Significance of tumor-infiltrating immune cells in spontaneous canine mammary gland tumor: 140 cases

Journal of Veterinary Medical Science

Volumn 74, Issue 2, 2012, Pages 227-230

  Saeki, Kohei ^a   Endo, Yoshifumi ^a   Uchida, Kazuyuki ^a   Nishimura, Ryohei ^a   Sasaki, Nobuo ^a   Nakagawa, Takayuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Canine; CD3; Mammary gland tumor; Microenvironment; Tumor infiltrating leukocyte

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; CD8+ T LYMPHOCYTE; CHI SQUARE DISTRIBUTION; DOG; DOG DISEASE; EXPERIMENTAL NEOPLASM; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; KAPLAN MEIER METHOD; TUMOR ASSOCIATED LEUKOCYTE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHI-SQUARE DISTRIBUTION; DOG DISEASES; DOGS; FEMALE; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHOCYTES, TUMOR-INFILTRATING; MAMMARY NEOPLASMS, ANIMAL;

EID: 84857822520     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.11-0118     Document Type: Article

References (34)

1. Allavena, P., Sica, A., Garlanda, C. and Mantovani, A. 2008. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol. Rev. 222: 155-161.
2. Al-Shibli, K., Al-Saad, S., Andersen, S., Donnem, T., Bremnes, R. M. and Busund, L. T. 2010. The prognostic value of intraepithelial and stromal CD3-, CD117- and CD138-positive cells in non-small cell lung carcinoma. Acta Pathol. Microbiol. Immunol. Scand. A 118: 371-382.
3. Amorim, R. L., Pinczowski, P., Neto, R. T. and Rahal, S. C. 2010. Immunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours. Vet. Comp. Oncol. 8: 23-27.
4. Balkwill, F. and Mantovani, A. 2001. Inflammation and cancer: back to Virchow? Lancet 357: 539-545.
5. Coronella-Wood, J. A. and Hersh, E. M. 2003. Naturally occurring B-cell responses to breast cancer. Cancer Immunol. Immunother. 52: 715-738.
6. DeNardo, D. G. and Coussens, L. M. 2007. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res. 9: 212-221.
7. Dorn, C. R., Taylor, D. O., Schneider, R., Hibbard, H. H. and Klauber, M. R. 1968. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J. Natl. Cancer Inst. 40: 307-318.
8. Estrela-Lima, A., Araújo, M. S., Costa-Neto, J. M., Teixeira-Carvalho, A., Barrouin-Melo, S. M., Cardoso, S. V., Martins-Filho, O. A., Serakides, R. and Cassali, G. D. 2010. Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates. BMC cancer 10: 256-269.
9. Fernandez, M. F. 2005. Autoantibodies in breast cancer sera: candidate biomarkers and reporters of tumorigenesis. Cancer Lett. 230: 187-198.
10. Grivennikov, S. I., Greten, F. R. and Karin, M. 2010. Immunity, inflammation, and cancer. Cell 140: 883-899.
11. Han, L.Y., Fletcher, M.S., Urbauer, D.L., Mueller, P., Landen, C.N., Kamat, A.A., Lin, Y.G., Merritt, W.M., Spannuth, W.A., Deavers, M.T., De Geest, K., Gershenson, D.M., Lutgendorf, S.K., Ferrone, S. and Sood, A.K. 2008. HLA class I antigen processing machinery component expression and intratumoral T-Cell infiltrate as independent prognostic markers in ovarian carcinoma. Clin. Cancer Res. 14: 3372-3379.
12. Hellmen, E., Bergstrom, R., Holmberg, L., Spangberg, I. B., Hansson, K. and Lindgren, A. 1993. Prognostic factors in canine mammary tumors: a multivariate study of 202 consecutive cases. Vet. Pathol. 30: 20-27.
13. Horiuchi, Y., Tominaga, M., Ichikawa, M., Yamashita, M., Jikumaru, Y., Nariai, Y., Nakajima, Y., Kuwabara, M. and Yukawa, M. 2009. Increase of regulatory T cells in the peripheral blood of dogs with metastatic tumors. Microbiol. Immunol. 53: 468-474.
14. Itoh, T., Uchida, K., Ishikawa, K., Kushima, K., Kushima, E., Tamada, H., Moritake, T., Nakao, H. and Shii, H. 2005. Clinicopathological survey of 101 canine mammary gland tumors: differences between small-breed dogs and others. J. Vet. Med. Sci. 67: 345-347.
15. Joyce, J. A. and Pollard, J. W. 2009. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9: 239-252.
16. Kim, J. H., Yu, C. H., Yhee, J. Y., Im, K. S. and Sur, J. H. 2010. Lymphocyte infiltration, expression of interleukin (IL)-1, IL-6 and expression of mutated breast cancer susceptibility gene-1 correlate with malignancy of canine mammary tumours. J. Comp. Pathol. 142: 177-186.
17. + regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin. Cancer Res. 13: 902-911.
18. Kumaraguruparan, R., Prathiba, D. and Nagini, S. 2006. Of humans and canines: Immunohistochemical analysis of PCNA, Bcl-2, p53, cytokeratin and ER in mammary tumours. Res. Vet. Sci. 81: 218-224.
19. Kumaraguruparan, R., Karunagaran, D., Balachandran, C., Manohar, B. M. and Nagini, S. 2006. Of humans and canines: a comparative evaluation of heat shock and apoptosis-associated proteins in mammary tumors. Clin. Chim. Acta 365: 168-176.
20. Lana, E. L., Rutteman, G. R. and Withrow, S. J. 2007. Tumors of mammary gland. pp. 619-636. In: Small Animal Clinical Oncology, 4th ed. (Withrow, S. J. and Vail D. M. eds.), Saunders, Philadelphia.
21. Mantovani, A., Marchesi, F., Porta, C., Sica, A. and Allavena, P. 2007. Inflammation and cancer: breast cancer as a prototype. Breast 16: S27-33.
22. Marrogi, A. J., Munshi, A., Merogi, A. J., Ohadike, Y., El-Habashi, A., Marrogi, O. L. and Freeman, S. M. 1997. Study of tumor infiltrating lymphocytes and transforming growth factorbeta as prognostic factors in breast carcinoma. Int. J. Cancer 74: 492-501.
23. Menegaz, R. A., Michelin, M. A., Etchebehere, R. M., Fernandes, P. C. and Murta, E. F. 2008. Peri- and intratumoral T and B lymphocytic infiltration in breast cancer. Eur. J. Gynaecol. Oncol. 29: 321-326.
24. Misdorp, W., Else, R. W., Hellmen, E. and Lipscomb, T. P. 1999. Histological Classification of Mammary Tumors of the Dog and Cat, Armed Forces Institute of Pathology, Washington D.C.
25. Moe, L. 2001. Population-based incidence of mammary tumours in some dog breeds. J. Reprod. Fertil. 57: 439-443.
26. Mukaratirwa, S., Chikafa, L., Dliwayo, R. and Moyo, N. 2006. Mast cells and angiogenesis in canine melanomas: malignancy and clinicopathological factors. Vet. Dermatol. 17: 141-146.
27. Murdoch, C., Muthana, M., Coffelt, S. B. and Lewis, C. E. 2008. The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8: 618-631.
28. Philibert, J. C., Snyder, P. W., Glickman, N., Glickman, L. T., Knapp, D. W. and Waters, D. J. 2003. Influence of host factors on survival in dogs with malignant mammary gland tumors. J. Vet. Intern. Med. 17: 102-106.
29. Ropponen, K. M., Eskelinen, M. J., Lipponen, P. K., Alhava, E. and Kosma, V. M. 1997. Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J. Pathol. 182: 318-324.
30. Tan, E. M. and Shi, F. D. 2003. Relative paradigms between autoantibodies in lupus and autoantibodies in cancer. Clin. Exp. Immunol. 134: 169-177.
31. Tefany, F. J., Barnetson, R. S., Halliday, G. M., McCarthy, S. W. and McCarthy, W. H. 1992. Immunocytochemical Analysis of the cellular infiltrate in primary regressing and non-regressing malignant melanoma. J. Invest. Dermatol. 97: 197-202.
32. Uva, P., Aurisicchio, L., Watters, J., Loboda, A., Kulkarni, A., Castle, J., Palombo, F., Viti, V., Mesiti, G., Zappulli, V., Marconato, L., Abramo, F., Ciliberto, G., Lahm, A., Monica, N. L. and Rinaldis, E. D. 2009. Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics 10: 135-154.
33. Visser, K. D., Eichten, A. and Coussens, L. M. 2006. Paradoxical roles of the immune system during cancer development. Nat. Rev. Cancer 6: 24-37.
34. Wong, P. Y., Staren, E. D., Tereshkova, N. and Braun, D. P. 1998. Functional analysis of tumor-infiltrating leukocytes in breast cancer patients. J. Surg. Res. 76: 95-103.