Expression and cellular distribution of vascular endothelial growth factor-C system in cortical tubers of the tuberous sclerosis complex

Brain Pathology

Volumn 22, Issue 2, 2012, Pages 205-218

  Zhang, Chun Qing ^a   Shu, Hai Feng ^a   Yin, Qing ^b   An, Ning ^a   Xu, Sen Lin ^c   Yin, Jin Bo ^a   Song, Ye Chun ^a   Liu, Shi Yong ^a   Yang, Hui ^a  

^a Xinqiao Hospital   (China)

^b SOUTHWEST HOSPITAL   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

cortical tubers; pediatric epilepsy; receptors; tuberous sclerosis complex; vascular endothelial growth factor C

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAD; PROTEIN KINASE B; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ARTICLE; CELLULAR DISTRIBUTION; CHILD; CONTROLLED STUDY; CORTICAL DYSPLASIA; CORTICAL TUBER; FEMALE; HUMAN; HUMAN TISSUE; MALE; PATHOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUBEROUS SCLEROSIS; UPREGULATION;

BRAIN NEOPLASMS; CEREBRAL CORTEX; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; SIGNAL TRANSDUCTION; TUBEROUS SCLEROSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84857654909     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2011.00519.x     Document Type: Article

References (54)

1. Aprelikova O, Pajusola K, Partanen J, Armstrong E, Alitalo R, Bailey SK, et al, (1992) FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter. Cancer Res 52: 746-748.
2. Boer K, Jansen F, Nellist M, Redeker S, van den Ouweland AM, Spliet WG, et al, (2008) Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. Epilepsy Res 78: 7-21.
3. Boer K, Troost D, Spliet WG, van Rijen PC, Gorter JA, Aronica E, (2008) Cellular distribution of vascular endothelial growth factor A (VEGFA) and B (VEGFB) and VEGF receptors 1 and 2 in focal cortical dysplasia type IIB. Acta Neuropathol 115: 683-696.
4. Boer K, Lucassen PJ, Spliet WG, Vreugdenhil E, van Rijen PC, Troost D, et al, (2009) Doublecortin-like (DCL) expression in focal cortical dysplasia and cortical tubers. Epilepsia 50: 2629-2637.
5. Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, et al, (2006) Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 65: 26-36.
6. Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin WG, Jr, (2003) TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 4: 147-158.
7. Choi JS, Shin YJ, Lee JY, Yun H, Cha JH, Choi JY, et al, (2010) Expression of vascular endothelial growth factor receptor-3 mRNA in the rat developing forebrain and retina. J Comp Neurol 518: 1064-1081.
8. Crino PB, Trojanowski JQ, Dichter MA, Eberwine J, (1996) Embryonic neuronal markers in tuberous sclerosis: single-cell molecular pathology. Proc Natl Acad Sci USA 93: 14152-14157.
9. Crino PB, Nathanson KL, Henske EP, (2006) The tuberous sclerosis complex. N Engl J Med 355: 1345-1356.
10. Croll SD, Goodman JH, Scharfman HE, (2004) Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword. Adv Exp Med Biol 548: 57-68.
11. Dias S, Choy M, Alitalo K, Rafii S, (2002) Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 99: 2179-2184.
12. Duronio V, (2008) The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 415: 333-344.
13. El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ, (2003) Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 63: 5173-5177.
14. Engel J Jr, Van Ness PC, Rasmussen TB, Ojemann LM, (1993) Outcome with respect to epileptic seizures. In: Surgical Treatment of the Epilepsies., J Engel Jr, (ed.), pp. 609-621. Raven Press: NewYork.
15. Fauser S, Becker A, Schulze-Bonhage A, Hildebrandt M, Tuxhorn I, Pannek HW, et al, (2004) CD34-immunoreactive balloon cells in cortical malformations. Acta Neuropathol 108: 272-278.
16. Foldi M, (1996) The brain and the lymphatic system (II). Lymphology 29: 10-14.
17. Gollmer JC, Ladoux A, Gioanni J, Paquis P, Dubreuil A, Chatel M, Frelin C, (2000) Expression of vascular endothelial growth factor-b in human astrocytoma. Neuro Oncol 2: 80-86.
18. Grau SJ, Trillsch F, Herms J, Thon N, Nelson PJ, Tonn JC, Goldbrunner R, (2007) Expression of VEGFR3 in glioma endothelium correlates with tumor grade. J Neurooncol 82: 141-150.
19. Hlobilkova A, Ehrmann J, Knizetova P, Krejci V, Kalita O, Kolar Z, (2009) Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression. Neoplasma 56: 284-290.
20. Huber H, Eggert A, Janss AJ, Wiewrodt R, Zhao H, Sutton LN, et al, (2001) Angiogenic profile of childhood primitive neuroectodermal brain tumours/medulloblastomas. Eur J Cancer 37: 2064-2072.
21. Hynd MR, Lewohl JM, Scott HL, Dodd PR, (2003) Biochemical and molecular studies using human autopsy brain tissue. J Neurochem 85: 543-562.
22. Issa R, Krupinski J, Bujny T, Kumar S, Kaluza J, Kumar P, (1999) Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke. Lab Invest 79: 417-425.
23. Jenny B, Harrison JA, Baetens D, Tille JC, Burkhardt K, Mottaz H, et al, (2006) Expression and localization of VEGF-C and VEGFR-3 in glioblastomas and haemangioblastomas. J Pathol 209: 34-43.
24. Ji RC, (2007) Lymphatic endothelial cells, inflammatory lymphangiogenesis, and prospective players. Curr Med Chem 14: 2359-2368.
25. Jozwiak J, Jozwiak S, Skopinski P, (2005) Immunohistochemical and microscopic studies on giant cells in tuberous sclerosis. Histol Histopathol 20: 1321-1326.
26. Kranich S, Hattermann K, Specht A, Lucius R, Mentlein R, (2009) VEGFR-3/Flt-4 mediates proliferation and chemotaxis in glial precursor cells. Neurochem Int 55: 747-753.
27. Krum JM, Mani N, Rosenstein JM, (2008) Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury. Exp Neurol 212: 108-117.
28. Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, et al, (2006) VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat Neurosci 9: 340-348.
29. Liu S, An N, Yang H, Yang M, Hou Z, Liu L, Liu Y, (2007) Pediatric intractable epilepsy syndromes: reason for early surgical intervention. Brain Dev 29: 69-78.
30. Luat AF, Makki M, Chugani HT, (2007) Neuroimaging in tuberous sclerosis complex. Curr Opin Neurol 20: 142-150.
31. Ma YH, Mentlein R, Knerlich F, Kruse ML, Mehdorn HM, Held-Feindt J, (2008) Expression of stem cell markers in human astrocytomas of different WHO grades. J Neurooncol 86: 31-45.
32. Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, et al, (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med 15: 545-552.
33. Maurer MH, Tripps WK, Feldmann RE Jr, Kuschinsky W, (2003) Expression of vascular endothelial growth factor and its receptors in rat neural stem cells. Neurosci Lett 344: 165-168.
34. Mizuguchi M, Takashima S, (2001) Neuropathology of tuberous sclerosis. Brain Dev 23: 508-515.
35. Napolioni V, Moavero R, Curatolo P, (2009) Recent advances in neurobiology of Tuberous Sclerosis Complex. Brain Dev 31: 104-113.
36. Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K, (1992) FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res 52: 5738-5743.
37. Parker WE, Orlova KA, Heuer GG, Baybis M, Aronica E, Frost M, et al, (2011) Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex. Am J Pathol 178: 296-305.
38. Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee WK, Wiestler OD, (1997) Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol 93: 109-117.
39. Raab S, Plate KH, (2007) Different networks, common growth factors: shared growth factors and receptors of the vascular and the nervous system. Acta Neuropathol 113: 607-626.
40. Ravizza T, Boer K, Redeker S, Spliet WG, van Rijen PC, Troost D, et al, (2006) The IL-1beta system in epilepsy-associated malformations of cortical development. Neurobiol Dis 24: 128-143.
41. Rigau V, Morin M, Rousset MC, de Bock F, Lebrun A, Coubes P, et al, (2007) Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain 130: 1942-1956.
42. Rodgers KM, Hutchinson MR, Northcutt A, Maier SF, Watkins LR, Barth DS, (2009) The cortical innate immune response increases local neuronal excitability leading to seizures. Brain 132: 2478-2486.
43. Salameh A, Galvagni F, Bardelli M, Bussolino F, Oliviero S, (2005) Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. Blood 106: 3423-3431.
44. Salven P, Mustjoki S, Alitalo R, Alitalo K, Rafii S, (2003) VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood 101: 168-172.
45. Schick V, Majores M, Engels G, Hartmann W, Elger CE, Schramm J, et al, (2007) Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells. Brain Pathol 17: 165-173.
46. Shin YJ, Choi JS, Lee JY, Choi JY, Cha JH, Chun MH, Lee MY, (2008) Differential regulation of vascular endothelial growth factor-C and its receptor in the rat hippocampus following transient forebrain ischemia. Acta Neuropathol 116: 517-527.
47. Shin YJ, Choi JS, Choi JY, Cha JH, Chun MH, Lee MY, (2010) Enhanced expression of vascular endothelial growth factor receptor-3 in the subventricular zone of stroke-lesioned rats. Neurosci Lett 469: 194-198.
48. Shin YJ, Choi JS, Choi JY, Hou Y, Cha JH, Chun MH, Lee MY, (2010) Induction of vascular endothelial growth factor receptor-3 mRNA in glial cells following focal cerebral ischemia in rats. J Neuroimmunol 229: 81-90.
49. Simiantonaki N, Jayasinghe C, Michel-Schmidt R, Peters K, Hermanns MI, Kirkpatrick CJ, (2008) Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines. Int J Oncol 32: 585-592.
50. Storkebaum E, Carmeliet P, (2004) VEGF: a critical player in neurodegeneration. J Clin Invest 113: 14-18.
51. Croll SD, Ransohoff RM, Caia N, Zhanga Q, Martina FJ, Weib T, et al, (2004) VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol 187: 388-402.
52. van Vliet EA, Araujo S, Redeker S, van Schaik R, Aronica E, Gorter JA, (2007) Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 130 (Pt 2): 521-534.
53. Vezzani A, (2005) VEGF and seizures: cross-talk between endothelial and neuronal environments. Epilepsy Curr 5: 72-74.
54. Vezzani A, Granata T, (2005) Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46: 1724-1743.