How stereological analysis of vascular morphology can quantify the blood volume fraction as a marker for tumor vasculature: Comparison with magnetic resonance imaging

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 3, 2012, Pages 489-501

  Perles Barbacaru, Adriana T ^a,b   Van Der Sanden, Boudewijn P J ^a,b   Farion, Regine ^a,b   Lahrech, Hana ^a,b  

^a UNIV GRENOBLE ALPES   (France)

^b INSERM   (France)

Author keywords

blood volume fraction; RSST1 MRI; stereology; vascular volume fraction; vessel diameter

Indexed keywords

ALPHA CYCLODEXTRIN; GADOTERATE MEGLUMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VOLUME; BLOOD VOLUME FRACTION; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; BRAIN PERFUSION; BRAIN REGION; BRAIN TISSUE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MARKER; GLIOMA; HISTOPATHOLOGY; IMAGE ANALYSIS; MICROVASCULATURE; MORPHOMETRICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; STEREOLOGY; THREE DIMENSIONAL IMAGING; TUMOR VASCULARIZATION;

ANIMALS; BLOOD VOLUME; BLOOD VOLUME DETERMINATION; BRAIN MAPPING; BRAIN NEOPLASMS; CELL LINE, TUMOR; CONTRAST MEDIA; GLIOMA; HETEROCYCLIC COMPOUNDS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MICROSCOPY, FLUORESCENCE; MICROVESSELS; MODELS, ANATOMIC; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; ORGANOMETALLIC COMPOUNDS; RATS; RATS, WISTAR;

EID: 84857794218     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.151     Document Type: Article

References (40)

1. Adair TH, Wells ML, Hang J, Montani JP (1994) A stereological method for estimating length density of the arterial vascular system. Am J Physiol 266: H1434-8
2. Adam JF, Elleaume H, Le Duc G, Corde S, Charvet AM, Tropres I, Le Bas JF, Esteve F (2003) Absolute cerebral blood volume and blood flow measurements based on synchrotron radiation quantitative computed tomography. J Cereb Blood Flow Metab 23:499-512
3. Adam JF, Nemoz C, Bravin A, Fiedler S, Bayat S, Monfraix S, Berruyer G, Charvet AM, Le Bas JF, Elleaume H, Esteve F (2005) High-resolution bloodbrain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma. J Cereb Blood Flow Metab 25:145-53
4. Aronen HJ, Gazit IE, Louis DN, Buchbinder BR, Pardo FS, Weisskoff RM, Harsh GR, Cosgrove GR, Halpern EF, Hochberg FH (1994) Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 191:41-51
5. Bereczki D, Wei L, Acuff V, Gruber K, Tajima A, Patlak C, Fenstermacher J (1992) Technique-dependent variations in cerebral microvessel blood volumes and hematocrits in the rat. J Appl Physiol 73:918-24
6. Bernsen HJ, Rijken PF, Hagemeier NE, van der Kogel AJ (1999) A quantitative analysis of vascularization and perfusion of human glioma xenografts at different implantation sites. Microvasc Res 57:244-57
7. Bernsen HJ, Rijken PF, Oostendorp T, van der Kogel AJ (1995) Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse. Br J Cancer 71:721-6
8. Deane BR, Lantos PL (1981) The vasculature of experimental brain tumours. Part 2. A quantitative assessment of morphological abnormalities. J Neurol Sci 49:67-77
9. Dennie J, Mandeville JB, Boxerman JL, Packard SD, Rosen BR, Weisskoff RM (1998) NMR imaging of changes in vascular morphology due to tumor angiogenesis. Magn Reson Med 40:793-9
10. Douma K, Oostendorp M, Slaaf DW, Post MJ, Backes WH, van Zandvoort MA (2010) Evaluation of magnetic resonance vessel size imaging by two-photon laser scanning microscopy. Magn Reson Med 63:930-9
11. Dunn JF, Roche MA, Springett R, Abajian M, Merlis J, Daghlian CP, Lu SY, Makki M (2004) Monitoring angiogenesis in brain using steady-state quantification of DeltaR2 with MION infusion. Magn Reson Med 51:55-61
12. Farrell CL, Farrell CR, Stewart PA, Del Maestro RF, Ellis CG (1991) The functional microcirculation in a glioma model. Int J Radiat Biol 60:131-7
13. Hawighorst H, Weikel W, Knapstein PG, Knopp MV, Zuna I, Schonberg SO, Vaupel P, van Kaick G (1998) Angiogenic activity of cervical carcinoma: assessment by functional magnetic resonance imaging-based parameters and a histomorphological approach in correlation with disease outcome. Clin Cancer Res 4:2305-12
14. Hennig A (1969) [Errors in volume determination from area relation of thick sections (Holmes effect)]. Mikroskopie 25:154-74
15. Jain AK (1989) Fundamentals of Digital Image Processing. New York, NY: Prentice-Hall Englewood Cliffs
16. Jain RK (1988) Determinants of tumor blood flow: a review. Cancer Res 48:2641-58
17. Jain RK (2001) Delivery of molecular and cellular medicine to solid tumors. Adv Drug Deliv Rev 46:149-68
18. Julien C, Payen JF, Tropres I, Farion R, Grillon E,Montigon O, Remy C (2004) Assessment of vascular reactivity in rat brain glioma by measuring regional blood volume during graded hypoxic hypoxia. Br J Cancer 91:374-80
19. Julien-Dolbec C, Tropres I, Montigon O, Reutenauer H, Ziegler A, Decorps M, Payen JF (2002) Regional response of cerebral blood volume to graded hypoxic hypoxia in rat brain. Br J Anaesth 89:287-93
20. Lahrech H, Perles-Barbacaru AT, Aous S, Le Bas JF, Debouzy JC, Gadelle A, Fries PH (2008) Cerebral blood volume quantification in a C6 tumor model using gadolinium per (3,6-anhydro) alpha-cyclodextrin as a new magnetic resonance imaging preclinical contrast agent. J Cereb Blood Flow Metab 28:1017-29
21. Lin W, Celik A, Paczynski RP, Hsu CY, Powers WJ (1999) Quantitative magnetic resonance imaging in experimental hypercapnia: improvement in the relation between changes in brain R2 and the oxygen saturation of venous blood after correction for changes in cerebral blood volume. J Cereb Blood Flow Metab 19:853-62
22. Lin W, Paczynski RP, Kuppusamy K, Hsu CY, Haacke EM (1997) Quantitative measurements of regional cerebral blood volume using MRI in rats: effects of arterial carbon dioxide tension and mannitol. Magn Reson Med 38:420-8
23. Otsu N (1979) A thresholding selection method from graylevel histogram. IEEE Trans Syst Man Cybern 9:62-6
24. Pathak AP, Rand SD, Schmainda KM (2003) The effect of brain tumor angiogenesis on the in vivo relationship between the gradient-echo relaxation rate change (DeltaR2*) and contrast agent (MION) dose. J Magn Reson Imaging 18:397-403
25. Pathak AP, Schmainda KM, Ward BD, Linderman JR, Rebro KJ, Greene AS (2001) MR-derived cerebral blood volume maps: issues regarding histological validation and assessment of tumor angiogenesis. Magn Reson Med 46:735-47
26. Payen JF, Briot E, Tropres I, Julien-Dolbec C, Montigon O, Decorps M (2000) Regional cerebral blood volume response to hypocapnia using susceptibility contrast MRI. NMR Biomed 13:384-91
27. Perles-Barbacaru AT, Lahrech H (2007) A new magnetic resonance imaging method for mapping the cerebral blood volume fraction: the rapid steady-state T1 method. J Cereb Blood Flow Metab 27:618-31
28. Rijken PF, Bernsen HJ, van der Kogel AJ (1995) Application of an image analysis system to the quantitation of tumor perfusion and vascularity in human glioma xenografts. Microvasc Res 50:141-53
29. Schlageter KE, Molnar P, Lapin GD, Groothuis DR (1999) Microvessel organization and structure in experimental brain tumors: microvessel populations with distinctive structural and functional properties. Microvasc Res 58:312-28
30. Schwarzbauer C, Morrissey SP, Deichmann R, Hillenbrand C, Syha J, Adolf H, Noth U, Haase A (1997) Quantitative magnetic resonance imaging of capillary water permeability and regional blood volume with an intravascular MR contrast agent. Magn Reson Med 37:769-77
31. Shockley RP, LaManna JC (1988) Determination of rat cerebral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia and hyperventilation. Brain Res 454:170-8
32. Todd MM, Weeks J (1996) Comparative effects of propofol, pentobarbital, and isoflurane on cerebral blood flow and blood volume. J Neurosurg Anesthesiol 8: 296-303
33. Todd MM, Weeks JB, Warner DS (1992) Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats. Am J Physiol 263:H75-82
34. Todd MM, Weeks JB, Warner DS (1993) The influence of intravascular volume expansion on cerebral blood flow and blood volume in normal rats. Anesthesiology 78:945-53
35. Tropres I, Grimault S, Vaeth A, Grillon E, Julien C, Payen JF, Lamalle L, Decorps M (2001) Vessel size imaging. Magn Reson Med 45:397-408
36. Tropres I, Lamalle L, Peoc'h M, Farion R, Usson Y, Decorps M, Remy C (2004) In vivo assessment of tumoral angiogenesis. Magn Reson Med 51:533-41
37. Valable S, Lemasson B, Farion R, Beaumont M, Segebarth C, Remy C, Barbier EL (2008) Assessment of blood volume, vessel size, and the expression of angiogenic factors in two rat glioma models: a longitudinal in vivo and ex vivo study. NMR Biomed 21:1043-56
38. Van der Sanden BP, Rozijn TH, Rijken PF, Peters HP, Heerschap A, van der Kogel AJ, Bovee WM (2000) Noninvasive assessment of the functional neovasculature in 9 L-glioma growing in rat brain by dynamic 1H magnetic resonance imaging of gadolinium uptake. J Cereb Blood Flow Metab 20:861-70
39. Verant P, Serduc R, Van Der Sanden B, Remy C, Vial JC (2007) A direct method for measuring mouse capillary cortical blood volume using multiphoton laser scanning microscopy. J Cereb Blood Flow Metab 27:1072-81
40. Weiss HR, Buchweitz E, Murtha TJ, Auletta M (1982) Quantitative regional determination of morphometric indices of the total and perfused capillary network in the rat brain. Circ Res 51:494-503