Monitoring ibuprofen-nicotinamide cocrystal formation during solvent free continuous cocrystallization (SFCC) using near infrared spectroscopy as a PAT tool

International Journal of Pharmaceutics

Volumn 426, Issue 1-2, 2012, Pages 15-20

  Kelly, A L ^a   Gough, T ^a   Dhumal, R S ^a   Halsey, S A ^b   Paradkar, A ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b Thermo Fisher Scientific   (United States)

Author keywords

Cocrystals; Hot melt extrusion; Ibuprofen; Nicotinamide; NIR spectroscopy; PAT; Process analytics; QbD; Twin screw extrusion

Indexed keywords

IBUPROFEN; NICOTINAMIDE;

ARTICLE; COCRYSTAL; CRYSTAL; CRYSTALLIZATION; DRUG MIXTURE; HIGH TEMPERATURE; NEAR INFRARED SPECTROSCOPY; PRIORITY JOURNAL; PROCESSING; QUALITY CONTROL; SOLVENT FREE CONTINUOUS COCRYSTALLIZATION; TWIN SCREW EXTRUSION; X RAY DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG COMPOUNDING; IBUPROFEN; LEAST-SQUARES ANALYSIS; NIACINAMIDE; POWDER DIFFRACTION; SOLVENTS; SPECTROSCOPY, NEAR-INFRARED; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS;

EID: 84857784349     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.12.033     Document Type: Article

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