Polyethyleneimine-Based Core-Shell Nanogels: A Promising siRNA Carrier for Argininosuccinate Synthetase mRNA Knockdown in HeLa Cells

Journal of Controlled Release

Volumn 158, Issue 1, 2012, Pages 123-130

  Mimi, Hetti ^a   Ho, Kin Man ^a   Siu, Yuen Shan ^a   Wu, Aihua ^a   Li, Pei ^a  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Argininosuccinate Synthetase; Core shell nanogel; Gelatin; Polyethyleneimine; siRNA delivery

Indexed keywords

CORE-SHELL; GELATIN; POLYETHYLENEIMINE; SIRNA DELIVERY; SYNTHETASES;

CYTOLOGY; GENE EXPRESSION; GENETIC ENGINEERING; LIPOSOMES; NANOPARTICLES; NANOSTRUCTURED MATERIALS; RNA; SHELLS (STRUCTURES); SYNTHESIS (CHEMICAL);

POLYETHYLENES;

AMPHOPHILE; ARGININOSUCCINATE SYNTHASE; GELATIN; MESSENGER RNA; NANOCARRIER; NANOGEL; NANOSHELL; POLYETHYLENEIMINE; RIBONUCLEASE A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENZYMATIC DEGRADATION; FLOW CYTOMETRY; GELATINIZATION; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR STABILITY; PH; PRIORITY JOURNAL; RNA INTERFERENCE; RNA TRANSPORT; SOLUBILITY; ZETA POTENTIAL;

ARGININOSUCCINATE SYNTHASE; CELL SURVIVAL; GELATIN; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84857917025     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.10.035     Document Type: Article

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33. S.-Y. Lee, M.S. Huh, S. Lee, S.J. Lee, H. Chung, J.H. Park, Y.-K. Oh, K. Choi, K. Kim, and I.C. Kwon Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing J. Control. Release 141 2010 339 346
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37. T. Merdan, K. Kunath, D. Fischer, J. Kopecek, and T. Kissel Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments Pharm. Res. 19 2002 140 146 (Pubitemid 34165398)
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44. F. Izzo, P. Marra, G. Beneduce, G. Castello, P. Vallone, V. De Rosa, F. Cremona, C.M. Ensor, F.W. Holtsberg, J.S. Bomalaski, M.A. Clark, C. Ng, and S.A. Curley Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies J. Clin. Oncol. 22 2004 1815 1822 (Pubitemid 41095171)
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50. M.F. Leung, and P. Li Smart Microgel Particles with Tuneable Responses: Synthesis, Properties and Application of Well-Defined Core-Shell Microgels 2009 VDM-Verlag Germany
51. P.B. Kajjari, L.S. Manjeshwar, and T.M. Aminabhavi Semi-interpenetrating polymer network hydrogel blend microspheres of gelatin and hydroxyethyl cellulose for controlled release of theophylline Ind. Eng. Chem. Res. 50 2011 7833 7840
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53. R. Manivannan Nano technology: a review J. Appl. Pharm. Sci. 1 2011 8 16
54. S. Galindo-Rodriguez, E. Allémann, H. Fessi, and E. Doelker Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods Pharm. Res. 21 2004 1428 1439 (Pubitemid 39149658)