Nicotinic acid induces antinociceptive and anti-inflammatory effects in different experimental models

Pharmacology Biochemistry and Behavior

Volumn 101, Issue 3, 2012, Pages 493-498

  Godin, Adriana M ^a   Ferreira, Wallace C ^a   Rocha, Leonardo Tadeu S ^a   Ferreira, Raphael G ^a   Paiva, André Luiz L ^a   Merlo, Leonardo A ^a   Nascimento Jr , Elias B ^a   Bastos, Leandro Francisco S ^a   Coelho, Márcio M ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Inflammation; Isonicotinic acid; Nicotinic acid; Nociception; Pain; Picolinic acid

Indexed keywords

CARRAGEENAN; DEXAMETHASONE; DIPYRONE; FORMALDEHYDE; ISONICOTINIC ACID; NICOTINIC ACID; PHENOBARBITAL; PICOLINIC ACID;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG HALF LIFE; DRUG INHIBITION; FEMALE; GROWTH INHIBITION; HOT PLATE TEST; INFLAMMATION; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PAIN THRESHOLD; PAW EDEMA; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DISEASE MODELS, ANIMAL; EDEMA; FEMALE; HUMANS; HYPERALGESIA; MICE; MOTOR ACTIVITY; NIACIN; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR;

MUS; RATTUS;

EID: 84857766113     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.02.012     Document Type: Article

References (52)

1. Altschul R, Hoffer A, Stephen JD. Influence of nicotinic acid on serum cholesterol in man. Arch Biochem 1955;54:558-9.
2. Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 2004;3:673-83. (Pubitemid 39173508)
3. Barsante MM, Roffê E, Yokoro CM, TafuriWL, Souza DG, Pinho V, et al. Anti-inflammatory and analgesic effects of atorvastatin in a ratmodel of adjuvant-induced arthritis. Eur J Pharmacol 2005;516:282-9. (Pubitemid 40922750)
4. Bleakman D, Alt A, Nisenbaum ES. Glutamate receptors and pain. Semin Cell Dev Biol 2006;17:592-604. (Pubitemid 46389351)
5. Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: amolecular evaluation of NAD+precursor vitamins in human nutrition. Annu Rev Nutr 2008;28:115-30.
6. Carlson LA. Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. J Intern Med 2005;258:94-114. (Pubitemid 41025967)
7. Chen YL, Le Vraux V, Giroud JP, Chauvelot-Moachon L. Anti-tumor necrosis factor properties of non-peptide drugs in acute-phase responses. Eur J Pharmacol 1994;271:319-27.
8. Chichorro JG, Lorenzetti BB, Zampronio AR. Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats. Br J Pharmacol 2004;141:1175-84. (Pubitemid 38582255)
9. Collins PB, Chaykin S. The management of nicotinamide and nicotinic acid in the mouse. J Biol Chem 1972;247:778-83.
10. Crowley CL, Payne CM, Bernstein H, Bernstein C, Roe D. The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate. Cell Death Differ 2000;7:314-26. (Pubitemid 30192980)
11. Cunha JM, Cunha FQ, Poole S, Ferreira SH. Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist. Br J Pharmacol 2000;130:1418-24. (Pubitemid 30488609)
12. Digby JE, McNeill E, Dyar OJ, Lam V, Greaves DR, Choudhury RP. Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin. Atherosclerosis 2010;209: 89-95.
13. Fu ES, Zhang YP, Sagen J, Yang ZQ, Bethea JR. Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice. Neuroreport 2007;18:713-7. (Pubitemid 46608521)
14. Ganji SH, Qin S, Zhang L, Kamanna VS, Kashyap ML. Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis 2009;202:68-75.
15. Garcia GG, Miranda HF, Noriega V, Sierralta F, Olavarria L, Zepeda RJ, et al. Antinociception induced by atorvastatin in different pain models. Pharmacol Biochem Behav 2011;100:125-9.
16. Gaskill BN, Rohr SA, Pajor EA, Lucas JR, Garner JP. Some like it hot: mouse temperature preferences in laboratory housing. Appl Anim Behav Sci 2009;116:279-85.
17. Godin AM, Ferreira WC, Rocha LT, Seniuk JG, Paiva AL, Merlo LA, et al. Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models. Pharmacol Biochem Behav 2011;99:782-8.
18. Gordon CJ. Thermal biology of the laboratory rat. Physiol Behav 1990;47:963-91. (Pubitemid 20171701)
19. Handy RL, Moore PK. A comparison of the effects of L-NAME, 7-NI and L-NIL on Carrageenan-induced hindpaw oedema and NOS activity. Br J Pharmacol 1998;123: 1119-26. (Pubitemid 28120509)
20. Heyliger SO, Goodman CB, Ngong JM, Soliman KF. The analgesic effects of tryptophan and its metabolites in the rat. Pharmacol Res 1998;38:243-50. (Pubitemid 28466743)
21. Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987;30:103-14. (Pubitemid 17094194)
22. Ijichi H, Ichiyama A, Hayaishi O. Studies on the biosynthesis of nicotinamide adenine dinucleotide. 3. Comparative in vivo studies on nicotinic acid, nicotinamide, and quinolinic acid as precursors of nicotinamide adenine dinucleotide. J Biol Chem 1966;241:3701-7.
23. Knowles HJ, te Poele RH, Workman P, Harris AL. Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochem Pharmacol 2006;71:646-56. (Pubitemid 43121998)
24. Kostylina G, Simon D, Fey MF, Yousefi S, Simon HU. Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A). Cell Death Differ 2008;15:134-42. (Pubitemid 350286181)
25. Kwon WY, Suh GJ, Kim KS, Kwak YH. Niacin attenuates lung inflammation and improves survival during sepsis by downregulating the nuclear factor-kappaB pathway. Crit Care Med 2011;39:328-34.
26. Lapin IP. Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol- induced seizures. Pharmacol Biochem Behav 1981;14:589-93. (Pubitemid 11123313)
27. Larsson M. Ionotropic glutamate receptors in spinal nociceptive processing. Mol Neurobiol 2009;40:260-88.
28. Lawrence T. The nuclear factor NF-κB pathway in inflammation. Cold Spring Harb Perspect Biol 2009;1a001651.
29. Lentsch AB,Ward PA. Activation and regulation of NFkappaB during acute inflammation. Clin Chem Lab Med 1999;37:205-8. (Pubitemid 29209731)
30. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, et al. TRPA1mediates formalin-induced pain. Proc Natl Acad Sci U S A 2007;104:13525-30.
31. Nakamura A, Fujita M, Shiomi H. Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia. Br J Pharmacol 1996;117:407-12. (Pubitemid 26056851)
32. Niederberger E, Schmidtko A, Gao W, Kühlein H, Ehnert C, Geisslinger G. Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-[kappa]B. Eur J Pharmacol 2007;559:55-60. (Pubitemid 46274646)
33. Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, AP IJ. International union of basic and clinical pharmacology. LXXXII: nomenclature and classification of hydroxy-carboxylic acid receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev 2011;63:269-90.
34. Oliveira ACP, Bertollo CM, Rocha LTS, Nascimento JEB, Costa KA, Coelho MM. Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma. Eur J Pharmacol 2007;561:194-201. (Pubitemid 46435842)
35. Petrack B, Greengard P, Kalinsky H. On the relative efficacy of nicotinamide and nicotinic acid as precursors of nicotinamide adenine dinucleotide. J Biol Chem 1966;241:2367-72.
36. Pollak N, Dolle C, Ziegler M. The power to reduce: pyridine nucleotides-small molecules with a multitude of functions. Biochem J 2007;402:205-18. (Pubitemid 46383418)
37. Salvemini D, Wang ZQ, Wyatt PS, Bourdon DM, Marino MH, Manning PT, et al. Nitric oxide: a key mediator in the early and late phase of Carrageenan-induced rat paw inflammation. Br J Pharmacol 1996;118:829-38. (Pubitemid 26261251)
38. Seliger J, Zagar V, Zidansek A, Blinc R. 14N nuclear quadrupole resonance of picolinic, nicotinic, isonicotinic and dinicotinic acids. Chem Phys 2006;331:131-6.
39. Souza AL, Moreira FA, Almeida KR, Bertollo CM, Costa KA, Coelho MM. In vivo evidence for a role of protein kinase C in peripheral nociceptive processing. Br J Pharmacol 2002;135:239-47. (Pubitemid 34102118)
40. Sum Z, Anderson R. NF-κB activation and inhibition: a review. Shock 2002;18:99-106.
41. Tavintharan S, Lim SC, Sum CF. Effects of niacin on cell adhesion and early atherogenesis: biochemical and functional findings in endothelial cells. Basic Clin Pharmacol Toxicol 2009;104:206-10.
42. Tavintharan S, Woon K, Pek LT, Jauhar N, Dong X, Lim SC, et al. Niacin results in reduced monocyte adhesion in patients with type 2 diabetes mellitus. Atherosclerosis 2011;215:176-9.
43. Tian LJ, Du YR, Xiao Y, Lv ZM, Yu YQ, Cui XY, et al.Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde. Sheng Li Xue Bao 2009;61:404-16.
44. Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992;51:5-17.
45. Tonohiro T, TanabeM, Kaneko T, Iwata N. Is picolinic acid a glycine agonist at strychnine-sensitive receptors? Brain Res 1990;516:332-4. (Pubitemid 20185564)
46. Tonussi CR, Ferreira SH. Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur J Pharmacol 1994;251:173-9. (Pubitemid 24061092)
47. Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, et al. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 2003;9:352-5. (Pubitemid 36362793)
48. Vinegar R, Truax JF, Selph JL, Johnston PR, Venable AL, McKenzie KK. Pathway to Carrageenan-induced inflammation in the hind limb of the rat. Fed Proc 1987;46:118-26.
49. Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 2011;70:482-94.
50. Wang QJ, Giri SN, Hyde DM, Nakashima JM, Javadi I. Niacin attenuates bleomycininduced lung fibrosis in the hamster. J Biochem Toxicol 1990;5:13-22.
51. Wierzbicki AS. Niacin: the only vitamin that reduces cardiovascular events. Int J Clin Pract 2011;65:379-85.
52. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10. (Pubitemid 13058546)