Comparative biochemistry of GH3, GH20 and GH84 β-N-acetyl-D-hexosaminidases and recent progress in selective inhibitor discovery

Current Drug Targets

Volumn 13, Issue 4, 2012, Pages 512-525

  Liu, Tian ^a   Yan, Jun ^a   Yang, Qing ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Catalytic mechanism; Drug discovery; Glycosyl hydrolase; Inhibition; Pesticide; Structure; Target

Indexed keywords

ASPARAGINE; BETA N ACETYL DEXTRO HEXOSAMINIDASE; BETA N ACETYLHEXOSAMINIDASE; CYSTINE; HISTONE; HYDROXYL GROUP; METHIONINE; N ACETYL BETA GLUCOSAMINIDASE; THREONINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ALPHA HELIX; BETA SHEET; BIOCHEMISTRY; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; GLYCOSYLATION; HUMAN; HYDROGEN BOND; NONHUMAN; REVIEW; STATIC ELECTRICITY;

ANIMALS; BETA-N-ACETYLHEXOSAMINIDASES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; MOLECULAR BIOLOGY; PESTICIDES; PROTEIN CONFORMATION;

EID: 84857696033     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012799499730     Document Type: Review

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