Multimodal MRI of Experimental Stroke

Translational Stroke Research

Volumn 3, Issue 1, 2012, Pages 8-15

  Duong, Timothy Q ^a,b,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

ADC; CBF; DWI; Experimental stroke model; fMRI; Hyperperfusion; Magnetic resonance imaging; MRI; Oxygen challenge; Perfusion diffusion mismatch; Predictive mode; PWI; Rats; Rodents

Indexed keywords

ARTIFICIAL NEURAL NETWORK; BOLD SIGNAL; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; IMAGE ANALYSIS; MAGNETIC RESONANCE ANGIOGRAPHY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; REVIEW; SPIN LABELING; SUPPORT VECTOR MACHINE; VOXEL BASED MORPHOMETRY;

EID: 84857658370     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-011-0140-y     Document Type: Review

References (67)

1. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ, Hailpern SM, Heit JA, Ho PM, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J. Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation. 2011; 123: e18-e209.
2. Davis SM, Donnan GA. 4. 5 hours: the new time window for tissue plasminogen activator in stroke. Stroke. 2009; 40: 2266-7.
3. Hoehn-Berlage M, Norris DG, Kohno K, Mies G, Leibfritz D, Hossmann K-A. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances. J Cereb Blood Flow Metab. 1995; 15: 1002-11.
4. Back M. T., Hoehn-Berlage, PhD, M., Kohno, MD, K., Hossmann, PhD, MD, K-A. Diffusion nuclear magnetic resonance imaging in experimental stroke correlation with cerebral metabolites. Stroke. 1994; 25: 494-500.
5. Kohno K, Hoehn-Berlage M, Mies G, Back T, Hossmann KA. Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction. Magn Reson Imag. 1995; 13: 73-80.
6. Albers GW. Expanding the window for thrombolytic therapy in acute stroke: the potential role of acute MRI for patient selection. Stroke. 1999; 30: 2230-7.
7. Heiss WD, Graf R. The ischemic penumbra. Curr Opin Neurol. 1994; 7: 11-9.
8. NINDS. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorder, and Stroke rt-PA Stroke study group. N Engl J Med. 1995; 333: 1581-7.
9. Rohl L, Ostergaard L, Simonsen CZ, Vestergaard-Poulsen P, Andersen G, Sakoh M, Le Bihan D, Gyldensted C. Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient. Stroke. 2001; 32: 1140-6.
10. Schlaug G, Benfield A, Baird AE, Siewert B, Lovblad KO, Parker RA, Edelman RR, Warach S. The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology. 1999; 53: 1528-37.
11. Kidwell CS, Alger JR, Saver JL. Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke. 2003; 34: 2729-35.
12. Moseley ME, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J, Wendland MF, Weinstein PR. Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med. 1990; 14: 330-46.
13. Duong TQ, Ackerman JJH, Ying HS, Neil JJ. Evaluation of extra- and intracellular apparent diffusion in normal and globally ischemic rat brain via 19 F NMR. Magn Reson Med. 1998; 40: 1-13.
14. Barbier EL, Lamalle L, Decorps M. Methodology of brain perfusion imaging. J Magn Reson Imaging. 2001; 13: 496-520.
15. Calamante F, Thomas DL, Pell GS, Wiersma J, Turner R. Measuring cerebral blood flow using magnetic resonance imaging techniques. J Cereb Blood Flow Metab. 1999; 19: 701-35.
16. Wong EC, Buxton RB, Frank LR. A theoretical and experimental comparison of continuous and pulsed arterial spin labeling techniques for quantitative perfusion imaging. Magn Reson Med. 1998; 40: 348-55.
17. Shen Q, Meng X, Fisher M, Sotak CH, Duong TQ. Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging. J Cereb Blood Flow and Metab. 2003; 23: 1479-88.
18. Meng X, Shen Q, Li F, Ratan M, Fisher M, Sotak CH, Duong TQ. Quantitative assessment of temporal changes in the "perfusion/diffusion mismatch" following focal cerebral ischema in the rat brain. 2003; Toronto, Canada. p 303.
19. Shen Q, Fisher M, Sotak CH, Duong TQ. Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging. J Cereb Blood Flow Metab. 2004; 24: 280-90.
20. Shen Q, Ren H, Cheng H, Fisher M, Duong TQ. Functional, perfusion and diffusion MRI of acute focal ischemic brain injury. J Cereb Blood Flow and Metab. 2005; 25: 1265-79.
21. Tagaris GA, Richter W, Kim SG, Pellizzer G, Andersen P, Ugurbil K, Georgopoulos AP. Functional magnetic resonance imaging of mental rotation and memory scanning: a multidimensional scaling analysis of brain activation patterns. Brain Res Brain Res Rev. 1998; 26: 106-12.
22. Bardutsky J, Meng X, Bouley J, Duong TQ, Ratan R, Fisher M. Effects of IV dimethyl sulfoxide on ischemia evolution in permanently occluded rats. J Cereb Blood Flow and Metab. 2005; 25: 968-77.
23. Shen Q, Ren H, Bouley J, Fisher M, Duong TQ. Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data. J Cereb Blood Flow and Metab. 2004; 24: 887-97.
24. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats. Stroke. 2006; 37: 2593-600.
25. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2006; 26: 1451-62.
26. Ren H, Shen Q, Bardutzky J, Fisher M, Duong TQ. Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model. Magn Reson Med. 2004; 52: 1328-35.
27. Bardutzky J, Shen Q, Bouley J, Sotak CH, Duong TQ, Fisher M. Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution. Brain Res. 2005; 1043: 155-62.
28. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim S-G, Merkle H, Ugurbil K. Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA. 1992; 89: 5951-5.
29. Roy CS, Sherrington CS. On the regulation of blood supply of the brain. J Physiol. 1890; 1: 85-108.
30. Liu ZM, Schmidt KF, Sicard KM, Duong TQ. Imaging oxygen consumption in forepaw somatosensory stimulation in rats under isoflurane anesthesia. Magn Reson Med. 2004; 52: 277-85.
31. Sicard KM, Duong TQ. Effects of hypoxia, hyperoxia and hypercapnia on baseline and stimulus-evoked BOLD, CBF and CMRO2 in spontaneously breathing animals. NeuroImage. 2005; 25: 850-8.
32. Silva A, Lee S-P, Yang C, Iadecola C, Kim S-G. Simultaneous BOLD and perfusion functional MRI during forepaw stimulation in rats. J Cereb Blood Flow Metab. 1999; 19: 871-9.
33. Duong TQ, Silva AC, Lee S-P, Kim S-G. Comparison of spatial localization between synaptic activity and hemodynamic responses following somatosensory stimulation: an MRI study at 9. 4 Tesla. Proc of the ISMRM 7th Scientific Meeting, Philadelphia, 1999. p 378.
34. Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow and Metab. 2007; 27: 196-204.
35. Wu O, Koroshetz WJ, Ostergard L, Buonanno FS, Copen W, Gonzales G, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion-and perfusion-weighted MR imaging. Stroke. 2001; 32: 933-42.
36. Shen Q, Ren H, Fisher M, Duong TQ. Statistical prediction of tissue fates in acute ischemic brain injury. J Cereb Blood Flow and Metab. 2005; 25: 1336-45.
37. Shen Q, Duong TQ. Quantitative prediction of ischemic stroke tissue fate. NMR Biomed. 2008; 21: 839-48.
38. Huang S, Shen Q, Duong TQ. Artificial neural-network prediction of ischemic tissue fate in acute stroke imaging. J Cereb Blood Flow Metab. 2010; 30: 1661-70.
39. Huang S, Shen Q, Duong TQ. Quantitative prediction of acute ischemic tissue fate using support vector machine. Brain Res. 2011; 1405: 77-84.
40. Lassen NA. The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain. Lancet. 1966; 2: 1113-5.
41. Heiss W-D, Graf R, Lottgen J, Ohta K, Fujita T, Wagner R, Grond M, Weinhard K. Repeat positron emission tomographic studies in transient middle cerebral artery occlusion in cats. Journ of cereb blood flow and metab. 1997; 17: 388-400.
42. Kastrup A, Engelhorn T, Beaulieu C, de Crespigny A, Moseley ME. Dynamics of cerebral injury, perfusion, and blood-brain barrier changes after temporary and permanent middle cerebral artery occlusion in the rat. J Neurol Sci. 1999; 166: 91-9.
43. Kidwell CS, Saver JL, Mattiello J, Starkman S, Vinuela F, Duckwiller G, Gobin YP, Jahan R, Vespa JP, Villablanca JP, Liebeskind DS, Woods RP, Alger JR. Diffusion-perfusion MRI characterization of post-recanalization hyperperfusion in humans. Neurology. 2001; 57: 2015-21.
44. Marchal G, Beaudouin V, Rioux P, de la Sayette V, Le Doze F, Viader F, Derlon JM, Baron JC. Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis. Stroke. 1996; 27: 599-606.
45. Sundt Jr TM, Grant WC, Garcia JH. Restoration of middle cerebral artery flow in experimental infarction. J Neurosurg. 1969; 31: 311-21.
46. Tasdemiroglu E, Macfarlane R, Wei EP, Kontos HA, Moskowitz MA. Pial vessel caliber and cerebral blood flow become dissociated during ischemia-reperfusion in cats. Am J Physiol. 1992; 263: H533-536.
47. Marchal G, Furlan M, Beaudouin V, Rioux P, Hauttement JL, Serrati C, de la Sayette V, Le Doze F, Viader F, Derlon JM, Baron JC. Early spontaneous hyperperfusion after stroke. A marker of favourable tissue outcome? Brain. 1996; 119(2): 409-19.
48. Schaller B, Graf R. Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab. 2004; 24: 351-71.
49. Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007; 49: 93-102.
50. Ackerman RH, Correia JA, Alpert NM, Baron JC, Gouliamos A, Grotta JC, Brownell GL, Taveras JM. Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations. Arch Neurol. 1981; 38: 537-43.
51. Baron JC, Bousser MG, Comar D, Soussaline F, Castaigne P. Noninvasive tomographic study of cerebral blood flow and oxygen metabolism in vivo. Potentials, limitations, and clinical applications in cerebral ischemic disorders. Eur Neurol. 1981; 20: 273-84.
52. Baron JC, Delattre JY, Bories J, Chiras J, Cabanis EA, Blas C, Bousser MG, Comar D. Comparison study of CT and positron emission tomographic data in recent cerebral infarction. AJNR Am J Neuroradiol. 1983; 4: 536-40.
53. Tran Dinh YR, Ille O, Guichard JP, Haguenau M, Seylaz J. Cerebral postischemic hyperperfusion assessed by Xenon-133 SPECT. J Nucl Med. 1997; 38: 602-7.
54. Kontos HA, Wei EP. Oxygen-dependent mechanisms in cerebral autoregulation. Ann Biomed Eng. 1985; 13: 329-34.
55. Berne RM, Rubio R. Regulation of coronary blood flow. Adv Cardiol. 1974; 12: 303-17.
56. Joo F. The blood-brain barrier. New aspects to the function of the cerebral endothelium. Nature. 1986; 321: 197-8.
57. Macfarlane R, Moskowitz MA, Sakas DE, Tasdemiroglu E, Wei EP, Kontos HA. The role of neuroeffector mechanisms in cerebral hyperperfusion syndromes. Journal of neurosurgery. 1991; 75: 845-55.
58. Yamaguchi T. Regional cerebral blood flow in experimental cerebral infarction, with special reference to hyperemia in the ischemic cerebral hemisphere. Int J Neurol. 1977; 11: 162-78.
59. Shen Q, Du F, Huang S, Duong TQ. Spatiotemporal characteristics of postischemic hyperperfusion with respect to changes in T1, T2, diffusion, angiography, and blood-brain barrier permeability. J Cereb Blood Flow Metab. 2011; 31: 2076-85.
60. Dani KA, Santosh C, Brennan D, McCabe C, Holmes WM, Condon B, Hadley DM, Macrae IM, Shaw M, Muir KW. T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Ann Neurol. 2010; 68: 37-47.
61. Santosh C, Brennan D, McCabe C, Macrae IM, Holmes WM, Graham DI, Gallagher L, Condon B, Hadley DM, Muir KW, Gsell W. Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. J Cereb Blood Flow Metab. 2008; 28: 1742-53.
62. Ogawa S, Lee TM. Magnetic resonance imaging of blood vessels at high fields: in vivo and in vitro measurements and image simulation. Magn Reson Med. 1990; 16: 9-18.
63. Ogawa S, Menon RS, Tank DW, Kim S-G, Merkle H, Ellermann JM, Ugurbil K. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. Biophys J. 1993; 64: 800-12.
64. Shen Q, Huang S, Du F, Duong TQ. Probing ischemic tissue fate with BOLD fMRI of brief oxygen challenge. Brain Res. 2011; 1425: 132-41.
65. Wey HY, Wang DJ, Duong TQ. Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons. J Cereb Blood Flow Metab. 2010; 31: 715-24.
66. De Crespigny A, D'Arceuil HE, Maynard KL, He J, McAuliffe D, Norbash A, Sahgal PK, Hamberg LM, Hunter GJ, Budzik RF, Putman CM, Gonzalez RG. Acute studies of a new primate model of reversible middle cerebral artery occlusion. J Stroke and Cerebrovas Dis. 2006; 14: 80-8.
67. Tanaka Y, Nagaoka T, Nair G, Ohno K, Duong TQ. Arterial spin labeling and dynamic susceptibility contrast CBF MRI in postischemic hyperperfusion, hypercapnia, and after mannitol injection. J Cereb Blood Flow Metab 2011; 31: 1403-1411.