Enzyme-linked immunoassay for plasma-free metanephrines in the biochemical diagnosis of phaeochromocytoma in adults is not ideal

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 1, 2012, Pages 105-110

  Mullins, Fiona ^a   O'Shea, Paula ^b   FitzGerald, Roland ^a   Tormey, William ^a,c  

^a BEAUMONT HOSPITAL   (Ireland)

^b UNIVERSITY HOSPITAL GALWAY   (Ireland)

^c UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Bias; Fractionated plasma metanephrines; Immunoassay; Mass spectrometry; Phaeo chromocytoma; Sensitivity; Specificity

Indexed keywords

METADRENALIN; NORMETADRENALIN;

ANALYTIC METHOD; ARTICLE; CALIBRATION; CATECHOLAMINE BLOOD LEVEL; CATECHOLAMINE URINE LEVEL; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FRACTIONATION; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; PHEOCHROMOCYTOMA; PLASMA; PRIORITY JOURNAL; SCREENING TEST; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ADRENAL GLAND NEOPLASMS; DIAGNOSTIC ERRORS; HUMANS; IMMUNOENZYME TECHNIQUES; METANEPHRINE; NORMETANEPHRINE; PHEOCHROMOCYTOMA; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 84857882479     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.742     Document Type: Article

References (24)

1. Manger WM, Gifford RW. Pheochromocytoma. J Clin Hypertens (Greenwich) 2002; 4: 62-72. (Pubitemid 34163050)
2. Lenders JW, Pacak K, Walther MM, Linehan WM, Mannelli M, Friberg P, et al. Biochemical diagnosis of pheochromocytoma: which test is best? J Am Med Assoc 2002;287:1427-34. (Pubitemid 34250506)
3. Lenders JW, Keiser HR, Goldstein DS, Willemsen JJ, Friberg P, Jacobs MC, et al. Plasma metanephrines in the diagnosis of pheo-chromocytoma. Ann Intern Med 1995;123:101-9.
4. Eisenhofer G, Lenders JW, Pacak K. Choice of biochemical test for diagnosis of pheochromocytoma: validation of plasma meta-nephrines. Curr Hypertens Rep 2002;4:250-5.
5. Lenders JW, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet 2005;366:665-75. (Pubitemid 41176020)
6. Eisenhofer G, Goldstein DS, Kopin IJ, Crout JR. Pheochromocytoma: rediscovery as a catecholamine-metaboli-zing tumor. Endocr Pathol 2003;14:193-212.
7. Singh RJ, Eisenhofer G. High-throughput, automated, and accurate biochemical screening for pheochromocytoma: are we there yet? Clin Chem 2007;53:1565-7. (Pubitemid 47340049)
8. Peaston RT, Ball S. Biochemical detection of phaeochromocy-toma: why are we continuing to ignore the evidence? Ann Clin Biochem 2008;45:6-10. (Pubitemid 351724608)
9. Unger N, Deutschbein T, Walz MK, Mann K, Petersenn S. The value of immunoassays for metanephrines in the biochemical diagnosis of pheochromocytomas. Horm Metab Res 2009;41:676-9.
10. Peaston RT, Weinkove C. Measurement of catecholamines and their metabolites. Ann Clin Biochem 2004;41:17-38. (Pubitemid 38175092)
11. Peaston RT, Graham KS, Chambers E, van der Molen JC, Ball S. Performance of plasma free metanephrines measured by liquid chromatography-tandem mass spectrometry in the diagnosis of pheochromocytoma. Clin Chim Acta 2010;411:546-52.
12. Pacak K, Eisenhofer G, Ahlman H, Bornstein SR, Gimenez-Roqueplo AP, Grossman AB, et al. Pheochromocytoma: recommendations for clinical practice from the first international symposium. October 2005. Nat Clin Pract Endocrinol Metab 2007;3:92-102. (Pubitemid 46146962)
13. Hickman PE, Leong M, Chang J, Wilson SR, McWhinney B. Plasma free metanephrines are superior to urine and plasma catecholamines and urine catecholamine metabolites for the investigation of phaeochromocytoma. Pathology 2009;41:173-7.
14. Clinical and Laboratory Standards Institute (CLSI). User veri-fication of performance for precision and trueness; approved guideline. 2. CLSI document ep15-a2 (ISBN 1-56238-574-7). Wayne, PA: CLSI, 2005.
15. Passing H, Bablok W. A new biometrical procedure for testing the equality of measurements from two different analytical methods. Application of linear regression procedures for method comparison studies in clinical chemistry, part i. J Clin Chem Clin Biochem 1983;21:709-20. (Pubitemid 14208512)
16. Clinical and Laboratory Standards Institute (CLSI). Defining establishing and verifying reference intervals in the clinical laboratory; approved guideline-third edition clsi document c28-a3 (ISBN 1-56238-682-4). Wayne, PA: CLSI, 2008.
17. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983;148:839-43. (Pubitemid 13033817)
18. Eisenhofer G, Goldstein DS, Walther MM, Friberg P, Lenders JW, Keiser HR, et al. Biochemical diagnosis of pheochromocy-toma: how to distinguish true-from false-positive test results. J Clin Endocrinol Metab 2003;88:2656-66. (Pubitemid 36724439)
19. Perry CG, Sawka AM, Singh R, Thabane L, Bajnarek J, Young WF, Jr. The diagnostic efficacy of urinary fractionated meta-nephrines measured by tandem mass spectrometry in detection of pheochromocytoma. Clin Endocrinol (Oxf) 2007;66:703-8. (Pubitemid 46699545)
20. Sawka AM, Jaeschke R, Singh RJ, Young WF, Jr. A comparison of biochemical tests for pheochromocytoma: measurement of fractionated plasma metanephrines compared with the combination of 24-h urinary metanephrines and catecholamines. J Clin Endocrinol Metab 2003;88:553-8. (Pubitemid 36207789)
21. Lenders JW, Pacak K, Eisenhofer G. New advances in the biochemical diagnosis of pheochromocytoma: moving beyond cat-echolamines. Ann NY Acad Sci 2002;970:29-40. (Pubitemid 35286081)
22. Procopiou M, Finney H, Akker SA, Chew SL, Drake WM, Burrin J, et al. Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors. Eur J Endocrinol 2009;161:131-40.
23. Pillai D, Callen S. Pilot quality assurance programme for plasma metanephrines. Ann Clin Biochem 2010;47:137-42.
24. Pillai D, Ross HA, Kratzsch J, Pedrosa W, Kema I, Hoad K, et al. Proficiency test of plasma free and total metanephrines: report from a study group. Clin Chem Lab Med 2009;47:786-90.