Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 3, 2012, Pages 786-798

  Francischetti, Ivo M B ^a   Oliveira, Carlo J ^a,b   Ostera, Graciela R ^a   Yager, Stephanie B ^a   Debierre Grockiego, Françoise ^c,d   Carregaro, Vanessa ^a,e   Jaramillo Gutierrez, Giovanna ^a   Hume, Jen C C ^a,f   Jiang, Lubin ^a   Moretz, Samuel E ^a   Lin, Christina K ^a   Ribeiro, José M C ^a   Long, Carole A ^a   Vickers, Brandi K ^a   Schwarz, Ralph T ^c,g,h   Seydel, Karl B ^a   Iacobelli, Massimo ⁱ   Ackerman, Hans C ^a   Srinivasan, Prakash ^a   Gomes, Regis B ^a   Wang, Xunde ^j   Monteiro, Robson Q ^k   Kotsyfakis, Michail ^a,l   Sá Nunes, Anderson ^a,e   Waisberg, Michael ^a   more..

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d Parasite Immunology Vaccinology and Anti infectious Biotherapy   (France)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^g UNIV LILLE   (France)

^h MICHIGAN STATE UNIVERSITY   (United States)

ⁱ Gentium SpA   (Italy)

^j NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^k FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^l INSTITUTE OF PARASITOLOGY   (Czech Republic)

more..

Author keywords

anticoagulants; blood coagulation; endothelium; microcirculation; vascular biology

Indexed keywords

8 (4 SULFOPHENYL)THEOPHYLLINE; BLOOD CLOTTING FACTOR 10A; DEFIBROTIDE; GAMMA INTERFERON; GLYCOSYLPHOSPHATIDYLINOSITOL; THROMBOPLASTIN; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ANTICOAGULANT THERAPY; ARTICLE; BLOOD CLOTTING; BRAIN MALARIA; CELL INVASION; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE SEVERITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ERYTHROCYTE; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PARASITEMIA; PATHOGENESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICOAGULANTS; ANTIMALARIALS; BLOOD COAGULATION; CELLS, CULTURED; COMPLEMENT ACTIVATION; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FEMALE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HEMOGLOBINS; HUMANS; INFLAMMATION MEDIATORS; MALARIA, CEREBRAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NITRIC OXIDE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLATELET AGGREGATION; POLYDEOXYRIBONUCLEOTIDES; RECEPTORS, PURINERGIC P1; SEVERITY OF ILLNESS INDEX; THROMBOPLASTIN; TIME FACTORS;

EID: 84857659187     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.240291     Document Type: Article

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