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Volumn 31, Issue 9, 2012, Pages 1189-1195

Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway

Author keywords

expanded; FRMD6; Hippo; LATS1; tumor suppressor; Willin

Indexed keywords

CYCLIN A; PACLITAXEL; PROTEIN HEX; PROTEIN LATS1; PROTEIN LATS2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84857784575     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.318     Document Type: Article
Times cited : (42)

References (37)
  • 1
    • 61749089153 scopus 로고    scopus 로고
    • The FERM-domain protein expanded regulates hippo pathway activity via direct interactions with the transcriptional activator yorkie
    • Badouel C, Gardano L, Amin N, Garg A, Rosenfeld R, Le Bihan T et al. (2009). The FERM-domain protein expanded regulates hippo pathway activity via direct interactions with the transcriptional activator yorkie. Dev Cell 16: 411-420.
    • (2009) Dev Cell , vol.16 , pp. 411-420
    • Badouel, C.1    Gardano, L.2    Amin, N.3    Garg, A.4    Rosenfeld, R.5    Le Bihan, T.6
  • 2
    • 0034177379 scopus 로고    scopus 로고
    • The drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development
    • Blaumueller CM, Mlodzik M. (2000). The drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development. Mech Dev 92: 251-262.
    • (2000) Mech Dev , vol.92 , pp. 251-262
    • Blaumueller, C.M.1    Mlodzik, M.2
  • 3
    • 0027291288 scopus 로고
    • Expanded: A gene involved in the control of cell proliferation in imaginal discs
    • Boedigheimer M, Laughon A. (1993). Expanded: a gene involved in the control of cell proliferation in imaginal discs. Development 118: 1291-1301.
    • (1993) Development , vol.118 , pp. 1291-1301
    • Boedigheimer, M.1    Laughon, A.2
  • 4
    • 0030972542 scopus 로고    scopus 로고
    • Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs
    • Boedigheimer MJ, Nguyen KP, Bryant PJ. (1997). Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs. Dev Genet 20: 103-110.
    • (1997) Dev Genet , vol.20 , pp. 103-110
    • Boedigheimer, M.J.1    Nguyen, K.P.2    Bryant, P.J.3
  • 6
    • 42349088170 scopus 로고    scopus 로고
    • A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
    • Chan SW, Lim CJ, Guo K, Ng CP, Lee I, Hunziker W et al. (2008). A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res 68: 2592-2598.
    • (2008) Cancer Res , vol.68 , pp. 2592-2598
    • Chan, S.W.1    Lim, C.J.2    Guo, K.3    Ng, C.P.4    Lee, I.5    Hunziker, W.6
  • 7
    • 38049103263 scopus 로고    scopus 로고
    • Fat and expanded act in parallel to regulate growth through warts
    • Feng Y, Irvine KD. (2007). Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci USA 104: 20362-20367.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20362-20367
    • Feng, Y.1    Irvine, K.D.2
  • 8
    • 76249093838 scopus 로고    scopus 로고
    • Kibra is a regulator of the Salvador/Warts/Hippo signaling network
    • Genevet A, Wehr MC, Brain R, Thompson BJ, Tapon N. (2010). Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell 18: 300-308.
    • (2010) Dev Cell , vol.18 , pp. 300-308
    • Genevet, A.1    Wehr, M.C.2    Brain, R.3    Thompson, B.J.4    Tapon, N.5
  • 10
    • 34047250808 scopus 로고    scopus 로고
    • RASSF1A is part of a complex similar to the drosophila Hippo/Salvador/Lats tumor-suppressor network
    • Guo C, Tommasi S, Liu L, Yee JK, Dammann R, Pfeifer GP. (2007). RASSF1A is part of a complex similar to the drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr Biol 17: 700-705.
    • (2007) Curr Biol , vol.17 , pp. 700-705
    • Guo, C.1    Tommasi, S.2    Liu, L.3    Yee, J.K.4    Dammann, R.5    Pfeifer, G.P.6
  • 11
    • 78650724753 scopus 로고    scopus 로고
    • Hippo signaling: Growth control and beyond
    • Halder G, Johnson RL. (2011). Hippo signaling: growth control and beyond. Development 138: 9-22.
    • (2011) Development , vol.138 , pp. 9-22
    • Halder, G.1    Johnson, R.L.2
  • 12
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and expanded act through hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C et al. (2006). The tumour-suppressor genes NF2/Merlin and expanded act through hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8: 27-36.
    • (2006) Nat Cell Biol , vol.8 , pp. 27-36
    • Hamaratoglu, F.1    Willecke, M.2    Kango-Singh, M.3    Nolo, R.4    Hyun, E.5    Tao, C.6
  • 13
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. (2011). Hallmarks of cancer: the next generation. Cell 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 14
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor LATS1 is a negative regulator of oncogene YAP
    • Hao Y, Chun A, Cheung K, Rashidi B, Yang X. (2008). Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 283: 5496-5509.
    • (2008) J Biol Chem , vol.283 , pp. 5496-5509
    • Hao, Y.1    Chun, A.2    Cheung, K.3    Rashidi, B.4    Yang, X.5
  • 15
    • 77951985216 scopus 로고    scopus 로고
    • Examination of the expanding pathways for the regulation of p21 expression and activity
    • Jung YS, Qian Y, Chen X. (2010). Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 22: 1003-1012.
    • (2010) Cell Signal , vol.22 , pp. 1003-1012
    • Jung, Y.S.1    Qian, Y.2    Chen, X.3
  • 16
    • 79953310106 scopus 로고    scopus 로고
    • Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF
    • Lai D, Ho KC, Hao Y, Yang X. (2011). Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res 71: 2728-2738.
    • (2011) Cancer Res , vol.71 , pp. 2728-2738
    • Lai, D.1    Ho, K.C.2    Hao, Y.3    Yang, X.4
  • 18
    • 41149098966 scopus 로고    scopus 로고
    • TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    • Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH et al. (2008). TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 28: 2426-2436.
    • (2008) Mol Cell Biol , vol.28 , pp. 2426-2436
    • Lei, Q.Y.1    Zhang, H.2    Zhao, B.3    Zha, Z.Y.4    Bai, F.5    Pei, X.H.6
  • 19
    • 79952759357 scopus 로고    scopus 로고
    • Identification of a tumor suppressor relay between the FOXP3 and the hippo pathways in breast and prostate cancers
    • Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. (2011). Identification of a tumor suppressor relay between the FOXP3 and the hippo pathways in breast and prostate cancers. Cancer Res 71: 2162-2171.
    • (2011) Cancer Res , vol.71 , pp. 2162-2171
    • Li, W.1    Wang, L.2    Katoh, H.3    Liu, R.4    Zheng, P.5    Liu, Y.6
  • 20
    • 0041302154 scopus 로고    scopus 로고
    • Lats2, a putative tumor suppressor, inhibits G1/S transition
    • Li Y, Pei J, Xia H, Ke H, Wang H, Tao W. (2003). Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene 22: 4398-4405.
    • (2003) Oncogene , vol.22 , pp. 4398-4405
    • Li, Y.1    Pei, J.2    Xia, H.3    Ke, H.4    Wang, H.5    Tao, W.6
  • 21
    • 0034033896 scopus 로고    scopus 로고
    • The neurofibromatosis-2 homologue, merlin, and the tumor suppressor expanded function together in drosophila to regulate cell proliferation and differentiation
    • McCartney BM, Kulikauskas RM, LaJeunesse DR, Fehon RG. (2000). The neurofibromatosis-2 homologue, merlin, and the tumor suppressor expanded function together in drosophila to regulate cell proliferation and differentiation. Development 127: 1315-1324.
    • (2000) Development , vol.127 , pp. 1315-1324
    • McCartney, B.M.1    Kulikauskas, R.M.2    Lajeunesse, D.R.3    Fehon, R.G.4
  • 23
    • 0030743399 scopus 로고    scopus 로고
    • WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases
    • Ogryzko VV, Wong P, Howard BH. (1997). WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol 17: 4877-4882.
    • (1997) Mol Cell Biol , vol.17 , pp. 4877-4882
    • Ogryzko, V.V.1    Wong, P.2    Howard, B.H.3
  • 24
    • 60849138138 scopus 로고    scopus 로고
    • Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of hippo signaling
    • Ota M, Sasaki H. (2008). Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of hippo signaling. Development 135: 4059-4069.
    • (2008) Development , vol.135 , pp. 4059-4069
    • Ota, M.1    Sasaki, H.2
  • 25
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan D. (2010). The hippo signaling pathway in development and cancer. Dev Cell 19: 491-505.
    • (2010) Dev Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 26
    • 33947105009 scopus 로고    scopus 로고
    • The drosophila tumor suppressors expanded and merlin differentially regulate cell cycle exit, apoptosis, and wingless signaling
    • Pellock BJ, Buff E, White K, Hariharan IK. (2007). The drosophila tumor suppressors expanded and merlin differentially regulate cell cycle exit, apoptosis, and wingless signaling. Dev Biol 304: 102-115.
    • (2007) Dev Biol , vol.304 , pp. 102-115
    • Pellock, B.J.1    Buff, E.2    White, K.3    Hariharan, I.K.4
  • 27
    • 33845426464 scopus 로고    scopus 로고
    • The drosophila RASSF homolog antagonizes the hippo pathway
    • Polesello C, Huelsmann S, Brown NH, Tapon N. (2006). The drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol 16: 2459-2465.
    • (2006) Curr Biol , vol.16 , pp. 2459-2465
    • Polesello, C.1    Huelsmann, S.2    Brown, N.H.3    Tapon, N.4
  • 28
    • 65649126416 scopus 로고    scopus 로고
    • The DeMSTification of mammalian Ste20 kinases
    • Radu M, Chernoff J. (2009). The DeMSTification of mammalian Ste20 kinases. Curr Biol 19: R421-R425.
    • (2009) Curr Biol , vol.19
    • Radu, M.1    Chernoff, J.2
  • 29
    • 12944293246 scopus 로고
    • The mutants of the extreme left end of the second chromosome of DROSOPHILA MELANOGASTER
    • Stern C, Bridges CB. (1926). The mutants of the extreme left end of the second chromosome of DROSOPHILA MELANOGASTER. Genetics 11: 503-530.
    • (1926) Genetics , vol.11 , pp. 503-530
    • Stern, C.1    Bridges, C.B.2
  • 30
    • 70350416086 scopus 로고    scopus 로고
    • Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray
    • Visser S, Yang X. (2010a). Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray. Gene 449: 22-29.
    • (2010) Gene , vol.449 , pp. 22-29
    • Visser, S.1    Yang, X.2
  • 31
    • 77958494807 scopus 로고    scopus 로고
    • LATS tumor suppressor: A new governor of cellular homeostasis
    • Visser S, Yang X. (2010b). LATS tumor suppressor: a new governor of cellular homeostasis. Cell Cycle 9: 3892-3903.
    • (2010) Cell Cycle , vol.9 , pp. 3892-3903
    • Visser, S.1    Yang, X.2
  • 32
    • 85047699404 scopus 로고    scopus 로고
    • LATS1 tumor suppressor regulates G2/M transition and apoptosis
    • Xia H, Qi H, Li Y, Pei J, Barton J, Blackstad M et al. (2002). LATS1 tumor suppressor regulates G2/M transition and apoptosis. Oncogene 21: 1233-1241.
    • (2002) Oncogene , vol.21 , pp. 1233-1241
    • Xia, H.1    Qi, H.2    Li, Y.3    Pei, J.4    Barton, J.5    Blackstad, M.6
  • 33
    • 79953150067 scopus 로고    scopus 로고
    • KIBRA regulates hippo signaling activity via interactions with large tumor suppressor kinases
    • Xiao L, Chen Y, Ji M, Dong J. (2011). KIBRA regulates hippo signaling activity via interactions with large tumor suppressor kinases. J Biol Chem 286: 7788-7796.
    • (2011) J Biol Chem , vol.286 , pp. 7788-7796
    • Xiao, L.1    Chen, Y.2    Ji, M.3    Dong, J.4
  • 34
    • 0035807242 scopus 로고    scopus 로고
    • Human homologue of drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis
    • Yang X, Li DM, Chen W, Xu T. (2001). Human homologue of drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis. Oncogene 20: 6516-6523.
    • (2001) Oncogene , vol.20 , pp. 6516-6523
    • Yang, X.1    Li, D.M.2    Chen, W.3    Xu, T.4
  • 35
    • 76249109900 scopus 로고    scopus 로고
    • Kibra functions as a tumor suppressor protein that regulates hippo signaling in conjunction with merlin and expanded
    • Yu J, Zheng Y, Dong J, Klusza S, Deng WM, Pan D. (2010). Kibra functions as a tumor suppressor protein that regulates hippo signaling in conjunction with merlin and expanded. Dev Cell 18: 288-299.
    • (2010) Dev Cell , vol.18 , pp. 288-299
    • Yu, J.1    Zheng, Y.2    Dong, J.3    Klusza, S.4    Deng, W.M.5    Pan, D.6
  • 36
    • 77951837150 scopus 로고    scopus 로고
    • The hippo-YAP pathway in organ size control and tumorigenesis: An updated version
    • Zhao B, Li L, Lei Q, Guan KL. (2010). The hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 24: 862-874.
    • (2010) Genes Dev , vol.24 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 37
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao B, Ye X, Yu J, Li L, Li W, Li S et al. (2008). TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 22: 1962-1971.
    • (2008) Genes Dev , vol.22 , pp. 1962-1971
    • Zhao, B.1    Ye, X.2    Yu, J.3    Li, L.4    Li, W.5    Li, S.6


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