Endothelial and axon reflex vasodilatation to acetylcholine in rosacea-affected skin

Archives of Dermatological Research

Volumn 304, Issue 2, 2012, Pages 133-137

  Drummond, Peter D ^a   Su, Daphne ^a  

^a MURDOCH UNIVERSITY   (Australia)

Author keywords

Acetylcholine iontophoresis; Axon reflex; Endothelial vasodilatation; Neurogenic inflammation; Rosacea; Skin blood flow

Indexed keywords

ACETYLCHOLINE;

ADULT; AGED; ARTICLE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTHELIUM; FEMALE; FLUSHING; FOREHEAD; HUMAN; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; MALE; NERVE FIBER; PRIORITY JOURNAL; REFLEX; ROSACEA; SKIN BLOOD FLOW; SKIN SENSATION; SKIN SENSITIVITY; STINGING SENSATION; VASODILATATION;

ACETYLCHOLINE; ADULT; AXONS; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; FEMALE; HEMODYNAMICS; HUMANS; IONTOPHORESIS; LASER-DOPPLER FLOWMETRY; MALE; MIDDLE AGED; NERVE FIBERS; NOCICEPTORS; REFLEX; ROSACEA; SKIN; VASODILATION;

EID: 84857900807     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-011-1177-1     Document Type: Article

References (28)

1. Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R (2002) Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation. J Appl Physiol 92:780-788 (Pubitemid 34671048)
2. Borrie P (1955) The state of the blood vessels of the face in rosacea. I. Br J Dermatol 67:5-8
3. Borrie P (1955) The state of the blood vessels of the face in rosacea. II. Br J Dermatol 67:73-75
4. Braverman IM, Keh A, Goldminz D (1990) Correlation of laser Doppler wave patterns with underlying microvascular anatomy. J Invest Dermatol 95:283-286 (Pubitemid 20261857)
5. Culp B, Scheinfeld N (2009) Rosacea: a review. P & T 34:38-45
6. Curry FR, Adamson RH (2010) Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge. Cardiovasc Res 87:218-229
7. Drummond PD (2002) Prior iontophoresis of saline enhances vasoconstriction to phenylephrine and clonidine in the skin of the human forearm. Br J Clin Pharmacol 54:45-50
8. Elewski BE, Draelos Z, Dreno B, Jansen T, Layton A, Picardo M (2011) Rosacea - global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol 25:188-200
9. Grossmann M, Jamieson MJ, Kellogg DL Jr, Kosiba WA, Pergola PE, Crandall CG, Shepherd AM (1995) The effect of iontophoresis on the cutaneous vasculature: evidence for current-induced hyperemia. Microvasc Res 50:444-452
10. Guarrera M, Parodi A, Cipriani C, Divano C, Rebora A (1982) Flushing in rosacea: a possible mechanism. Arch Dermatol Res 272:311-316 (Pubitemid 12113031)
11. Hodges GJ, Johnson JM (2009) Adrenergic control of the human cutaneous circulation. Appl Physiol Nutr Metab 34:829-839
12. Holowatz LA, Thompson-Torgerson C, Kenney WL (2010) Aging and the control of human skin blood Xow. Front Biosci 15:718-739
13. Kurkcuoglu N, Alaybeyi F (1991) Substance P immunoreactivity in rosacea. J Am Acad Dermatol 25:725-726
14. Lindsey KQ, Caughman SW, Olerud JE, Bunnett NW, Armstrong CA, Ansel JC (2000) Neural regulation of endothelial cell-mediated inXammation. J Investig Dermatol Symp Proc 5:74-78 (Pubitemid 32044093)
15. Lonne-Rahm S, Nordlind K, Edstrom DW, Ros AM, Berg M (2004) Laser treatment of rosacea: a pathoetiological study. Arch Dermatol 140:1345-1349 (Pubitemid 39473634)
16. Marks R, Harcourt-Webster JN (1969) Histopathology of rosacea. Arch Dermatol 100:683-691
17. Peters EM, Ericson ME, Hosoi J, Seiffert K, Hordinsky MK, Ansel JC, Paus R, Scholzen TE (2006) Neuropeptide control mechanisms in cutaneous biology: physiological and clinical significance. J Invest Dermatol 126:1937-1947
18. Powell FC, Corbally N, Powell D (1993) Substance P and rosacea. J Am Acad Dermatol 28:132-133
19. Schmelz M, Michael K, Weidner C, Schmidt R, Torebjork HE, Handwerker HO (2000) Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport 11:645-648 (Pubitemid 30120491)
20. Su D, Drummond PD (2011) Blushing propensity and psychological distress in people with rosacea. Clin Psychol Psychother. doi:10.1002/cpp.763
21. van den Oever IA, Raterman HG, Nurmohamed MT, Simsek S (2010) Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Mediat Inflamm 2010:792393
22. Webster GF (2009) Rosacea. Med Clin North Am 93:1183-1194
23. Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, Petersen LJ, Schmelz M (2000) Acute effects of substance P and calcitonin gene-related peptide in human skin-a microdialysis study. J Invest Dermatol 115:1015-1020 (Pubitemid 32037445)
24. Wilkin J, Dahl M, Detmar M, Drake L, Feinstein A, Odom R, Powell F (2002) Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol 46:584-587
25. Wilkin JK (1994) Rosacea. Pathophysiology and treatment. Arch Dermatol 130:359-362
26. Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL (2007) Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med 13:975-980 (Pubitemid 47222043)
27. Yamasaki K, Gallo RL (2009) The molecular pathology of rosacea. J Dermatol Sci 55:77-81
28. Yamasaki K, Kanada K, Macleod DT, Borkowski AW, Morizane S, Nakatsuji T, Cogen AL, Gallo RL (2011) TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 131:688-697