Dengue-3 encephalitis promotes anxiety-like behavior in mice

Behavioural Brain Research

Volumn 230, Issue 1, 2012, Pages 237-242

  de Miranda, Aline Silva ^a   Rodrigues, David Henrique ^a   Amaral, Débora Cristina Guerra ^a   de Lima Campos, Roberta Dayrell ^a   Cisalpino, Daniel ^a   Vilela, Márcia Carvalho ^a   Lacerda Queiroz, Norinne ^a   de Souza, Kátia Paulino Ribeiro ^a   Vago, Juliana Priscila ^a   Campos, Marco Antônio ^b   Kroon, Erna Geesien ^a   da Glória de Souza, Danielle ^a   Teixeira, Mauro Martins ^a   Teixeira, Antônio Lúcio ^a   Rachid, Milene Alvarenga ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Anxiety like behavior; Elevated plus maze; Hippocampus; Inflammation; Non adapted DENV 3

Indexed keywords

BRAIN PROTEIN; CASPASE 3; CYTOKINE; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; APOPTOSIS; ARTICLE; BRAIN LEVEL; BRAIN NERVE CELL; CELL INFILTRATION; CELL LOSS; CONTROLLED STUDY; DENGUE VIRUS 3; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; INOCULATION; LOCOMOTION; MALE; MAZE TEST; MENINGOENCEPHALITIS; MOTOR ACTIVITY; MOUSE; NONHUMAN; OPEN FIELD TEST; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VIRUS ENCEPHALITIS; VIRUS ISOLATION;

ANIMALS; ANXIETY DISORDERS; APOPTOSIS; DENGUE; DENGUE VIRUS; DISEASE MODELS, ANIMAL; ENCEPHALITIS; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; INTERLEUKIN-6; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; VIRAL PROTEINS;

EID: 84857756717     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.02.020     Document Type: Article

References (31)

1. Mackenzie J.S., Gubler D.J., Petersen L.R. Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses. Nat Med 2004, 10:S98-S109.
2. World Health Organization Impact of dengue 2009, http://www.who.int/csr/disease/dengue/en/.
3. Soares C.N., Cabral-Castro M.J., Peralta J.M., Freitas M.R.G., Zalis M., Puccioni-Sohler M. Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. J Neurol Sci 2011, 303:75-79.
4. Varatharaj A. Encephalitis in the clinical spectrum of dengue infection. Neurol India 2010, 58:585-591.
5. Solomon T., Dung N.M., Vaughn D.W., Kneen R., Thao L.T., Raengsakulrach B., et al. Neurological manifestations of dengue infection. Lancet 2000, 25:1053-1059.
6. Domingues R.B., Kuster G.W., Onuki-Castro F.L., Souza V.A., Levi J.E., Pannuti C.S. Involvement of the central nervous system in patients with dengue virus infection. J Neurol Sci 2008, 267:36-40.
7. Amaral D.C., Rachid M.A., Vilela M.C., Campos R.D., Ferreira G.P., Rodrigues D.H., et al. Intracerebral infection with dengue-3 virus induces meningoencephalitis and behavioral changes that precede lethality in mice. J Neuroinflammation 2011, 8. 10.1186/1742-2094-8-23.
8. Pinto L.M., Oliveira S.A., Braga E.L., Nogueira R.M., Kubelka C.F. Increased pro-inflammatory cytokines (TNF-alpha and IL-6) and anti-inflammatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever. Mem Inst Oswaldo Cruz 1999, 94:387-394.
9. O'Donovan A., Hughes B.M., Slavich G.M., Lynch L., Cronin M.T., O'Farrelly C., et al. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships. Brain Behav Immun 2010, 24:1074-1077.
10. Connor J., Song C., Leonard B.E., Merali Z., Anisman H. An assessment of the effects of central interleukin-1beta, -2, -6, and tumor necrosis factor-alpha administration on some behavioural, neurochemical, endocrine and immune parameters in the rat. Neuroscience 1998, 84:923-933.
11. Anisman H., Merali Z. Anhedonic and anxiogenic effects of cytokine exposure. Adv Exp Med Biol 1999, 461:199-233.
12. Figueiredo B.L., Cecílio A.B., Portela F.G., Drumond P.B., Oliveira G.J., Bonjardim C.A., et al. Dengue virus 3 genotype 1 associated with dengue fever and dengue hemorrhagic fever, Brazil. Emerg Infect Dis 2008, 14:314-316.
13. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 1987, 92:180-185.
14. Pellow S., Chopin P., File S.E., Briley M. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985, 14:149-167.
15. File S.E. Factors controlling measures of anxiety and responses to novelty in the mouse. Behav Brain Res 2001, 125:151-157.
16. Walf A.A., Frye C.A. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc 2007, 2:322-328.
17. Barichello T., Santos I., Savi G.D., Simões L.R., Generoso J.S., Comim C.M., et al. Depressive-like-behavior and proinflamatory interleukin levels in the brain of rats submitted to pneumococcal meningitis. Brain Res Bull 2010, 82:243-246.
18. Freeman-Daniels E., Beck S.G., Kirby L.G. Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT(1A) receptor knockout mice. Psychopharmacology 2011, 213:453-463. 10.1007/s00213-010-2030-5.
19. Peruga I., Hartwig S., Thöne J., Hovemann B., Gold R., Juckel G., et al. Inflammation modulates anxiety in an animal model of multiple sclerosis. Behav Brain Res 2011, 220:20-29.
20. Misra U.K., Kalita J., Syam U.K., Dhole T.N. Neurological manifestations of dengue virus infection. J Neurol Sci 2006, 244:117-122.
21. Miranda A.S., Lacerda-Queiroz N., Vilela M.C., Rodrigues D.H., Rachid M.A., Quevedo J., et al. Anxiety-like behavior and proinflammatory cytokine levels in the brain of C57BL/6 mice infected with Plasmodium berghei (strain ANKA). Neurosci Lett 2011, 491(3):202-206.
22. Skurlova M., Stofkova A., Jurcovicova J. Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β: IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats. Neurosci Lett 2010, 487(2):250-254.
23. Lacosta S., Merali Z., Anisman H. Behavioral and neurochemical consequences of lipopolysaccharide in mice: anxiogenic-like effects. Brain Res 1999, 818:291-303.
24. Swiergiel A.H., Dunn A.J. Effects of interleukin-1β and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests. Pharmacol Biochem Behav 2007, 86:651-659.
25. Samuel M.A., Diamond M.S. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol 2005, 79:13350-13361.
26. Buenz E.J., Sauer B.M., Lafrance-Corey R.G., Deb C., Denic A., German C.L., et al. Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infection. Am J Pathol 2009, 175(2):668-684.
27. Bergmann C.C., Parra B., Hinton D.R., Ramakrishna C., Dowdell K.C., Stohlman S.A. Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8T cells in the absence of CD4T cells. J Virol 2004, 78:1739-1750.
28. Phares T.W., Stohlman S.A., Hinton D.R., Atkinson R., Bergmann C.C. Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. J Immunol 2010, 185(9):5607-5618.
29. Desprès P., Frenkiel M.P., Ceccaldi P.E., Santos C.D., Deubel V. Apoptosis in the mouse central nervous system in response to infection with mouse-neurovirulent dengue viruses. J Virol 1998, 72(1):823-829.
30. Sánchez-Burgos G., Hernández-Pando R., Campbell I.L., Ramos-Castañeda J., Ramos C. Cytokine production in brain of mice experimentally infected with dengue virus. Neuroreport 2004, 15(1):37-42.
31. Yeo P.S., Pinheiro L., Tong P., Lim P.L., Sitoh Y.Y. Hippocampal involvement in dengue fever. Singapore Med J 2005, 46(11):647-650.