Experimental cerebral malaria develops independently of caspase recruitment domain-containing protein 9 signaling

Infection and Immunity

Volumn 80, Issue 3, 2012, Pages 1274-1279

  Hafalla, Julius Clemence R ^a   Burgold, Jan ^b,e   Dorhoi, Anca ^b   Gross, Olaf ^c,d   Ruland, Jürgen ^c   Kaufmann, Stefan H E ^b   Matuschewski, Kai ^b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE RECRUITMENT DOMAIN CONTAINING PROTEIN 9; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN MALARIA; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; INFLAMMATION; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; MICROVASCULATURE; MOUSE; NONHUMAN; PATHOGENESIS; PLASMODIUM BERGHEI; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MALARIA, CEREBRAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLASMODIUM BERGHEI; SIGNAL TRANSDUCTION;

EID: 84857665950     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.06033-11     Document Type: Article

References (20)

1. Amani V, et al. 2000. Involvement of IFN-gamma receptor-mediated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection. Eur. J. Immunol. 30:1646-1655.
2. Belnoue E, et al. 2002. On the pathogenic role of brain-sequestered alpha beta CD8+ T cells in experimental cerebral malaria. J. Immunol. 169:6369-6375.
3. Bertin J, et al. 2000. CARD9 is a novel caspase recruitment domaincontaining protein that interacts with BCL10/CLAP and activates NFkappa B. J. Biol. Chem. 275:41082-41086.
4. Claser C, et al. 2011. CD8 T cells and IFN-gamma mediate the timedependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria. PLoS One 6:e18720.
5. Coban C, et al. 2007. Pathological role of Toll-like receptor signaling in cerebral malaria. Int. Immunol. 19:67-79.
6. Dorhoi A, et al. 2010. The adaptor molecule CARD9 is essential for tuberculosis control. J. Exp. Med. 207:777-792.
7. Engwerda C, Belnoue E, Gruner AC, Renia L. 2005. Experimental models of cerebral malaria. Curr. Top. Microbiol. Immunol. 297:103-143.
8. Finney CA, Lu Z, LeBourhis L, Philpott DJ, Kain KC. 2009. Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria. Am. J. Trop. Med. Hyg. 80:718-722.
9. Grau GE, et al. 1989. Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc. Natl. Acad. Sci. U. S. A. 86:5572-5574.
10. Griffith JW, et al. 2007. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J. Infect. Dis. 196:1553-1564.
11. Gross O, et al. 2006. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442:651-656.
12. Hsu YM, et al. 2007. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8:198-205.
13. Irani DN, Griffin DE. 1991. Isolation of brain parenchymal lymphocytes for flow cytometric analysis. Application to acute viral encephalitis. J. Immunol. Meth. 139:223-231.
14. Kordes M, Matuschewski K, Hafalla JC. 2011. Caspase-1 activation of interleukin-1β (IL-1β) and IL-18 is dispensable for induction of experimental cerebral malaria. Infect. Immun. 79:3633-3641.
15. Krishnegowda G, et al. 2005. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J. Biol. Chem. 280:8606-8616.
16. LeibundGut-Landmann S, et al. 2007. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8:630-638.
17. Lepenies B, et al. 2008. Induction of experimental cerebral malaria is independent of TLR2/4/9. Med. Microbiol. Immunol. 197:39-44.
18. Rai D, Pham NL, Harty JT, Badovinac VP. 2009. Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts. J. Immunol. 183:7672-7681.
19. Togbe D, et al. 2007. Murine cerebral malaria development is independent of Toll-like receptor signaling. Am. J. Pathol. 170:1640-1648.
20. World Health Organization. 2009. Malaria report. WHO, Geneva, Switzerland.