Identification of the neogenin-binding site on the repulsive guidance molecule A

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Itokazu, Takahide ^a,b,c   Fujita, Yuki ^a,b   Takahashi, Ryosuke ^c   Yamashita, Toshihide ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; NEOGENIN; REPULSIVE GUIDANCE MOLECULE A; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; ISOPROTEIN; NERVE PROTEIN; PEPTIDE; RGMA PROTEIN, HUMAN; RGMA PROTEIN, MOUSE; VON WILLEBRAND FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN CELL; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH CONE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; METABOLIC INHIBITION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; BRAIN CORTEX; CHEMICAL PHENOMENA; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; METHODOLOGY; NERVE CELL; PRENATAL DEVELOPMENT; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

MAMMALIA;

ANIMALS; BINDING SITES; CEREBRAL CORTEX; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GPI-LINKED PROTEINS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; NEURONS; PEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; VON WILLEBRAND FACTOR;

EID: 84857738203     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032791     Document Type: Article

References (22)

1. Stahl B, Muller B, von Boxberg Y, Cox EC, Bonhoeffer F, (1990) Biochemical characterization of a putative axonal guidance molecule of the chick visual system. Neuron 5: 735-743.
2. Monnier PP, Sierra A, Macchi P, Deitinghoff L, Andersen JS, et al. (2002) RGM is a repulsive guidance molecule for retinal axons. Nature 419: 392-395.
3. Yamashita T, Mueller BK, Hata K, (2007) Neogenin and repulsive guidance molecule signaling in the central nervous system. Curr Opin Neurobiol 17: 29-34.
4. Matsunaga E, Chedotal A, (2004) Repulsive guidance molecule/neogenin: a novel ligand-receptor system playing multiple roles in neural development. Dev Growth Differ 46: 481-486.
5. Mueller BK, Yamashita T, Schaffar G, Mueller R, (2006) The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system. Philos Trans R Soc Lond B Biol Sci 361: 1513-1529.
6. Niederkofler V, Salie R, Sigrist M, Arber S, (2004) Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J Neurosci 24: 808-818.
7. Schmidtmer J, Engelkamp D, (2004) Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr Patterns 4: 105-110.
8. Brinks H, Conrad S, Vogt J, Oldekamp J, Sierra A, et al. (2004) The repulsive guidance molecule RGMa is involved in the formation of afferent connections in the dentate gyrus. J Neurosci 24: 3862-3869.
9. Hata K, Fujitani M, Yasuda Y, Doya H, Saito T, et al. (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J Cell Biol 173: 47-58.
10. Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, et al. (2004) Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 6: 756-762.
11. Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ, (2003) Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. J Biol Chem 278: 32561-32568.
12. Severyn CJ, Shinde U, Rotwein P, (2009) Molecular biology, genetics and biochemistry of the repulsive guidance molecule family. Biochem J 422: 393-403.
13. Hata K, Kaibuchi K, Inagaki S, Yamashita T, (2009) Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol 184: 737-750.
14. Tassew NG, Chestopolava L, Beecroft R, Matsunaga E, Teng H, et al. (2008) Intraretinal RGMa is involved in retinotectal mapping. Mol Cell Neurosci 37: 761-769.
15. Fujita Y, Taniguchi J, Uchikawa M, Endo M, Hata K, et al. (2008) Neogenin regulates neuronal survival through DAP kinase. Cell Death Differ 15: 1593-1608.
16. Schwab JM, Conrad S, Monnier PP, Julien S, Mueller BK, et al. (2005) Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM). Eur J Neurosci 21: 1569-1576.
17. Schwab JM, Monnier PP, Schluesener HJ, Conrad S, Beschorner R, et al. (2005) Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain. Arch Neurol 62: 1561-1568.
18. Muramatsu R, Kubo T, Mori M, Nakamura Y, Fujitani M, et al. (2011) RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nat Med 17: 488-494.
19. Endo M, Yamashita T, (2009) Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. J Neurosci 29: 6649-6662.
20. Meyerhardt JA, Look AT, Bigner SH, Fearon ER, (1997) Identification and characterization of neogenin, a DCC-related gene. Oncogene 14: 1129-1136.
21. Llambi F, Lourenco FC, Gozuacik D, Guix C, Pays L, et al. (2005) The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. Embo J 24: 1192-1201.
22. Bartoe JL, McKenna WL, Quan TK, Stafford BK, Moore JA, et al. (2006) Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. J Neurosci 26: 3192-3205.