The thrombin inhibitors hirudin and Refludan® activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets

Thrombosis and Haemostasis

Volumn 107, Issue 3, 2012, Pages 521-529

  Kobsar, Anna ^a   Koessler, Juergen ^a   Kehrer, Linda ^a   Gambaryan, Stepan ^a,b   Walter, Ulrich ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

cGMP pathway; Hirudin; Lepirudin; PKG; PRI; sGC; VASP

Indexed keywords

CYCLIC AMP; CYCLIC GMP; GUANYLATE CYCLASE; HIRUDIN; LEPIRUDIN; PADGEM PROTEIN; PROSTAGLANDIN E1; PROTEIN KINASE; THROMBIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ADULT; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; PLATELET REACTIVITY INDEX; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE FUNCTION; WESTERN BLOTTING;

ADULT; BLOOD PLATELETS; BLOOD SPECIMEN COLLECTION; CELL ADHESION MOLECULES; CYCLIC AMP; CYCLIC GMP; ENZYME ACTIVATION; FEMALE; FIBRINOLYTIC AGENTS; GUANYLATE CYCLASE; HIRUDINS; HUMANS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET FUNCTION TESTS; RECOMBINANT PROTEINS; REFERENCE STANDARDS; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84857743572     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH11-07-0461     Document Type: Article

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