Effects of atomoxetine on cardiovascular functions and on QT dispersion in children with attention deficit hyperactivity disorder

Cardiology in the Young

Volumn 22, Issue 2, 2012, Pages 158-161

  Sert, Ahmet ^a   Gokcen, Cem ^b   Aypar, Ebru ^a   Odabas, Dursun ^a  

^a KONYA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

Echocardiography; norepinephrine reuptake inhibitor; QT interval

Indexed keywords

ATOMOXETINE;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG DOSE INCREASE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; FEMALE; HEART CONTRACTION; HEART EJECTION FRACTION; HEART LEFT VENTRICLE CONTRACTION; HEART PALPITATION; HEART RATE; HUMAN; MALE; OUTCOME ASSESSMENT; PRESYNCOPE; PROSPECTIVE STUDY; QT DISPERSION; QT INTERVAL; SCHOOL CHILD; SIDE EFFECT; SYNCOPE; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION;

ADOLESCENT; ADRENERGIC UPTAKE INHIBITORS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; CHILD; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; MALE; PROPYLAMINES; TURKEY;

EID: 84857885581     PISSN: 10479511     EISSN: 14671107     Source Type: Journal    
DOI: 10.1017/S1047951111001211     Document Type: Article

References (25)

1. Ralston SJ, Lorenzo MJ, ADORE Study Group. ADORE - Attention-Deficit Hyperactivity Disorder Observational Research in Europe. Eur Child Adolesc Psychiatr 2004; 13: 136-142.
2. Li WY, Strang SE, Brown DR, et al. Atomoxetine changes rat's HR response to stress from tachycardia to bradycardia via alterations in autonomic function. Auton Neurosci 2010; 154: 48-53.
3. Wernicke JF, Faries D, Girod D, et al. Cardiovascular effects of atomoxetine in children, adolescents, and adults. Drug Safe 2003; 26: 729-740. (Pubitemid 36976134)
4. Barr CS, Naas A, Freeman M, Lang CC, Struthers AD. QT Dispersion and sudden unexpected death in chronic heart failure. The Lancet 1994; 343: 327-329. (Pubitemid 24043180)
5. Merx W, Yoon MS, Han J. The role of local disparity in conduction and recovery time on ventricular vulnerability to fibrillation. Am Heart J 1977; 94: 603-610. (Pubitemid 8223535)
6. Etheridge SP, Shaddy RE. QT dispersion after beta-Tlocker therapy in children with heart failure. Am J Cardiol 2003; 91: 1-5.
7. Zabel M, Klingenheben T, Franz M, Hohnloser S. Assessment of QT dispersion for prediction of mortality or arrhythmic events after myocardial infarction. Circulation 1998; 97: 2543-2550.
8. Tutar HE, Ocal B, Imamoglu A, Atalay S. Dispersion of QT and QTc interval in healthy children, and effects of sinus arrhythmia on QT dispersion. Heart 1998; 80: 77-79. (Pubitemid 28351125)
9. Kaufman J, Birmaher B, Brent D. Schedule for affective disorders and schizophrenia for school age children - present and lifetime version (K-SADS-PL): Initial reliability and validity data. J Am Acad Child Adolesc Psychiatr 1997; 36: 980-988. (Pubitemid 27272932)
10. Bazett HC. An analysis of the time relations of electrocardiograms. Heart 1920; 7: 353.
11. Kimball TR, Michelfelder EC. Echocardiography. In: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF (eds). Moss and Adams' heart disease in infants, children, and adolescents: Including the fetus and young adult, 7th edn. Lippincott Williams & Wilkins, Philadelphia, PA, 2008, pp 95-163.
12. Walsh EP, Saul P. Cardiac arrhythmias. In: Fyler DC (ed.). Nadas' pediatric cardiology. Hanley and Belfus Inc., Philadelphia, PA, 1992, pp 377-434.
13. Bednar MM, Harrigan EP, Ruskin JN. Torsade de pointes associated with nonantiarrhythmic drugs and observations on gender and QTc. Am J Cardiol 2002; 89: 1316-1319. (Pubitemid 34606900)
14. Spencer T, Biederman J, Heiligenstein J, et al. An open label, dose-ranging study of atomoxetine in children with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 2001; 11: 251-265. (Pubitemid 32937637)
15. Kratochvil CJ, Wilens TE, Greenhill LL, et al. Effects of longterm atomoxetine treatment for young children with attentiondeficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatr 2006; 45: 919-927. (Pubitemid 44126866)
16. Allen AJ, Kurlan RM, Gilbert DL, et al. Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disorders. Neurology 2005; 65: 1941-1949. (Pubitemid 43970115)
17. Kautzner J, Malik M. QT interval dispersion and its clinical utility. Pacing Clin Electrophysiol 1997; 20: 2625-2640.
18. Statters DJ, Malik M, Ward DE, Camm AJ. QT dispersion: Problems of methodology and clinical significance. J Cardiovasc Electrophysiol 1994; 5: 672-685. (Pubitemid 24278192)
19. Davey PP, Bateman J, Mulligan IP, Forfar C, Barlow C, Hart G. QT interval dispersion in chronic heart failure and left ventricular hypertrophy: Relation to autonomic nervous system and Holter tape abnormalities. Br Heart J 1994; 71: 268-273. (Pubitemid 24113533)
20. Shah CP, Thakur RK, Reisdorff EJ, Lane E, Aufderheide TP, Hayes OW. QT dispersion may be a useful adjunct for detection of myocardial infarction in the chest pain center. Am Heart J 1998; 136: 496-498. (Pubitemid 28413549)
21. Day CP, McComb JM, Campbell RWF. QT dispersion: An indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990; 63: 342-344. (Pubitemid 20182179)
22. Grimm W, Steder U, Menz V, Hoffmann J, Maisch B. QT dispersion and arrhythmic events in idiopathic dilated cardiomyopathy. Am J Cardiol 1996; 78: 458-461. (Pubitemid 26277028)
23. Michelson D, Read HA, Ruff DD, Witcher J, Zhang S, McCracken J. CYP2D6 and clinical response to atomoxetine in children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatr 2007; 46: 242-251. (Pubitemid 46148423)
24. Spencer T, Heiligenstein JH, Biederman J, et al. Results from 2 proof-of-concept, placebo-controlled studies of atomoxetine in children with attention-deficit/hyperactivity disorder. J Clin Psychiatr 2002; 63: 1140-1147. (Pubitemid 36084059)
25. Donnelly C, Bangs M, Trzepacz P, et al. Safety and tolerability of atomoxetine over 3 to 4 years in children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatr 2009; 48: 176-185.