메뉴 건너뛰기




Volumn 168, Issue 1, 2012, Pages 95-104

Transglutaminase 2 expression is enhanced synergistically by interferon-γ and tumour necrosis factor-α in human small intestine

Author keywords

Coeliac disease; IFN ; Inflammation; Transglutaminase 2

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 15; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; SALAZOSULFAPYRIDINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84857716111     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04545.x     Document Type: Article
Times cited : (36)

References (30)
  • 1
    • 0037317032 scopus 로고    scopus 로고
    • Transglutaminases: crosslinking enzymes with pleiotropic functions
    • Lorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 2003; 4:140-56.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 140-156
    • Lorand, L.1    Graham, R.M.2
  • 2
    • 0036804796 scopus 로고    scopus 로고
    • Transglutaminase 2: an enigmatic enzyme with diverse functions
    • Fesus L, Piacentini M. Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem Sci 2002; 27:534-9.
    • (2002) Trends Biochem Sci , vol.27 , pp. 534-539
    • Fesus, L.1    Piacentini, M.2
  • 3
    • 77956916373 scopus 로고    scopus 로고
    • Transglutaminase 2: a multi-functional protein in multiple subcellular compartments
    • Park D, Choi SS, Ha K-S. Transglutaminase 2: a multi-functional protein in multiple subcellular compartments. Amino Acids 2010; 39:619-31.
    • (2010) Amino Acids , vol.39 , pp. 619-631
    • Park, D.1    Choi, S.S.2    Ha, K.-S.3
  • 4
    • 84857760792 scopus 로고    scopus 로고
    • Homo sapiens transglutaminase 2 mRNA, complete cds. GenBank Accession number: AY675221.1. 2004 Ago. Available at: (accessed 4 August 2004).
    • Bayardo MP, De Urraza P, Chirdo FG. Homo sapiens transglutaminase 2 mRNA, complete cds. GenBank Accession number: AY675221.1. 2004 Ago. Available at: (accessed 4 August 2004).
    • Bayardo, M.P.1    De Urraza, P.2    Chirdo, F.G.3
  • 5
    • 20444363472 scopus 로고    scopus 로고
    • Transglutaminase 2 in the balance of cell death and survival
    • Fésüs L, Szondy Z. Transglutaminase 2 in the balance of cell death and survival. FEBS Lett 2005; 579:3297-302.
    • (2005) FEBS Lett , vol.579 , pp. 3297-3302
    • Fésüs, L.1    Szondy, Z.2
  • 6
    • 33744496065 scopus 로고    scopus 로고
    • Transglutaminase 2 in inflammation
    • Kim S-Y. Transglutaminase 2 in inflammation. Front Biosci 2006; 11:3026-35.
    • (2006) Front Biosci , vol.11 , pp. 3026-3035
    • Kim, S.-Y.1
  • 7
    • 78049427740 scopus 로고    scopus 로고
    • Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancer
    • Mehta K, Kumar A, Kim HI. Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancer. Biochem Pharmacol 2010; 80:1921-9.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1921-1929
    • Mehta, K.1    Kumar, A.2    Kim, H.I.3
  • 8
    • 78649512556 scopus 로고    scopus 로고
    • The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are peptide fragments harboring celiac disease T-cell epitopes
    • Dørum S, Arntzen MØ, Qiao S-W etal. The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are peptide fragments harboring celiac disease T-cell epitopes. PLoS ONE 2010; 5:e14056.
    • (2010) PLoS ONE , vol.5
    • Dørum, S.1    Arntzen, M.2    Qiao, S.-W.3
  • 9
    • 0031779478 scopus 로고    scopus 로고
    • Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
    • Molberg O, Mcadam SN, Körner R etal. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998; 4:713-7.
    • (1998) Nat Med , vol.4 , pp. 713-717
    • Molberg, O.1    Mcadam, S.N.2    Körner, R.3
  • 10
    • 79953057255 scopus 로고    scopus 로고
    • Integration of genetic and immunological insights into a model of celiac disease pathogenesis
    • Abadie V, Sollid LM, Barreiro LB, Jabri B. Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol 2011; 29:493-525.
    • (2011) Annu Rev Immunol , vol.29 , pp. 493-525
    • Abadie, V.1    Sollid, L.M.2    Barreiro, L.B.3    Jabri, B.4
  • 11
    • 11144233953 scopus 로고    scopus 로고
    • Transglutaminase 2 induces NFκB activation via a novel pathway in BV-2 microglia
    • Lee J, Kim YS, Choi DH etal. Transglutaminase 2 induces NFκB activation via a novel pathway in BV-2 microglia. J Biol Chem 2004; 279:53725-35.
    • (2004) J Biol Chem , vol.279 , pp. 53725-53735
    • Lee, J.1    Kim, Y.S.2    Choi, D.H.3
  • 12
    • 0031885898 scopus 로고    scopus 로고
    • TNFα modulates expression of the tissue transglutaminase gene in liver cells
    • Kuncio GS, Tsyganskaya M, Zhu J etal. TNFα modulates expression of the tissue transglutaminase gene in liver cells. Am J Physiol 1998; 274(Pt 1):G240-245.
    • (1998) Am J Physiol , vol.274 , Issue.PART 1
    • Kuncio, G.S.1    Tsyganskaya, M.2    Zhu, J.3
  • 14
    • 0036377833 scopus 로고    scopus 로고
    • γIFN induces transglutaminase 2 expression in rat small intestinal cells
    • Kim S-Y, Jeong E-J, Steinert PM. γIFN induces transglutaminase 2 expression in rat small intestinal cells. J Interferon Cytokine Res 2002; 22:677-82.
    • (2002) J Interferon Cytokine Res , vol.22 , pp. 677-682
    • Kim, S.-Y.1    Jeong, E.-J.2    Steinert, P.M.3
  • 15
    • 34447286702 scopus 로고    scopus 로고
    • Transglutaminase 2 inhibitors and their therapeutic role in disease states
    • Siegel M, Khosla C. Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacol Ther 2007; 115:232-45.
    • (2007) Pharmacol Ther , vol.115 , pp. 232-245
    • Siegel, M.1    Khosla, C.2
  • 16
    • 21744455909 scopus 로고    scopus 로고
    • Characterizing monoclonal antibody epitopes by filtered gene fragment phage display
    • Di Niro R, Ferrara F, Not T etal. Characterizing monoclonal antibody epitopes by filtered gene fragment phage display. Biochem J 2005; 388(Pt 3):889-94.
    • (2005) Biochem J , vol.388 , Issue.PART 3 , pp. 889-894
    • Di Niro, R.1    Ferrara, F.2    Not, T.3
  • 18
    • 77749318553 scopus 로고    scopus 로고
    • Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa
    • Luciani A, Villella VR, Vasaturo A etal. Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa. Gut 2010; 59:311-9.
    • (2010) Gut , vol.59 , pp. 311-319
    • Luciani, A.1    Villella, V.R.2    Vasaturo, A.3
  • 19
    • 79961159239 scopus 로고    scopus 로고
    • Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice
    • Oh K, Park H-B, Byoun O-J etal. Epithelial transglutaminase 2 is needed for T cell interleukin-17 production and subsequent pulmonary inflammation and fibrosis in bleomycin-treated mice. J Exp Med 2011; 208:1707-19.
    • (2011) J Exp Med , vol.208 , pp. 1707-1719
    • Oh, K.1    Park, H.-B.2    Byoun, O.-J.3
  • 20
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351(Pt 1):95-105.
    • (2000) Biochem J , vol.351 , Issue.PART 1 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 21
    • 36549040859 scopus 로고    scopus 로고
    • The selectivity of protein kinase inhibitors: a further update
    • Bain J, Plater L, Elliott M etal. The selectivity of protein kinase inhibitors: a further update. Biochem J 2007; 408(Pt 3):297-315.
    • (2007) Biochem J , vol.408 , Issue.PART 3 , pp. 297-315
    • Bain, J.1    Plater, L.2    Elliott, M.3
  • 22
    • 75749146285 scopus 로고    scopus 로고
    • Biochemical mechanisms of resistance to small-molecule protein kinase inhibitors
    • Krishnamurty R, Maly DJ. Biochemical mechanisms of resistance to small-molecule protein kinase inhibitors. ACS Chem Biol 2010; 5:121-38.
    • (2010) ACS Chem Biol , vol.5 , pp. 121-138
    • Krishnamurty, R.1    Maly, D.J.2
  • 23
    • 52949108413 scopus 로고    scopus 로고
    • Regulation of neutral sphingomyelinase-2 (nSMase2) by TNFα involves protein kinase C-δ in lung epithelial cells
    • Clarke CJ, Guthrie JM, Hannun YA. Regulation of neutral sphingomyelinase-2 (nSMase2) by TNFα involves protein kinase C-δ in lung epithelial cells. Mol Pharmacol 2008; 74:1022-32.
    • (2008) Mol Pharmacol , vol.74 , pp. 1022-1032
    • Clarke, C.J.1    Guthrie, J.M.2    Hannun, Y.A.3
  • 24
    • 0037064052 scopus 로고    scopus 로고
    • IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NFκB activation in both primary and intestinal epithelial cell lines
    • Haller D, Russo MP, Sartor RB, Jobin C. IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NFκB activation in both primary and intestinal epithelial cell lines. J Biol Chem 2002; 277:38168-78.
    • (2002) J Biol Chem , vol.277 , pp. 38168-38178
    • Haller, D.1    Russo, M.P.2    Sartor, R.B.3    Jobin, C.4
  • 25
    • 67650303113 scopus 로고    scopus 로고
    • The AKT axis as a therapeutic target in autoimmune diseases
    • Wu T, Mohan C. The AKT axis as a therapeutic target in autoimmune diseases. Endocr Metab Immune Disord Drug Targets 2009; 9:145-50.
    • (2009) Endocr Metab Immune Disord Drug Targets , vol.9 , pp. 145-150
    • Wu, T.1    Mohan, C.2
  • 26
    • 70349249976 scopus 로고    scopus 로고
    • Tissue transglutaminase enhances collagen type II-induced arthritis and modifies the immunodominant T-cell epitope CII260-270
    • Dzhambazov B, Lindh I, Engström A, Holmdahl R. Tissue transglutaminase enhances collagen type II-induced arthritis and modifies the immunodominant T-cell epitope CII260-270. Eur J Immunol 2009; 39:2412-23.
    • (2009) Eur J Immunol , vol.39 , pp. 2412-2423
    • Dzhambazov, B.1    Lindh, I.2    Engström, A.3    Holmdahl, R.4
  • 27
    • 61349176513 scopus 로고    scopus 로고
    • Mucosal tissue transglutaminase expression in celiac disease
    • Villanacci V, Not T, Sblattero D etal. Mucosal tissue transglutaminase expression in celiac disease. J Cell Mol Med 2009; 13:334-40.
    • (2009) J Cell Mol Med , vol.13 , pp. 334-340
    • Villanacci, V.1    Not, T.2    Sblattero, D.3
  • 28
    • 65249178698 scopus 로고    scopus 로고
    • Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver
    • Elli L, Bergamini CM, Bardella MT, Schuppan D. Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver. Dig Liver Dis 2009; 41:541-50.
    • (2009) Dig Liver Dis , vol.41 , pp. 541-550
    • Elli, L.1    Bergamini, C.M.2    Bardella, M.T.3    Schuppan, D.4
  • 29
    • 47249102033 scopus 로고    scopus 로고
    • Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation
    • Maiuri L, Luciani A, Giardino I etal. Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation. J Immunol 2008; 180:7697-705.
    • (2008) J Immunol , vol.180 , pp. 7697-7705
    • Maiuri, L.1    Luciani, A.2    Giardino, I.3
  • 30
    • 77955455920 scopus 로고    scopus 로고
    • Potential of transglutaminase 2 as a therapeutic target
    • Caccamo D, Currò M, Ientile R. Potential of transglutaminase 2 as a therapeutic target. Expert Opin Ther Targets 2010; 14:989-1003.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 989-1003
    • Caccamo, D.1    Currò, M.2    Ientile, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.