Macrophage infiltration and smooth muscle cells content associated with haptoglobin genotype in human atherosclerotic carotid plaques

Angiology

Volumn 63, Issue 3, 2012, Pages 178-183

  Lioupis, Christos ^a   Barbatis, Calypso ^a   Lazari, Paraskevi ^a   Liasis, Nikolaos ^b   Klonaris, Christos ^b   Georgopoulos, Sotirios ^b   Andrikopoulos, Vasilios ^a   Bastounis, Elias ^b  

^a RED CROSS HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

carotid plaques; haptoglobin genotype; macrophages; smooth muscle cells; vulnerable plaque

Indexed keywords

ACTIN ANTIBODY; CD68 ANTIBODY; CD68 ANTIGEN; HAPTOGLOBIN; LYMPHOCYTE ANTIBODY; SMOOTH MUSCLE ACTIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CAROTID ATHEROSCLEROSIS; CAROTID ENDARTERECTOMY; CELL INFILTRATION; DIABETIC PATIENT; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MACROPHAGE INFILTRATION; MAJOR CLINICAL STUDY; MALE; SMOOTH MUSCLE FIBER;

CAROTID STENOSIS; COHORT STUDIES; ENDARTERECTOMY, CAROTID; FEMALE; GENOTYPE; HAPTOGLOBINS; HUMANS; MACROPHAGES; MALE; MYOCYTES, SMOOTH MUSCLE; PLAQUE, ATHEROSCLEROTIC;

EID: 84857840406     PISSN: 00033197     EISSN: 19401574     Source Type: Journal    
DOI: 10.1177/0003319711410051     Document Type: Article

References (39)

1. Virmani R, Finn AV, Kolodgie FD.. Carotid plaque stabilization and progression after stroke or TIA. Arterioscler Thromb Vasc Biol. 2009 ; 29 (1). 3-6
2. Carr SC, Farb A, Pearce WH, Virmani R, Yao JS.. Activated inflammatory cells are associated with plaque rupture in carotid artery stenosis. Surgery. 1997 ; 122 (4). 757-763
3. Seeger JM, Barratt E, Lawson GA, Klingman N.. The relationship between carotid plaque composition, plaque morphology, and neurologic symptoms. J Surg Res. 1995 ; 58 (3). 330-336
4. Virmani R, Burke AP, Farb A, Kolodgie FD.. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006 ; 47 (8)(suppl). C13 - C18
5. Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J.. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. Br Heart J. 1993 ; 69 (5). 377-381 (Pubitemid 23171108)
6. Shah PK, Falk E, Badimon JJ, et al. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation. 1995 ; 92 (6). 1565-1569
7. Burleigh MC, Briggs AD, Lendon CL, Davies MJ, Born GV, Richardson PD.. Collagen types I and III, collagen content, GAGs and mechanical strength of human atherosclerotic plaque caps: span-wise variations. Atherosclerosis. 1992 ; 96 (1). 71-81
8. van der Wal AC, Becker AE, van der Loos CM, Das PK.. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994 ; 89 (1). 36-44 (Pubitemid 24026469)
9. Kolodgie FD, Burke AP, Farb A, et al. The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes. Curr Opin Cardiol. 2001 ; 16 (5). 285-292 (Pubitemid 32953605)
10. Aidinian G, Weiswasser JM, Arora S, Abularrage CJ, Singh N, Sidawy AN.. Carotid plaque morphologic characteristics. Perspect Vasc Surg Endovasc Ther. 2006 ; 18 (1). 63-70
11. Levy AP, Asleh R, Blum S, et al. Haptoglobin: basic and clinical aspects. Antioxid Redox Signal. 2010 ; 12 (2). 293-304
12. Lioupis C, Barbatis C, Drougou A, et al. Association of haptoglobin genotype and common cardiovascular risk factors with the amount of iron in atherosclerotic carotid plaques. Atherosclerosis. 2011 ; 212 (1). 131-138
13. Stary HC.. Natural history and histological classification of atherosclerotic lesions: an update. Arterioscler Thromb Vasc Biol. 2000 ; 20 (5). 1177-1178 (Pubitemid 30262913)
14. Bowman BH, Kurosky A.. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet. 1982 ; 12: 189 453-261 454
15. Hochberg I, Roguin A, Nikolsky E, Chanderashekhar PV, Cohen S, Levy AP.. Haptoglobin phenotype and coronary artery collaterals in diabetic patients. Atherosclerosis. 2002 ; 161 (2). 441-446 (Pubitemid 34219199)
16. Wassell J, Keevil B.. A new method for haptoglobin phenotyping. Ann Clin Biochem. 1999 ; 36 (pt 5). 609-612 (Pubitemid 29410713)
17. Moreno PR, Purushothaman KR, Purushothaman M, et al. Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque. J Am Coll Cardiol. 2008 ; 52 (13). 1049-1051
18. Kockx MM, Cromheeke KM, Knaapen MW, et al. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 ; 23 (3). 440-446 (Pubitemid 36337220)
19. Virmani R, Kolodgie FD, Burke AP, et al. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol. 2005 ; 25 (10). 2054-2061 (Pubitemid 41416300)
20. Levy AP, Moreno PR.. Intraplaque hemorrhage. Curr Mol Med. 2006 ; 6 (5). 479-488
21. Rother RP, Bell L, Hillmen P, Gladwin MT.. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005 ; 293 (13). 1653-1662 (Pubitemid 40471796)
22. Miller YI, Altamentova SM, Shaklai N.. Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: antioxidant role of haptoglobin. Biochemistry. 1997 ; 36 (40). 12189-12198 (Pubitemid 27440956)
23. Bamm VV, Tsemakhovich VA, Shaklai M, Shaklai N.. Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL. Biochemistry. 2004 ; 43 (13). 3899-3906 (Pubitemid 38437056)
24. Melamed-Frank M, Lache O, Enav BI, et al. Structure-function analysis of the antioxidant properties of haptoglobin. Blood. 2001 ; 98 (13). 3693-3698
25. Asleh R, Miller-Lotan R, Aviram M, et al. Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo. Circ Res. 2006 ; 99 (12). 1419-1425 (Pubitemid 44949678)
26. Asleh R, Marsh S, Shilkrut M, et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease. Circ Res. 2003 ; 92 (11). 1193-1200 (Pubitemid 36723646)
27. Jeziorska M, Woolley DE.. Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries. J Pathol. 1999 ; 188 (2). 189-196 (Pubitemid 29253939)
28. Levy AP, Purushothaman KR, Levy NS, et al. Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability. Circ Res. 2007 ; 101 (1). 106-110 (Pubitemid 47094629)
29. Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation. 2003 ; 108 (15). 1772-1778 (Pubitemid 37296082)
30. Libby P.. Role of inflammation in atherosclerosis associated with rheumatoid arthritis. Am J Med. 2008 ; 121 (10)(suppl 1). S21 - S31
31. Kockx MM, Herman AG.. Apoptosis in atherogenesis: implications for plaque destabilization. Eur Heart J. 1998 ; 19 (suppl G). G23 - G28 (Pubitemid 28321430)
32. Koutouzis M, Paraskevas KI, Rallidis LS, et al. Statin treatment, carotid atherosclerotic plaque macrophage infiltration and circulating inflammatory markers. Open Cardiovasc Med J. 2008 ; 2: 110-114
33. Brownlee M.. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001 ; 414 (6865). 813-820 (Pubitemid 34000785)
34. Du X, Matsumura T, Edelstein D, et al. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest. 2003 ; 112 (7). 1049-1057 (Pubitemid 38056320)
35. Moreno PR, Purushothaman KR, Fuster V, O'Connor WN.. Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability. Circulation. 2002 ; 105 (21). 2504-2511 (Pubitemid 34568972)
36. Pasterkamp G, Schoneveld AH, Hijnen DJ, et al. Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteases 1, 2 and 9 in the human coronary artery. Atherosclerosis. 2000 ; 150 (2). 245-253 (Pubitemid 30336536)
37. Geng YJ, Wu Q, Muszynski M, Hansson GK, Libby P.. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler Thromb Vasc Biol. 1996 ; 16 (1). 19-27 (Pubitemid 26026927)
38. Levy AP, Gerstein HC, Miller-Lotan R, et al. The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes. Diabetes Care. 2004 ; 27 (11). 2767 (Pubitemid 39441487)
39. Daskalopoulou SS, Daskalopoulos ME, Theocharis S, et al. Metallothionein expression in the high-risk carotid atherosclerotic plaque. Curr Med Res Opin. 2007 ; 23 (3). 659-670 (Pubitemid 46456914)