Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Tissue Antigens

Volumn 79, Issue 4, 2012, Pages 247-248

  Futas, J ^a   Vychodilova, L ^a   Hofmanova, B ^b   Vranova, M ^a   Putnova, L ^c   Muzik, J ^d   Vyskocil, M ^a   Vrtkova, I ^c   Dusek, L ^d   Majzlik, I ^b   Horin, P ^a  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^b CZECH UNIVERSITY OF LIFE SCIENCES PRAGUE   (Czech Republic)

^c MENDEL UNIVERSITY IN BRNO   (Czech Republic)

^d MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Association analysis; Greying horse; Melanoma; Microsatellites; Single nucleotide polymorphisms

Indexed keywords

MEMBRANE PROTEIN; SYNTAXIN 17; UNCLASSIFIED DRUG;

BREEDING; DNA POLYMORPHISM; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC RESISTANCE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; GENOTYPE; HETEROZYGOTE; HORSE DISEASE; LETTER; MELANOMA; MICROSATELLITE MARKER; NONHUMAN; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC;

AGE FACTORS; ANIMALS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HORSE DISEASES; HORSES; MELANOMA;

EQUIDAE;

EID: 84857793992     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2011.01827.x     Document Type: Letter

References (7)

1. Smith SH, Goldschmidt MH, McManus PM. A comparative review of melanocytic neoplasm. Vet Pathol 2002: 39: 651-78.
2. Rosengren Pielberg G, Golovko A, Sundström E et al. A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet 2008: 40: 1004-9.
3. Horin P, Cothran EG, Trtkova K et al. Polymorphism of Old Kladruby horses, a surviving but endangered baroque breed. Eur J Immunogenet 1998: 25: 57-63.
4. Seltenhammer MH, Simhofer H, Scherzer S et al. Equine melanoma in a population of 296 grey Lipizzaner horses. Equine Vet J 2003: 35: 153-7.
5. Ohnishi Y, Tajima S, Ishibashi A. Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells. Eur J Dermatol 2001: 11: 420-3.
6. Müller J, Feige K, Wunderlin P et al. Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DANN shows antitumor effect in metastatic melanoma in gray horses. J Immunother 2011: 34: 58-64.
7. Bogunovic D, Manches O, Godefroy E et al. TLR4 engagement during TLR3-induced pro-inflammatory signaling in dendritic cells promotes IL-10-mediated suppression of anti-tumor immunity. Cancer Res 2011: 71: 5467-76.