Glucocorticosteroids differentially regulate MMP-9 and neutrophil elastase in COPD

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Vlahos, Ross ^a   Wark, Peter A B ^b   Anderson, Gary P ^a   Bozinovski, Steven ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DEXTRAN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GELATINASE B; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE; TOLL LIKE RECEPTOR AGONIST; WORTMANNIN; GLUCOCORTICOID;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE SEVERITY; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE ACTIVATION; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SECRETION; SECRETORY PATHWAY; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; ANIMAL; BAGG ALBINO MOUSE; DISEASE COURSE; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; IMMUNOLOGY; INFLAMMATION; METABOLISM; MIDDLE AGED; NEUTROPHIL;

MUS;

AGED; AGED, 80 AND OVER; ANIMALS; DISEASE PROGRESSION; DRUG RESISTANCE; FEMALE; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; LEUKOCYTE ELASTASE; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; MIDDLE AGED; NEUTROPHIL ACTIVATION; NEUTROPHILS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84857823945     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033277     Document Type: Article

References (40)

1. Taggart CC, Greene CM, Carroll TP, O'Neill SJ, McElvaney NG, (2005) Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease. Am J Respir Crit Care Med 171: 1070-1076.
2. Owen CA, (2008) Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 3: 253-268.
3. Pauwels RA, Rabe KF, (2004) Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364: 613-620.
4. Donaldson GC, Seemungal TA, Patel IS, Lloyd-Owen SJ, Wilkinson TM, et al. (2003) Longitudinal changes in the nature, severity and frequency of COPD exacerbations. Eur Respir J 22: 931-936.
5. Sethi S, Murphy TF, (2008) Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med 359: 2355-2365.
6. Culpitt SV, Maziak W, Loukidis S, Nightingale JA, Matthews JL, et al. (1999) Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160: 1635-1639.
7. Beeh KM, Beier J, Kornmann O, Buhl R, (2003) Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects. Respir Med 97: 634-639.
8. Culpitt SV, Rogers DF, Traves SL, Barnes PJ, Donnelly LE, (2005) Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma. Respir Med 99: 703-710.
9. Faurschou M, Borregaard N, (2003) Neutrophil granules and secretory vesicles in inflammation. Microbes Infect 5: 1317-1327.
10. Masure S, Proost P, Van Damme J, Opdenakker G, (1991) Purification and identification of 91-kDa neutrophil gelatinase. Release by the activating peptide interleukin-8. Eur J Biochem 198: 391-398.
11. Xu X, Jackson PL, Tanner S, Hardison MT, Abdul Roda M, et al. (2011) A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation. PLoS One 6: e15781.
12. Damiano VV, Tsang A, Kucich U, Abrams WR, Rosenbloom J, et al. (1986) Immunolocalization of elastase in human emphysematous lungs. J Clin Invest 78: 482-493.
13. Laurell CB, Eriksson S, (1963) The electrophoretic alpha-1-globulin pattern of serum in alpha-1-antitrypsin defi ciency. Scand J Clin Lab Invest pp. 132-140.
14. Ferry G, Lonchampt M, Pennel L, de Nanteuil G, Canet E, et al. (1997) Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury. FEBS Lett 402: 111-115.
15. Itoh Y, Nagase H, (1995) Preferential inactivation of tissue inhibitor of metalloproteinases-1 that is bound to the precursor of matrix metalloproteinase 9 (progelatinase B) by human neutrophil elastase. J Biol Chem 270: 16518-16521.
16. Devaney JM, Greene CM, Taggart CC, Carroll TP, O'Neill SJ, et al. (2003) Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Lett 544: 129-132.
17. Yan C, Wang H, Aggarwal B, Boyd DD, (2004) A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. FASEB J 18: 540-541.
18. Bozinovski S, Hutchinson A, Thompson M, Macgregor L, Black J, et al. (2008) Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 177: 269-278.
19. Ehrenfeld P, Matus CE, Pavicic F, Toledo C, Nualart F, et al. (2009) Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family. J Leukoc Biol 86: 1179-1189.
20. Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, et al. (2001) Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 69: 851-859.
21. Chakrabarti S, Zee JM, Patel KD, (2006) Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release. J Leukoc Biol 79: 214-222.
22. Pugin J, Widmer MC, Kossodo S, Liang CM, Preas HLn, et al. (1999) Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators. Am J Respir Cell Mol Biol 20: 458-464.
23. Opdenakker G, Fibbe WE, Van Damme J, (1998) The molecular basis of leukocytosis. Immunol Today 19: 182-189.
24. Pruijt JF, Fibbe WE, Laterveer L, Pieters RA, Lindley IJ, et al. (1999) Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9). Proc Natl Acad Sci U S A 96: 10863-10868.
25. Pham CT, (2006) Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol 6: 541-550.
26. Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, et al. (1998) Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med 4: 615-618.
27. Owen CA, Campbell MA, Sannes PL, Boukedes SS, Campbell EJ, (1995) Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J Cell Biol 131: 775-789.
28. Naylor EJ, Bakstad D, Biffen M, Thong B, Calverley P, et al. (2007) Haemophilus influenzae induces neutrophil necrosis: a role in chronic obstructive pulmonary disease? Am J Respir Cell Mol Biol 37: 135-143.
29. Chakrabarti S, Patel KD, (2005) Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils. J Leukoc Biol 78: 279-288.
30. Salaun C, James DJ, Greaves J, Chamberlain LH, (2004) Plasma membrane targeting of exocytic SNARE proteins. Biochim Biophys Acta 1693: 81-89.
31. Ryder MI, (1994) Nicotine effects on neutrophil F-actin formation and calcium release: implications for tobacco use and pulmonary diseases. Exp Lung Res 20: 283-296.
32. Russell RE, Culpitt SV, DeMatos C, Donnelly L, Smith M, et al. (2002) Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 26: 602-609.
33. Barnes PJ, Ito K, Adcock IM, (2004) Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 363: 731-733.
34. Walsh DE, Greene CM, Carroll TP, Taggart CC, Gallagher PM, et al. (2001) Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium. J Biol Chem 276: 35494-35499.
35. Kuwahara I, Lillehoj EP, Lu W, Singh IS, Isohama Y, et al. (2006) Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line. Am J Physiol Lung Cell Mol Physiol 291: L407-416.
36. Shao MX, Nadel JA, (2005) Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol 175: 4009-4016.
37. Liu K, Gualano RC, Hibbs ML, Anderson GP, Bozinovski S, (2008) Epidermal growth factor receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus infection. J Biol Chem 283: 9977-9985.
38. Bozinovski S, Jones JE, Vlahos R, Hamilton JA, Anderson GP, (2002) Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo. J Biol Chem 277: 42808-42814.
39. Vlahos R, Bozinovski S, Jones JE, Powell J, Gras J, et al. (2006) Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice. Am J Physiol Lung Cell Mol Physiol 290: L931-945.
40. Bozinovski S, Cross M, Vlahos R, Jones JE, Hsuu K, et al. (2005) S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. J Proteome Res 4: 136-145.