High-frequency vagus nerve stimulation improves portal hypertension in cirrhotic rats

Gut

Volumn 61, Issue 4, 2012, Pages 604-612

  Bockx, Ilse ^a   Verdrengh, Katrien ^a   Vander Elst, Ingrid ^a   Van Pelt, Jos ^a   Nevens, Frederik ^a   Laleman, Wim ^a   Cassiman, David ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; NITRIC OXIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; HEPATIC BRANCH VAGOTOMY; HORMONE RELEASE; IN VIVO STUDY; LIVER BLOOD FLOW; LIVER CIRRHOSIS; MALE; MEAN ARTERIAL PRESSURE; NEUROTRANSMISSION; NONHUMAN; PERFUSION PRESSURE; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; VAGOTOMY; VAGUS NERVE STIMULATION; VIPERGIC NEUROTRANSMISSION;

ACETYLCHOLINE; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERTENSION, PORTAL; LIVER CIRCULATION; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MICROCIRCULATION; MICROSPHERES; PORTAL PRESSURE; RATS; RATS, WISTAR; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE, TYPE II; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; VAGUS NERVE; VAGUS NERVE STIMULATION; VASOACTIVE INTESTINAL PEPTIDE; VASODILATOR AGENTS;

EID: 84857801492     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-301396     Document Type: Article

References (35)

1. Laleman W, Landeghem L, Wilmer A, et al. Portal hypertension: from pathophysiology to clinical practice. Liver Int 2005;25:1079-90. (Pubitemid 41782549)
2. Koo A, Liang IY. Parasympathetic cholinergic vasodilator mechanism in the terminal liver microcirculation in rats. Q J Exp Physiol Cogn Med Sci 1979;64:149-59. (Pubitemid 10221869)
3. Koo A, Liang IY. Stimulation and blockade of cholinergic receptors in terminal liver microcirculation in rats. Am J Physiol 1979;236:E728-32. (Pubitemid 9220555)
4. Lee SS, Sharkey KA. Capsaicin treatment blocks development of hyperkinetic circulation in portal hypertensive and cirrhotic rats. Am J Physiol 1993;264: G868-73. (Pubitemid 23155324)
5. Song D, Liu H, Sharkey KA, et al. Hyperdynamic circulation in portalhypertensive rats is dependent on central c-fos gene expression. Hepatology 2002;35:159-66. (Pubitemid 34032556)
6. Liu H, Schuelert N, McDougall JJ, et al. Central neural activation of hyperdynamic circulation in portal hypertensive rats depends on vagal afferent nerves. Gut 2008;57:966-73. (Pubitemid 351919531)
7. Laleman W, Vander Elst I, Zeegers M, et al. A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited. Eur J Clin Invest 2006;36:242-9.
8. Cassiman D, Libbrecht L, Sinelli N, et al. The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3. Am J Pathol 2002;161:521-30. (Pubitemid 36142161)
9. Agoston DV, Conlon JM, Whittaker VP. Selective depletion of the acetylcholine and vasoactive intestinal polypeptide of the guinea-pig myenteric plexus by differential mobilization of distinct transmitter pools. Exp Brain Res 1988;72:535-42.
10. Yokotani K, Okuma Y, Nakamura K, et al. Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors. J Pharmacol Exp Ther 1993;266:1190-5. (Pubitemid 24175759)
11. Lundberg JM. Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands. Morphological, biochemical and functional studies. Acta Physiol Scand Suppl 1981;496:1-57.
12. Feliciano L, Henning RJ. Vagal nerve stimulation releases vasoactive intestinal peptide which significantly increases coronary artery blood flow. Cardiovasc Res 1998;40:45-55. (Pubitemid 28435428)
13. Grider JR, Cable MB, Said SI, et al. Vasoactive intestinal peptide as a neural mediator of gastric relaxation. Am J Physiol 1985;248:G73-8. (Pubitemid 15127407)
14. Boeckxstaens GE, Pelckmans PA, Bogers JJ, et al. Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus. J Pharmacol Exp Ther 1991;256:441-7.
15. Takahashi T, Owyang C. Vagal control of nitric oxide and vasoactive intestinal polypeptide release in the regulation of gastric relaxation in rat. J Physiol 1995;484:481-92.
16. Gourlet P, De Neef P, Cnudde J, et al. In vitro properties of a high affinity selective antagonist of the VIP1 receptor. Peptides 1997;18:1555-60. (Pubitemid 28132998)
17. Moreno D, Gourlet P, De Neef P, et al. Development of selective agonists and antagonists for the human vasoactive intestinal polypeptide VPAC(2) receptor. Peptides 2000;21:1543-9.
18. Moro O, Wakita K, Ohnuma M, et al. Functional characterization of structural alterations in the sequence of the vasodilatory peptide maxadilan yields a pituitary adenylate cyclase-activating peptide type 1 receptor-specific antagonist. J Biol Chem 1999;13:23103-10.
19. Braet F, De Zanger R, Sasaoki T, et al. Assessment of a method of isolation, purification, and cultivation of rat liver sinusoidal endothelial cells. Lab Invest 1994;70:944-52. (Pubitemid 24209496)
20. Ishihara T, Shigemoto R, Mori K, et al. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron 1992;8:811-19.
21. Krejci A, Tucek S. Quantitation of mRNAs for M(1) to M(5) subtypes of muscarinic receptors in rat heart and brain cortex. Mol Pharmacol 2002;61:1267-72. (Pubitemid 34575735)
22. Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest 2007;117:289-96. (Pubitemid 46203953)
23. Armour JA, Randall WC. Rebound cardiovascular responses following stimulation of canine vagosympathetic complexes or cardiopulmonary nerves. Can J Physiol Pharmacol 1985;63:1122-32. (Pubitemid 16228539)
24. Furchgott RF. Role of endothelium in responses of vascular smooth muscle. Circ Res 1983;53:557-73. (Pubitemid 14248481)
25. Panza JA, Quyyumi AA, Brush JE, et al. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22-7. (Pubitemid 20209468)
26. Conraads VM, Bosmans JM, Claeys MJ, et al. Paradoxic pulmonary vasoconstriction in response to acetylcholine in patients with primary pulmonary hypertension. Chest 1994;106:385-90. (Pubitemid 24252030)
27. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6. (Pubitemid 11169009)
28. Iwakiri Y, Groszmann RJ. Vascular endothelial dysfunction in cirrhosis. J Hepatol 2007;46:927-34. (Pubitemid 46529052)
29. Gupta TK, Toruner M, Chung MK, et al. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. Hepatology 1998;28:926-31. (Pubitemid 28450251)
30. Duckles SP, Said SI. Vasoactive intestinal peptide as a neurotransmitter in the cerebral circulation. Eur J Pharmacol 1982;78:371-4. (Pubitemid 12190700)
31. D'Orleans-Juste P, Dion S, Mizrahi J, et al. Effects of peptides and non-peptides on isolated arterial smooth muscles: role of endothelium. Eur J Pharmacol 1985;114:9-21. (Pubitemid 16256596)
32. Beny JL, Brunet PC, Huggel H. Effect of mechanical stimulation, substance P and vasoactive intestinal polypeptide on the electrical and mechanical activities of circular smooth muscles from pig coronary arteries contracted with acetylcholine: role of endothelium. Pharmacology 1986;33:61-8. (Pubitemid 16077743)
33. Varga G, Kiss JZ, Papp M, et al. Vasoactive intestinal peptide may participate in the vasodilation of the dog hepatic artery. Am J Physiol 1986;251:G280-4.
34. Henning RJ, Sawmiller DR. Vasoactive intestinal peptide: cardiovascular effects. Cardiovasc Res 2001;49:27-37.
35. Dickson L, Finlayson K. VPAC and PAC receptors: from ligands to function. Pharm Ther 2009;121:294-316.