메뉴 건너뛰기




Volumn 8, Issue 1, 2012, Pages 26-33

In silico, in vitro and in vivo assessment of safety and anti-inflammatory activity of curcumin

Author keywords

Anti inflammatory activity; Docking studies; Dosage required; Immunologic release; Inflammatory mediators; Multi target potency; Paw edema; Protein kinase; Safety profile; Though curcumin

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CARRAGEENAN; CHEMOKINE; CURCUMIN; CYTOKINE; HISTAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; LIPOXYGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

EID: 84857773187     PISSN: 15536203     EISSN: None     Source Type: Journal    
DOI: 10.3844/ajidsp.2012.26.33     Document Type: Article
Times cited : (34)

References (27)
  • 1
    • 0032858660 scopus 로고    scopus 로고
    • Effect of loratadine on nitrogen dioxide-induced changes in electrical resistance and release of inflammatory mediators from cultured human bronchial epithelial cells
    • Bayram, H., J.L. Devalia, O.A. Khair, M.M. Abdelaziz and R.J. Sapsford et al., 1999. Effect of loratadine on nitrogen dioxide-induced changes in electrical resistance and release of inflammatory mediators from cultured human bronchial epithelial cells. J. Allergy, Clin. Immunol., 104: 93-99.
    • (1999) J. Allergy, Clin. Immunol , vol.104 , pp. 93-99
    • Bayram, H.1    Devalia, J.L.2    Khair, O.A.3    Abdelaziz, M.M.4    Sapsford, R.J.5
  • 2
    • 38849166772 scopus 로고    scopus 로고
    • Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-κB and ERK signalling
    • DOI: 10.1038/sj.bjp.0707542
    • Chen, A. and S. Zheng, 2008. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-κB and ERK signalling. British J. Pharmacol., 153: 557-567. DOI: 10.1038/sj.bjp.0707542
    • (2008) British J. Pharmacol , vol.153 , pp. 557-567
    • Chen, A.1    Zheng, S.2
  • 3
    • 33947532054 scopus 로고    scopus 로고
    • Curcumin attenuates the expression of IL-1ß, IL-6 and TNF-· as well as cyclin E in TNF-· -treated HaCaT cells; NF-κB and MAPKs as potential upstream targets
    • PMID: 17273796
    • Cho, J.W., K.S. Lee and C.W. Kim, 2007. Curcumin attenuates the expression of IL-1ß, IL-6 and TNF-· as well as cyclin E in TNF-· -treated HaCaT cells; NF-κB and MAPKs as potential upstream targets. Int. J. Mol. Med., 19: 469-474. PMID: 17273796
    • (2007) Int. J. Mol. Med , vol.19 , pp. 469-474
    • Cho, J.W.1    Lee, K.S.2    Kim, C.W.3
  • 4
    • 0141814600 scopus 로고    scopus 로고
    • Curcumin inhibits phorbol esterinduced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signalregulated kinase activity and NF-kB activation
    • PMID: 12844482
    • Chun, K.S., Y.S. Keum, S.S. Han, Y.S. Song and S.H. Kim et al., 2003. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signalregulated kinase activity and NF-kB activation. Carcinogenesis, 24: 1515-1524. PMID: 12844482
    • (2003) Carcinogenesis , vol.24 , pp. 1515-1524
    • Chun, K.S.1    Keum, Y.S.2    Han, S.S.3    Song, Y.S.4    Kim, S.H.5
  • 5
    • 77950363955 scopus 로고    scopus 로고
    • Curcumin suppresses p38 mitogen-activated protein kinase activation, reducesIL-1b and matrix metalloproteinase-3 and enhances IL-10 in the mucosa ofchildren and adults with inflammatory bowel disease
    • DOI:10.1017/S0007114509992510
    • Epstein, J., G. Docena, T.T. MacDonald and I.R. Sanderson, 2010. Curcumin suppresses p38 mitogen-activated protein kinase activation, reducesIL-1b and matrix metalloproteinase-3 and enhances IL-10 in the mucosa ofchildren and adults with inflammatory bowel disease. Br. J. Nutr., 103: 824-832. DOI:10.1017/S0007114509992510
    • (2010) Br. J. Nutr , vol.103 , pp. 824-832
    • Epstein, J.1    Docena, G.2    Macdonald, T.T.3    Sanderson, I.R.4
  • 6
    • 0037089574 scopus 로고    scopus 로고
    • Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice
    • DOI: 10.1084/jem.20011782
    • Ghosh, A.K., N. Hirasawa, H. Ohtsu, T. Watanabe and K. Ohuchi, 2002. Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice. J. Exp. Med., 195: 973-982. DOI: 10.1084/jem.20011782
    • (2002) J. Exp. Med , vol.195 , pp. 973-982
    • Ghosh, A.K.1    Hirasawa, N.2    Ohtsu, H.3    Watanabe, T.4    Ohuchi, K.5
  • 7
    • 44749093175 scopus 로고    scopus 로고
    • Curcumin: From ancient medicine to current clinical trials
    • DOI: 10.1007/s00018-008-7452-4
    • Hatcher, H., R. Planalp, J. Cho, F.M. Torti and S.V. Torti, 2008. Curcumin: From ancient medicine to current clinical trials. Rev. Cell. Mol. Life Sci., 65: 1631-1652. DOI: 10.1007/s00018-008-7452-4
    • (2008) Rev. Cell. Mol. Life Sci , vol.65 , pp. 1631-1652
    • Hatcher, H.1    Planalp, R.2    Cho, J.3    Torti, F.M.4    Torti, S.V.5
  • 8
    • 0026029402 scopus 로고
    • Inhibitory Effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse Epidermis
    • Huang, M.T., T. Lysz, T. Ferrara, T.F. Abidi and J.D. Laskin et al., 1991. Inhibitory Effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse Epidermis. Cancer Res., 51: 813-819.
    • (1991) Cancer Res , vol.51 , pp. 813-819
    • Huang, M.T.1    Lysz, T.2    Ferrara, T.3    Abidi, T.F.4    Laskin, J.D.5
  • 9
    • 0028070733 scopus 로고
    • Histamine induces interleukin-8 secretion by endothelial cells
    • Jeannin, P., Y. Delneste, P. Gosset, S. Molet and P. Lassalle et al., 1994. Histamine induces interleukin-8 secretion by endothelial cells. Blood, 84: 2229-33.
    • (1994) Blood , vol.84 , pp. 2229-2233
    • Jeannin, P.1    Delneste, Y.2    Gosset, P.3    Molet, S.4    Lassalle, P.5
  • 10
    • 0014819737 scopus 로고
    • N-Acetyl- β-glucosaminidase in rat mast cell granules
    • DOI: 10.1016/0014-4827(70)90265-X
    • Lagunoff, D., P. Pritzl and L. Mueller, 1970. N-Acetyl- β-glucosaminidase in rat mast cell granules. Exp. Cell Res. 61: 129-132. DOI: 10.1016/0014- 4827(70)90265-X
    • (1970) Exp. Cell Res , vol.61 , pp. 129-132
    • Lagunoff, D.1    Pritzl, P.2    Mueller, L.3
  • 11
    • 0015509523 scopus 로고
    • The mechanism of histamine release from mast cells
    • DOI: 10.1016/0006-2952(72)90001-9
    • Lagunoff, D., 1972. The mechanism of histamine release from mast cells. Biochem. Pharmacol., 21: 1893-1896. DOI: 10.1016/0006-2952(72)90001-9
    • (1972) Biochem. Pharmacol , vol.21 , pp. 1893-1896
    • Lagunoff, D.1
  • 12
    • 0027173480 scopus 로고
    • Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells
    • DOI:10.1093/carcin/14.5.857
    • Liu, J.Y., S.J. Lin and J.K. Lin, 1993. Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells. Carcinogenesis, 14: 857-861. DOI:10.1093/carcin/14.5.857
    • (1993) Carcinogenesis , vol.14 , pp. 857-861
    • Liu, J.Y.1    Lin, S.J.2    Lin, J.K.3
  • 13
    • 0018121081 scopus 로고
    • Release of arylsulfatase A but not B from rat mast cells by noncytolytic secretory stimuli
    • PMID: 81231
    • Lynch, S.M., K.F. Austen and S.I. Wasserman, 1978. Release of arylsulfatase A but not B from rat mast cells by noncytolytic secretory stimuli. J. Immunol., 121: 1394-1399. PMID: 81231
    • (1978) J. Immunol , vol.121 , pp. 1394-1399
    • Lynch, S.M.1    Austen, K.F.2    Wasserman, S.I.3
  • 14
    • 84934436057 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory properties of curcumin
    • PMID: 17569207
    • Menon, V.P. and A.R. Sudheer, 2007. Antioxidant and anti-inflammatory properties of curcumin. Adv. Exp. Med. Biol. 595: 105-25. PMID: 17569207
    • (2007) Adv. Exp. Med. Biol , vol.595 , pp. 105-125
    • Menon, V.P.1    Sudheer, A.R.2
  • 15
    • 0026165184 scopus 로고
    • Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines
    • DOI: 10.1007/BF01993163
    • Meretey, K., A. Falus, T. Taga and T. Kishimoto, 1991. Histamine influences the expression of the interleukin-6 receptor on human lymphoid, monocytoid and hepatoma cell lines. Agents Actions, 33: 189-191. DOI: 10.1007/BF01993163
    • (1991) Agents Actions , vol.33 , pp. 189-191
    • Meretey, K.1    Falus, A.2    Taga, T.3    Kishimoto, T.4
  • 16
    • 0027532883 scopus 로고
    • Ca2+- dependent and Ca2+-independent isozymes of protein kinase C mediate exocytosis in antigenstimulated Rat Basophilic RBL-2H3 Cells
    • Ozawa, K., Z. Szallasie, M.G. Kazanietzs, P.M. Blumberg and H. Mischak et al., 1993. Ca2+- dependent and Ca2+-independent isozymes of protein kinase C mediate exocytosis in antigenstimulated Rat Basophilic RBL-2H3 Cells. J. Biol. Chem. 268: 1749-1756.
    • (1993) J. Biol. Chem , vol.268 , pp. 1749-1756
    • Ozawa, K.1    Szallasie, Z.2    Kazanietzs, M.G.3    Blumberg, P.M.4    Mischak, H.5
  • 17
    • 0033208795 scopus 로고    scopus 로고
    • Histamine induced homologous and heterologous regulation of histamine receptor subtype mRNA expression in cultured endothelial cells
    • Schaefer, U., V. Schmitz, A. Schneider and E. Neugebauer, 1999. Histamine induced homologous and heterologous regulation of histamine receptor subtype mRNA expression in cultured endothelial cells. Shock, 12: 309-315.
    • (1999) Shock , vol.12 , pp. 309-315
    • Schaefer, U.1    Schmitz, V.2    Schneider, A.3    Neugebauer, E.4
  • 18
    • 0018715705 scopus 로고
    • Immunologic release of β-hexosaminidase and β-glucuronidase from purified rat serosal mast cells
    • Schwartz, L.B., K.F. Austen and S.I. Wasserman, 1979. Immunologic release of β-hexosaminidase and β-glucuronidase from purified rat serosal mast cells. J. Immunol., 123: 1445-1450.
    • (1979) J. Immunol , vol.123 , pp. 1445-1450
    • Schwartz, L.B.1    Austen, K.F.2    Wasserman, S.I.3
  • 19
    • 0018959390 scopus 로고
    • Enzymes of the mast cell granule
    • DOI:10.1111/1523-1747.ep12543620
    • Schwartz, L.B. and K.F. Austen, 1980. Enzymes of the mast cell granule. J. Invest. Dermatol., 74: 349-353. DOI:10.1111/1523-1747.ep12543620
    • (1980) J. Invest. Dermatol , vol.74 , pp. 349-353
    • Schwartz, L.B.1    Austen, K.F.2
  • 20
    • 0034321972 scopus 로고    scopus 로고
    • Curcumin inhibits lipoxygenase by binding to its central cavity: Theoretical and X-ray evidence
    • Skrzyczak-Jankun, E., N.P. McCabe, S.H. Selman and J. Jankun, 2000. Curcumin inhibits lipoxygenase by binding to its central cavity: Theoretical and X-ray evidence. Int. J. Mol. Med., 6: 521-526.
    • (2000) Int. J. Mol. Med , vol.6 , pp. 521-526
    • Skrzyczak-Jankun, E.1    McCabe, N.P.2    Selman, S.H.3    Jankun, J.4
  • 21
    • 0347953622 scopus 로고    scopus 로고
    • Structure of curcumin in complex with lipoxygenase and its significance in cancer
    • Skrzyczak-Jankun, E., K. Zhou, N.P. McCabe, H. Selman and J. Jankun, 2003. Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int. J. Mol. Med., 12: 17-24.
    • (2003) Int. J. Mol. Med , vol.12 , pp. 17-24
    • Skrzyczak-Jankun, E.1    Zhou, K.2    McCabe, N.P.3    Selman, H.4    Jankun, J.5
  • 22
    • 77953240038 scopus 로고    scopus 로고
    • Hepatotoxicity due to histamine trifluoro-methyl toluidide, amthamine, R-(-)-α-Methyl histamine and clobenpropit (H1RH4R-Agonists, Respectively) in rabbit experimental model
    • DOI:10.3844/amjsp.2010.1.17
    • Tripathi, T., A.A. Khan, M. Shahid, H.M. Khan and M. Siddiqui et al., 2010. Hepatotoxicity due to histamine trifluoro-methyl toluidide, amthamine, R-(-)-α-Methyl histamine and clobenpropit (H1RH4R-Agonists, Respectively) in rabbit experimental model. Am. Med. J., 1: 1-7. DOI:10.3844/amjsp.2010.1.17
    • (2010) Am. Med. J , vol.1 , pp. 1-7
    • Tripathi, T.1    Khan, A.A.2    Shahid, M.3    Khan, H.M.4    Siddiqui, M.5
  • 23
    • 79960213002 scopus 로고    scopus 로고
    • Influence of dietary curcumin on rumen fermentation, macronutrient digestion and nitrogen balance in beef cattle
    • DOI: 10.3844/ajabssp.2011.7.11
    • Vorlaphim, T., M. Phonvisay, J. Khotsakdee, K. Vasupen and S. Bureenok et al., 2011. Influence of dietary curcumin on rumen fermentation, macronutrient digestion and nitrogen balance in beef cattle. Am. J. Agric. Biol. Sci., 6: 7-11. DOI: 10.3844/ajabssp.2011.7.11
    • (2011) Am. J. Agric. Biol. Sci , vol.6 , pp. 7-11
    • Vorlaphim, T.1    Phonvisay, M.2    Khotsakdee, J.3    Vasupen, K.4    Bureenok, S.5
  • 24
    • 0027257155 scopus 로고
    • Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist
    • DOI: 10.1172/JCI116562
    • Vannier, E. and C.A. Dinarello, 1993. Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist. J. Clin. Invest., 92: 281-287. DOI: 10.1172/JCI116562
    • (1993) J. Clin. Invest , vol.92 , pp. 281-287
    • Vannier, E.1    Dinarello, C.A.2
  • 25
    • 24044532589 scopus 로고    scopus 로고
    • Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells
    • PMID: 16102725
    • Woo, M., S. Jung, S. Kim, J. Hyun and K. Ko, et al., 2005. Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem. Bioph. Res. Commun., 335: 1017-1025. PMID: 16102725
    • (2005) Biochem. Bioph. Res. Commun , vol.335 , pp. 1017-1025
    • Woo, M.1    Jung, S.2    Kim, S.3    Hyun, J.4    Ko, K.5
  • 26
    • 0031439994 scopus 로고    scopus 로고
    • Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells
    • PMID: 9439980
    • Xu, Y.X., K.R. Pindolia, N. Janakiraman, R.A. Chapman and S.C. Gautam, 1998. Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells. Hematopathol. Mol. Hematol., 11: 49-62. PMID: 9439980
    • (1998) Hematopathol. Mol. Hematol , vol.11 , pp. 49-62
    • Xu, Y.X.1    Pindolia, K.R.2    Janakiraman, N.3    Chapman, R.A.4    Gautam, S.C.5
  • 27
    • 19644367000 scopus 로고    scopus 로고
    • Activation and signaling of the p38 MAP kinase pathway
    • DOI:10.1038/sj.cr.7290257
    • Zarubin, T. and J. Han, 2005. Activation and signaling of the p38 MAP kinase pathway. Cell Res., 15: 11-18. DOI:10.1038/sj.cr.7290257
    • (2005) Cell Res , vol.15 , pp. 11-18
    • Zarubin, T.1    Han, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.