., McPherson J.T., Boyer G.L., Sayler G.S., Wilhelm S.W. Global gene expression profiling in larval zebrafish exposed to microcystin-LR and microcystis reveals endocrine disrupting effects of cyanobacteria. Environ. Sci. Technol. 2011, 45:1962-1969.
    • (2011) Environ. Sci. Technol. , vol.45 , pp. 1962-1969
    • Rogers, E.D.1    Henry, T.J.2    Twiner, M.J.3    Gouffon, J.S.4    McPherson, J.T.5    Boyer, G.L.6    Sayler, G.S.7    Wilhelm, S.W.8
  • 39
    • 73049083343 scopus 로고    scopus 로고
    • Alteration and recovery of antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: its relation to liver lipid composition
    • Sedan D., Andinolo D., Telese L., Giannuzzi L., de Alaniz M.J.T., Marra C.A. Alteration and recovery of antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: its relation to liver lipid composition. Toxicon 2010, 55:333-342.
    • (2010) Toxicon , vol.55 , pp. 333-342
    • Sedan, D.1    Andinolo, D.2    Telese, L.3    Giannuzzi, L.4    de Alaniz, M.J.T.5    Marra, C.A.6
  • 40
    • 80052534243 scopus 로고    scopus 로고
    • In vitro modulation of intracellular receptor signalling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions
    • Stepankova T., Ambrozova L., Blaha L., Giesy J.P., Hilscherova K. In vitro modulation of intracellular receptor signalling and cytotoxicity induced by extracts of cyanobacteria, complex water blooms and their fractions. Aquat. Toxicol. 2011, 105:497-507.
    • (2011) Aquat. Toxicol. , vol.105 , pp. 497-507
    • Stepankova, T.1    Ambrozova, L.2    Blaha, L.3    Giesy, J.P.4    Hilscherova, K.5
  • 41
    • 0028840615 scopus 로고
    • Vitellogenesis as a biomarker of estrogenic contamination of the aquatic environment
    • Sumpter J., Jobling S. Vitellogenesis as a biomarker of estrogenic contamination of the aquatic environment. Environ. Health Perspect. 1995, 103:173-178.
    • (1995) Environ. Health Perspect. , vol.103 , pp. 173-178
    • Sumpter, J.1    Jobling, S.2
  • 42
    • 80755140073 scopus 로고    scopus 로고
    • Pathological modifications following sub-chronic exposure of medaka fish (Oryzias latipes) to microcystin-LR
    • Trinchet I., Djediat C., Huet H., Puiseux-Dao S., Edery M. Pathological modifications following sub-chronic exposure of medaka fish (Oryzias latipes) to microcystin-LR. Reprod. Toxicol. 2011, 32:329-340.
    • (2011) Reprod. Toxicol. , vol.32 , pp. 329-340
    • Trinchet, I.1    Djediat, C.2    Huet, H.3    Puiseux-Dao, S.4    Edery, M.5
  • 43
    • 75249106631 scopus 로고    scopus 로고
    • Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR
    • Wang M., Chan L.L., Si M., Hong H., Wang D. Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR. Toxicol. Sci. 2010, 113:60-69.
    • (2010) Toxicol. Sci. , vol.113 , pp. 60-69
    • Wang, M.1    Chan, L.L.2    Si, M.3    Hong, H.4    Wang, D.5
  • 44
    • 0034834317 scopus 로고    scopus 로고
    • Dietary of soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats
    • Weber K.S., Setchell K.D., Stocco D.M., Lephart E.D. Dietary of soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats. J. Endocrinol. 2001, 170:591-599.
    • (2001) J. Endocrinol. , vol.170 , pp. 591-599
    • Weber, K.S.1    Setchell, K.D.2    Stocco, D.M.3    Lephart, E.D.4
  • 47
    • 84856251793 scopus 로고    scopus 로고
    • The role of cysteine conjugation in the detoxification of microcystin-LR in the liver of the bighead carp (Aristichtys nobilis): a field and laboratory study
    • Zhang D., Yang Q., Xie P., Deng X., Chen J., Dai M. The role of cysteine conjugation in the detoxification of microcystin-LR in the liver of the bighead carp (Aristichtys nobilis): a field and laboratory study. Ecotoxicology 2012, 21:244-252.
    • (2012) Ecotoxicology , vol.21 , pp. 244-252
    • Zhang, D.1    Yang, Q.2    Xie, P.3    Deng, X.4    Chen, J.5    Dai, M.6
  • 48
    • 27844545199 scopus 로고    scopus 로고
    • Molecular cloning and expression pattern of 14kDa apolipoprotein in orange-spotted grouper, Epinephelus coioides
    • Zhou L., Wang Y., Yao B., Li C-J., Ji G-D. Molecular cloning and expression pattern of 14kDa apolipoprotein in orange-spotted grouper, Epinephelus coioides. Comp. Biochem. Physiol. B 2005, 142:432-437.
    • (2005) Comp. Biochem. Physiol. B , vol.142 , pp. 432-437
    • Zhou, L.1    Wang, Y.2    Yao, B.3    Li, C.-J.4    Ji, G.-D.5
  • 49
    • 11244346943 scopus 로고    scopus 로고
    • Hepatotoxic cyanobacteria: a review of the biological importance of microcystins in freshwater environments
    • Zurawell R., Chen H., Burke J.M., Prepas E.E. Hepatotoxic cyanobacteria: a review of the biological importance of microcystins in freshwater environments. J. Toxicol. Environ. Health B Crit. Rev. 2005, 8:1-37.
    • (2005) J. Toxicol. Environ. Health B Crit. Rev. , vol.8 , pp. 1-37
    • Zurawell, R.1    Chen, H.2    Burke, J.M.3    Prepas, E.E.4


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