메뉴 건너뛰기




Volumn 36, Issue 2, 2012, Pages 163-172

Ovarian endometrioid adenocarcinoma: Incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability

Author keywords

Lynch syndrome; Microsatellite instability; Mismatch repair proteins; Ovarian cancer; Tumor infiltrating lymphocytes

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DNA BINDING PROTEIN; G T MISMATCH BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; MLH1 PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PMS2 PROTEIN, HUMAN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN MSH2; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 84857720240     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31823bc434     Document Type: Article
Times cited : (71)

References (54)
  • 1
    • 17644415807 scopus 로고    scopus 로고
    • Pathology and genetics of tumours of the breast and female genital organs
    • In Tavassoli FA, Devilee P, eds. Lyon: IARC Press
    • Lee KR, Tavassoli FA, Prat J, et al. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. In: Tavassoli FA, Devilee P, eds. Surface Epithelial-Stromal Tumors. Lyon: IARC Press; 2003:117-145.
    • (2003) Surface Epithelial-Stromal Tumors , pp. 117-145
    • Lee, K.R.1    Tavassoli, F.A.2    Prat, J.3
  • 2
    • 20444378403 scopus 로고    scopus 로고
    • Pathology and genetics of tumours of the breast and female genital organs
    • In Tavassoli FA, Devilee P, eds. Lyon: IARC Press
    • Silverberg SG, Kurman RJ, Nogales F, et al. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. In: Tavassoli FA, Devilee P, eds. Epithelial Tumors and Related Lesions. Lyon: IARC Press; 2003:221-232.
    • (2003) Epithelial Tumors and Related Lesions , pp. 221-232
    • Silverberg, S.G.1    Kurman, R.J.2    Nogales, F.3
  • 5
    • 58849130663 scopus 로고    scopus 로고
    • Cumulative lifetime incidence of extracolonic cancers in lynch syndrome: A report of 121 families with proven mutations
    • Barrow E, Robinson L, Alduaij W, et al. Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: A report of 121 families with proven mutations. Clin Genet. 2009;75:141-149.
    • (2009) Clin Genet , vol.75 , pp. 141-149
    • Barrow, E.1    Robinson, L.2    Alduaij, W.3
  • 6
    • 79958071334 scopus 로고    scopus 로고
    • Cancer risks associated with germline mutations in mlh1 msh2 and msh6 genes in lynch syndrome
    • Bonadona V, Bonaiti B, Olschwang S, et al. Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. JAMA. 2011;305:2304-2310.
    • (2011) JAMA , vol.305 , pp. 2304-2310
    • Bonadona, V.1    Bonaiti, B.2    Olschwang, S.3
  • 7
    • 0032013802 scopus 로고    scopus 로고
    • Molecular genetics of hereditary ovarian cancer
    • Boyd J. Molecular genetics of hereditary ovarian cancer. Oncology (Williston Park). 1998;12:399-406. (Pubitemid 128617828)
    • (1998) Oncology , vol.12 , Issue.3 , pp. 399-406
    • Boyd, J.1
  • 9
    • 0035097150 scopus 로고    scopus 로고
    • Cancer risk in young women at risk of hereditary nonpolyposis colorectal cancer: Implications for gynecologic surveillance
    • DOI 10.1006/gyno.2000.6065
    • Brown GJ, St John DJ, Macrae FA, et al. Cancer risk in young women at risk of hereditary nonpolyposis colorectal cancer: implications for gynecologic surveillance. Gynecol Oncol. 2001;80: 346-349. (Pubitemid 32207533)
    • (2001) Gynecologic Oncology , vol.80 , Issue.3 , pp. 346-349
    • Brown, G.J.E.1    St. John, D.J.B.2    Macrae, F.A.3    Aittomaki, K.4
  • 11
    • 2442670288 scopus 로고    scopus 로고
    • Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma
    • DOI 10.1016/j.humpath.2003.12.009
    • Cai KQ, Albarracin C, Rosen D, et al. Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma. Hum Pathol. 2004;35:552-559. (Pubitemid 38656938)
    • (2004) Human Pathology , vol.35 , Issue.5 , pp. 552-559
    • Cai, K.Q.1    Albarracin, C.2    Rosen, D.3    Zhong, R.4    Zheng, W.5    Luthra, R.6    Broaddus, R.7    Liu, J.8
  • 12
    • 10044266232 scopus 로고    scopus 로고
    • Molecular genetic alterations in endometrioid carcinomas of the ovary: Similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas
    • DOI 10.1016/j.humpath.2004.07.019, PII S0046817704004368
    • Catasus L, Bussaglia E, Rodrguez I, et al. Molecular genetic alterations in endometrioid carcinomas of the ovary: similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas. Hum Pathol. 2004;35:1360-1368. (Pubitemid 39601576)
    • (2004) Human Pathology , vol.35 , Issue.11 , pp. 1360-1368
    • Catasus, L.1    Bussaglia, E.2    Rodriguez, I.3    Gallardo, A.4    Pons, C.5    Irving, J.A.6    Prat, J.7
  • 13
    • 61349151645 scopus 로고    scopus 로고
    • Intraepithelial t cells and prognosis in ovarian carcinoma: Novel associations with stage, tumor type, and brca1 loss
    • Clarke B, Tinker AV, Lee CH, et al. Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss. Mod Pathol. 2009;22:393-402.
    • (2009) Mod Pathol , vol.22 , pp. 393-402
    • Clarke, B.1    Tinker, A.V.2    Lee, C.H.3
  • 14
    • 0029955159 scopus 로고    scopus 로고
    • The genetic attributable risk of breast and ovarian cancer
    • DOI 10.1002/(SICI)1097-0142(19960601)77:11<2318::AID-CNCR21>3.0. CO;2-Z
    • Claus EB, Schildkraut JM, Thompson WD, et al. The genetic attributable risk of breast and ovarian cancer. Cancer. 1996;77: 2318-2324. (Pubitemid 26162426)
    • (1996) Cancer , vol.77 , Issue.11 , pp. 2318-2324
    • Claus, E.B.1    Schildkraut, J.M.2    Thompson, W.D.3    Risch, N.J.4
  • 17
    • 34447314503 scopus 로고    scopus 로고
    • Ovarian cancer at young age: The contribution of mismatch-repair defects in a population-based series of epithelial ovarian cancer before age 40
    • DOI 10.1111/j.1525-1438.2007.00875.x
    • Domanska K, Malander S, Masback A, et al. Ovarian cancer at young age: the contribution of mismatch-repair defects in a population-based series of epithelial ovarian cancer before age 40. Int J Gynecol Cancer. 2007;17:789-793. (Pubitemid 47063326)
    • (2007) International Journal of Gynecological Cancer , vol.17 , Issue.4 , pp. 789-793
    • Domanska, K.1    Malander, S.2    Masback, A.3    Nilbert, M.4
  • 18
    • 67549138793 scopus 로고    scopus 로고
    • Selection of endometrial carcinomas for dna mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities
    • Garg K, Leitao MM Jr. Kauff ND, et al. Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities. Am J Surg Pathol. 2009; 33:925-933.
    • (2009) Am J Surg Pathol , vol.33 , pp. 925-933
    • Garg, K.1    Leitao Jr., M.M.2    Kauff, N.D.3
  • 19
    • 73349097564 scopus 로고    scopus 로고
    • Endometrial carcinomas in women aged 40 years and younger: Tumors associated with loss of dna mismatch repair proteins comprise a distinct clinicopathologic subset
    • Garg K, Shih K, Barakat R, et al. Endometrial carcinomas in women aged 40 years and younger: tumors associated with loss of DNA mismatch repair proteins comprise a distinct clinicopathologic subset. Am J Surg Pathol. 2009;33:1869-1877.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1869-1877
    • Garg, K.1    Shih, K.2    Barakat, R.3
  • 20
    • 0035575740 scopus 로고    scopus 로고
    • Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors
    • DOI 10.1002/1097-0142(20011201)92:11<2829::AID-CNCR10094>3.0.CO;2-3
    • Gras E, Catasus L, Arguelles R, et al. Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors. Cancer. 2001;92:2829-2836. (Pubitemid 33091919)
    • (2001) Cancer , vol.92 , Issue.11 , pp. 2829-2836
    • Gras, E.1    Catasus, L.2    Argelles, R.3    Moreno-Bueno, G.4    Palacios, J.5    Gamallo, C.6    Matias-Guiu, X.7    Prat, J.8
  • 21
    • 77349086189 scopus 로고    scopus 로고
    • Survival in women with mmr mutations and ovarian cancer: A multicentre study in lynch syndrome kindreds
    • Grindedal EM, Renkonen-Sinisalo L, Vasen H, et al. Survival in women with MMR mutations and ovarian cancer: A multicentre study in Lynch syndrome kindreds. J Med Genet. 2010;47:99-102.
    • (2010) J Med Genet , vol.47 , pp. 99-102
    • Grindedal, E.M.1    Renkonen-Sinisalo, L.2    Vasen, H.3
  • 23
    • 21544457787 scopus 로고    scopus 로고
    • Synchronous endometrioid carcinomas of the uterine corpus and ovary: Alterations in the β-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis
    • DOI 10.1016/j.humpath.2005.03.005, PII S0046817705001292
    • Irving JA, Catasus L, Gallardo A, et al. Synchronous endometrioid carcinomas of the uterine corpus and ovary: Alterations in the betacatenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis. Hum Pathol. 2005;36:605-619. (Pubitemid 40922566)
    • (2005) Human Pathology , vol.36 , Issue.6 , pp. 605-619
    • Irving, J.A.1    Catasus, L.2    Gallardo, A.3    Bussaglia, E.4    Romero, M.5    Matias-Guiu, X.6    Prat, J.7
  • 24
    • 70350439453 scopus 로고    scopus 로고
    • Ten years after mutation testing for lynch syndrome: Cancer incidence and outcome in mutation-positive and mutation-negative family members
    • Jarvinen HJ, Renkonen-Sinisalo L, ktan-Collan K, et al. Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol. 2009;27:4793-4797.
    • (2009) J Clin Oncol , vol.27 , pp. 4793-4797
    • Jarvinen, H.J.1    Renkonen-Sinisalo, L.2    Ktan-Collan, K.3
  • 25
    • 47249125360 scopus 로고    scopus 로고
    • Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and younger
    • Jensen KC, Mariappan MR, Putcha GV, et al. Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and younger. Am J Surg Pathol. 2008;32:1029-1037.
    • (2008) Am J Surg Pathol , vol.32 , pp. 1029-1037
    • Jensen, K.C.1    Mariappan, M.R.2    Putcha, G.V.3
  • 26
    • 10944266090 scopus 로고    scopus 로고
    • Frequent microsatellite instability in synchronous ovarian and endometrial adenocarcinoma and its usefulness for differential diagnosis
    • DOI 10.1016/j.humpath.2004.08.011, PII S0046817704004666
    • Kaneki E, Oda Y, Ohishi Y, et al. Frequent microsatellite instability in synchronous ovarian and endometrial adenocarcinoma and its usefulness for differential diagnosis. Hum Pathol. 2004;35:1484-1493. (Pubitemid 40017988)
    • (2004) Human Pathology , vol.35 , Issue.12 , pp. 1484-1493
    • Kaneki, E.1    Oda, Y.2    Ohishi, Y.3    Tamiya, S.4    Oda, S.5    Hirakawa, T.6    Nakano, H.7    Tsuneyoshi, M.8
  • 27
    • 34848847148 scopus 로고    scopus 로고
    • Screening and prevention of hereditary gynecologic cancers
    • DOI 10.1053/j.seminoncol.2007.07.004, PII S0093775407001418, Breast and Colorectal Cancer Genetics for Practicing Oncologists
    • Kehoe SM, Kauff ND. Screening and prevention of hereditary gynecologic cancers. Semin Oncol. 2007;34:406-410. (Pubitemid 47503272)
    • (2007) Seminars in Oncology , vol.34 , Issue.5 , pp. 406-410
    • Kehoe, S.M.1    Kauff, N.D.2
  • 28
    • 0029122057 scopus 로고
    • Microsatellite instability in endometrial carcinomas: Frequent replication errors in tumors of early onset and/or of poorly differentiated type
    • Kobayashi K, Sagae S, Kudo R, et al. Microsatellite instability in endometrial carcinomas: frequent replication errors in tumors of early onset and/or of poorly differentiated type. Genes Chromosomes Cancer. 1995;14:128-132.
    • (1995) Genes Chromosomes Cancer , vol.14 , pp. 128-132
    • Kobayashi, K.1    Sagae, S.2    Kudo, R.3
  • 32
    • 46449117480 scopus 로고    scopus 로고
    • Hereditary gynecologic cancers: Differential diagnosis, surveillance, management and surgical prophylaxis
    • Lu KH. Hereditary gynecologic cancers: differential diagnosis, surveillance, management and surgical prophylaxis. Fam Cancer. 2008;7:53-58.
    • (2008) Fam Cancer , vol.7 , pp. 53-58
    • Lu, K.H.1
  • 34
    • 63549096634 scopus 로고    scopus 로고
    • Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management
    • Lynch HT, Casey MJ, Snyder CL, et al. Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management. Mol Oncol. 2009;3:97-137.
    • (2009) Mol Oncol , vol.3 , pp. 97-137
    • Lynch, H.T.1    Casey, M.J.2    Snyder, C.L.3
  • 35
    • 0017716034 scopus 로고
    • Role of heredity in multiple primary cancer
    • Lynch HT, Harris RE, Lynch PM, et al. Role of heredity in multiple primary cancer. Cancer. 1977;40:1849-1854. (Pubitemid 8216956)
    • (1977) Cancer , vol.40 , Issue.4 SUPPL. , pp. 1849-1854
    • Lynch, H.T.1    Harris, R.E.2    Lynch, P.M.3
  • 36
    • 33646408125 scopus 로고    scopus 로고
    • The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer
    • Malander S, Rambech E, Kristoffersson U, et al. The contribution of the hereditary nonpolyposis colorectal cancer syndrome to the development of ovarian cancer. Gynecol Oncol. 2006;101: 238-243.
    • (2006) Gynecol Oncol , vol.101 , pp. 238-243
    • Malander, S.1    Rambech, E.2    Kristoffersson, U.3
  • 37
    • 0022648252 scopus 로고
    • Clinical features of colorectal carcinoma in cancer family syndrome
    • Mecklin JP, Jarvinen HJ. Clinical features of colorectal carcinoma in cancer family syndrome. Dis Colon Rectum. 1986;29:160-164. (Pubitemid 16124067)
    • (1986) Diseases of the Colon and Rectum , vol.29 , Issue.3 , pp. 160-164
    • Mecklin, J.-P.1    Jarvinen, H.J.2
  • 39
    • 64049094855 scopus 로고    scopus 로고
    • Revised figo staging for carcinoma of the vulva, cervix, and endometrium
    • Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 2009;105:103-104.
    • (2009) Int J Gynaecol Obstet , vol.105 , pp. 103-104
    • Pecorelli, S.1
  • 40
    • 69549110049 scopus 로고    scopus 로고
    • Lynch syndrome screening strategies among newly diagnosed endometrial cancer patients
    • Resnick K, Straughn JM Jr. Backes F, et al. Lynch syndrome screening strategies among newly diagnosed endometrial cancer patients. Obstet Gynecol. 2009;114:530-536.
    • (2009) Obstet Gynecol , vol.114 , pp. 530-536
    • Resnick, K.1    Straughn Jr., J.M.2    Backes, F.3
  • 41
    • 67349088318 scopus 로고    scopus 로고
    • Current and emerging trends in lynch syndrome identification in women with endometrial cancer
    • Resnick KE, Hampel H, Fishel R, et al. Current and emerging trends in Lynch syndrome identification in women with endometrial cancer. Gynecol Oncol. 2009;114:128-134.
    • (2009) Gynecol Oncol , vol.114 , pp. 128-134
    • Resnick, K.E.1    Hampel, H.2    Fishel, R.3
  • 42
    • 33750361148 scopus 로고    scopus 로고
    • Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma
    • DOI 10.1038/modpathol.3800672, PII 3800672
    • Rosen DG, Cai KQ, Luthra R, et al. Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma. Mod Pathol. 2006;19:1414-1420. (Pubitemid 44624159)
    • (2006) Modern Pathology , vol.19 , Issue.11 , pp. 1414-1420
    • Rosen, D.G.1    Cai, K.Q.2    Luthra, R.3    Liu, J.4
  • 45
    • 36749095643 scopus 로고    scopus 로고
    • Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer
    • DOI 10.1016/j.humpath.2007.05.022, PII S0046817707002997
    • Shia J, Black D, Hummer AJ, et al. Routinely assessed morphological features correlate with microsatellite instability status in endometrial cancer. Hum Pathol. 2008;39:116-125. (Pubitemid 350216167)
    • (2008) Human Pathology , vol.39 , Issue.1 , pp. 116-125
    • Shia, J.1    Black, D.2    Hummer, A.J.3    Boyd, J.4    Soslow, R.A.5
  • 46
    • 33644831829 scopus 로고    scopus 로고
    • Women with synchronous primary cancers of the endometrium and ovary do they have lynch syndrome?
    • Soliman PT, Broaddus RR, Schmeler KM, et al. Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? J Clin Oncol. 2005;23:9344-9350.
    • (2005) J Clin Oncol , vol.23 , pp. 9344-9350
    • Soliman, P.T.1    Broaddus, R.R.2    Schmeler, K.M.3
  • 48
    • 0035360815 scopus 로고    scopus 로고
    • Application of the National Cancer Institute international criteria for determination of microsatellite instability in ovarian cancer
    • Sood AK, Holmes R, Hendrix MJ, et al. Application of the National Cancer Institute international criteria for determination of microsatellite instability in ovarian cancer. Cancer Res. 2001;61: 4371-4374. (Pubitemid 32685761)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4371-4374
    • Sood, A.K.1    Holmes, R.2    Hendrix, M.J.C.3    Buller, R.E.4
  • 49
    • 22944460428 scopus 로고    scopus 로고
    • Microsatellite status and immunohistochemical features of ovarian clear-cell carcinoma
    • Ueda H, Watanabe Y, Nakai H, et al. Microsatellite status and immunohistochemical features of ovarian clear-cell carcinoma. Anticancer Res. 2005;25:2785-2788. (Pubitemid 41044662)
    • (2005) Anticancer Research , vol.25 , Issue.4 , pp. 2785-2788
    • Ueda, H.1    Watanabe, Y.2    Nakai, H.3    Hemmi, H.4    Koi, M.5    Hoshiai, I.6
  • 53
    • 0034754947 scopus 로고    scopus 로고
    • Simultaneously detected endometrial and ovarian carcinomas - A prospective clinicopathologic study of 74 cases: A Gynecologic Oncology Group study
    • DOI 10.1006/gyno.2001.6400
    • Zaino R, Whitney C, Brady MF, et al. Simultaneously detected endometrial and ovarian carcinomas: A prospective clinicopathologic study of 74 cases: A gynecologic oncology group study. Gynecol Oncol. 2001;83:355-362. (Pubitemid 33033079)
    • (2001) Gynecologic Oncology , vol.83 , Issue.2 , pp. 355-362
    • Zaino, R.1    Whitney, C.2    Brady, M.F.3    DeGeest, K.4    Burger, R.A.5    Buller, R.E.6
  • 54
    • 63549130725 scopus 로고    scopus 로고
    • Loss of dna mismatch repair protein hmsh6 in ovarian cancer is histotype-specific
    • Zhai QJ, Rosen DG, Lu K, et al. Loss of DNA mismatch repair protein hMSH6 in ovarian cancer is histotype-specific. Int J Clin Exp Pathol. 2008;1:502-509.
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 502-509
    • Zhai, Q.J.1    Rosen, D.G.2    Lu, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.