Critical role of cardiac t-tubule system for the maintenance of contractile function revealed by a 3D integrated model of cardiomyocytes

Journal of Biomechanics

Volumn 45, Issue 5, 2012, Pages 815-823

  Hatano, Asuka ^a   Okada, Jun ichi ^a   Hisada, Toshiaki ^a   Sugiura, Seiryo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Excitation contraction coupling; Finite element methods; Reaction diffusion; Subcellular structure; T tubule

Indexed keywords

3D FINITE ELEMENT MODEL; CARDIAC CONTRACTION; CARDIOMYOCYTES; CAUSAL RELATIONSHIPS; COMPLEX NATURE; COUPLING PROCESS; E-C COUPLING; EXCITATION-CONTRACTION COUPLING; EXPERIMENTAL APPROACHES; EXPERIMENTAL STUDIES; HEART DISEASE; INTEGRATED MODELS; INTRACELLULAR CA; MECHANICAL EQUILIBRIUM; MEMBRANE DEPOLARIZATION; MORPHOLOGICAL CHANGES; MYOFIBRILS; REACTION DIFFUSION; REACTION DIFFUSION EQUATIONS; SARCOPLASMIC RETICULUM; SUB-CELLULAR; SUBCELLULAR COMPONENTS; SUBCELLULAR STRUCTURE; T-TUBULE; VENTRICULAR MYOCYTES;

CARDIOLOGY; ELECTROPHYSIOLOGY; FINITE ELEMENT METHOD; LINEAR EQUATIONS; MAINTAINABILITY; MAMMALS; MATHEMATICAL MODELS;

THREE DIMENSIONAL;

ANIMAL CELL; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; EXCITATION CONTRACTION COUPLING; HEART CONTRACTION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; MATHEMATICAL MODEL; MEMBRANE POTENTIAL; MITOCHONDRION; MORPHOLOGY; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; SARCOMERE; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; THREE DIMENSIONAL IMAGING; TRANSVERSE TUBULAR SYSTEM;

ANIMALS; CALCIUM; CALCIUM SIGNALING; COMPUTER SIMULATION; EXCITATION CONTRACTION COUPLING; GUINEA PIGS; HEART; HEART VENTRICLES; MITOCHONDRIA, HEART; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; SARCOLEMMA; SARCOMERES; SARCOPLASMIC RETICULUM;

EID: 84857655163     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.11.022     Document Type: Article

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