Hyaluronan receptors in the human ocular surface: A descriptive and comparative study of RHAMM and CD44 in tissues, cell lines and freshly collected samples

Histochemistry and Cell Biology

Volumn 137, Issue 2, 2012, Pages 165-176

  García Posadas, Laura ^a,b   Contreras Ruiz, Laura ^a,b   López García, Antonio ^a,b   Villarón Álvarez, Sonia ^a   Maldonado, Miguel J ^a   Diebold, Yolanda ^a,b  

^a UNIVERSITY OF VALLADOLID   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

CD44; Conjunctiva; Epithelial cells; Eye; Hyaluronan receptors; Inflammation; Ocular surface; RHAMM

Indexed keywords

CD44V ANTIGEN; HYALURONAN RECEPTOR; MESSENGER RNA; RECEPTOR; RECEPTOR FOR HYALURONAN MEDIATED MOTILITY; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL LINE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CORNEA EPITHELIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; LACRIMAL FLUID; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIGENS, CD44; CELLS, CULTURED; CONJUNCTIVA; CONJUNCTIVITIS; CORNEA; EPITHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; KERATITIS; RNA, MESSENGER; TEARS;

EID: 84857638712     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-011-0878-z     Document Type: Article

References (41)

1. V Abetamann HF Kern HP Elsasser 1996 Differential expression of the hyaluronan receptors CD44 and RHAMM in human pancreatic cancer cells Clin Cancer Res 2 1607 1618 9816340 1:STN:280:DyaK1M%2FjsFWrug%3D%3D (Pubitemid 126447457)
2. S Ahmad S Kolli DQ Li CS de Paiva S Pryzborski I Dimmick L Armstrong FC Figueiredo M Lako 2008 A putative role for RHAMM/HMMR as a negative marker of stem cell-containing population of human limbal epithelial cells Stem Cells 26 1609 1619 18356573 10.1634/stemcells.2007-0782 1:CAS:528:DC%2BD1cXotFGhur8%3D
3. K Araki-Sasaki Y Ohashi T Sasabe K Hayashi H Watanabe Y Tano H Handa 1995 An SV40-immortalized human corneal epithelial cell line and its characterization Invest Ophthalmol Vis Sci 36 614 621 7534282 1:STN:280:DyaK2M7psleltw%3D%3D
4. A Aruffo I Stamenkovic M Melnick CB Underhill B Seed 1990 CD44 is the principal cell surface receptor for hyaluronate Cell 61 1303 1313 1694723 10.1016/0092-8674(90)90694-A 1:CAS:528:DyaK3cXkslGgtbc%3D (Pubitemid 20208834)
5. V Assmann D Jenkinson JF Marshall IR Hart 1999 The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments J Cell Sci 112 Pt 22 3943 3954 10547355 1:CAS:528:DyaK1MXotV2lt7k%3D (Pubitemid 30119764)
6. YU Budak M Akdogan K Huysal 2009 Aqueous humor level of sCD44 in patients with degenerative myopia and primary open-angle glaucoma BMC Research Notes 2 224 19895708 10.1186/1756-0500-2-224
7. Y Buganim V Rotter 2008 RHAMM in the complex p53 cell cycle network Cell Cycle 7 21 10.4161/cc.7.21.7256
8. J Cichy E Puré 2003 The liberation of CD44 J Cell Biol 161 839 843 12796473 10.1083/jcb.200302098 1:CAS:528:DC%2BD3sXks1Gmu7g%3D (Pubitemid 36718417)
9. L Contreras-Ruiz FM De la JE Parraga A Lopez-Garcia I Fernandez B Seijo A Sanchez M Calonge Y Diebold 2011 Intracellular trafficking of hyaluronic acid-chitosan oligomer-based nanoparticles in cultured human ocular surface cells Mol Vis 17 279 290 21283563 1:CAS:528:DC%2BC3MXit1Cgu7o%3D
10. M De la Fuente B Seijo MJ Alonso 2008 Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy Invest Ophthalmol Vis Sci 49 2016 2024 18436835 10.1167/iovs.07-1077
11. JM De Saint C Baudouin NM Di S Roman P Lozato JM Warnet F Brignole 2004 Comparison of morphological and functional characteristics of primary-cultured human conjunctival epithelium and of Wong-Kilbourne derivative of Chang conjunctival cell line Exp Eye Res 78 257 274 10.1016/j.exer.2003.10.006 (Pubitemid 38077232)
12. Y Diebold M Calonge S Callejo Enriquez-de-Salamanca RM Corrales V Saez KF Siemasko ME Stern 2003 Characterization of a spontaneously immortalized cell line (IOBA-NHC) from normal human conjunctiva Invest Ophthalmol Vis Sci 44 4263 4274 14507870 10.1167/iovs.03-0560 (Pubitemid 37186260)
13. A Enriquez-de-Salamanca V Calder J Gao G Galatowicz C Garcia-Vazquez I Fernandez ME Stern Y Diebold M Calonge 2008 Cytokine responses by conjunctival epithelial cells: an in vitro model of ocular inflammation Cytokine 44 160 167 18760623 10.1016/j.cyto.2008.07.007 1:CAS:528:DC%2BD1cXhtFOmtrbM
14. A Enriquez-de-Salamanca E Castellanos ME Stern I Fernández E Carreño C García-Vázquez JM Herreras M Calonge 2010 Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease Mol Vis 16 862 873 20508732 1:CAS:528:DC%2BC3cXmslaju74%3D
15. J Entwistle CL Hall EA Turley 1996 HA receptors: regulators of signalling to the cytoskeleton J Cell Biochem 61 569 577 8806080 10.1002/(SICI)1097- 4644(19960616)61:4<569::AID-JCB10>3.0.CO;2-B 1:CAS:528:DyaK28Xkt1Wqu7g%3D (Pubitemid 26240134)
16. EJ Franzmann EP Reategui KL Carraway KL Hamilton DT Weed WJ Goodwin 2005 Salivary soluble CD444: a potential molecular marker for head and neck cancer Cancer Epidemiol Biomarkers Prev 14 735 739 15767360 10.1158/1055-9965.EPI-04- 0546 1:CAS:528:DC%2BD2MXit1Kgurc%3D (Pubitemid 40489225)
17. T Fujihara T Takeuchi K Saito K Tsubota 1997 Flow cytometric analysis of surface antigens on human conjunctival epithelial cells Ophthalmic Res 29 103 109 9154536 10.1159/000268003 1:CAS:528:DyaK2sXjtFSlsbc%3D (Pubitemid 27197048)
18. KM Gust MD Hofer SR Perner R Kim AM Chinnaiyan S Varambally P Moller L Rinnab MA Rubin J Greiner M Schmitt R Kuefer M Ringhoffer 2009 RHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease Neoplasia 11 956 963 19724689 1:CAS:528:DC%2BD1MXhtVKht7jE
19. SR Hamilton SF Fard FF Paiwand C Tolg M Veiseh C Wang JB McCarthy MJ Bissell J Koropatnick EA Turley 2007 The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1, 2 that sustain high basal motility in breast cancer cells J Biol Chem 282 16667 16680 17392272 10.1074/jbc.M702078200 1:CAS:528:DC%2BD2sXlvVajurg%3D (Pubitemid 47100370)
20. C Hardwick K Hoare R Owens HP Hohn M Hook D Moore V Cripps L Austen DM Nance EA Turley 1992 Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility J Cell Biol 117 1343 1350 1376732 10.1083/jcb.117.6.1343 1:CAS:528:DyaK3sXhs1Kht7c%3D
21. M Hornof FM de la M Hallikainen RH Tammi A Urtti 2008 Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells J Gene Med 10 70 80 18044795 10.1002/jgm.1125 1:CAS:528:DC%2BD1cXitFWhsLk%3D
22. JL Hughes PM Lackie SJ Wilson MK Church JI McGill 2006 Reduced structural proteins in the conjunctival epithelium in allergic eye disease Allergy 61 1268 1274 17002701 10.1111/j.1398-9995.2006.01207.x 1:CAS:528:DC%2BD28Xht1OjurbO (Pubitemid 44465585)
23. CM Isacke H Yarwood 2002 The hyaluronan receptor, CD44 Int J Biochem Cell Biol 34 718 721 11950588 10.1016/S1357-2725(01)00166-2 1:CAS:528: DC%2BD38Xis1CqtLk%3D (Pubitemid 34304161)
24. U Laemmli 1970 Cleavage of structural proteins during assembly of the head of bacteriophage T4 Nature 227 680 685 5432063 10.1038/227680a0 1:CAS:528:DC%2BD3MXlsFags7s%3D
25. LE Lerner DM Schwartz DG Hwang EL Howes R Stern 1998 Hyaluronan and CD44 in the human cornea and limbal conjunctiva Exp Eye Res 67 481 484 9820796 10.1006/exer.1998.0567 1:CAS:528:DyaK1MXisFai (Pubitemid 28552970)
26. KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 402 408 11846609 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D (Pubitemid 34164012)
27. CA Maxwell J McCarthy E Turley 2008 Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions? J Cell Sci 121 925 932 18354082 10.1242/jcs.022038 1:CAS:528:DC%2BD1cXlsF2nsLk%3D (Pubitemid 351639411)
28. D Naor RV Sionov D Ish-Shalom 1997 CD44: structure, function, and association with the malignant process Adv Cancer Res 71 241 319 9111868 10.1016/S0065-230X(08)60101-3 1:CAS:528:DyaK2sXjvVOkurs%3D (Pubitemid 27197761)
29. S Nedvetzki E Gonen N Assayag R Reich RO Williams RL Thurmond JF Huang BA Neudecker FS Wang EA Turley D Naor 2004 RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy Proc Natl Acad Sci USA 101 18081 18086 15596723 10.1073/pnas.0407378102 1:CAS:528:DC%2BD2MXjsl2msA%3D%3D (Pubitemid 40054077)
30. LM Pilarski A Masellis-Smith AR Belch B Yang RC Savani EA Turley 1994 RHAMM, a receptor for hyaluronan-mediated motility, on normal human lymphocytes, thymocytes and malignant B cells: a mediator in B cell malignancy? Leuk Lymphoma 14 363 374 7529076 10.3109/10428199409049691 1:STN:280: DyaK2M7htFentw%3D%3D
31. L Sherman J Sleeman P Herrlich H Ponta 1994 Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression Curr Opin Cell Biol 6 726 733 7530464 10.1016/0955-0674(94)90100-7 1:CAS:528: DyaK2cXmsFalsr4%3D (Pubitemid 24295307)
32. M Slevin J Krupinski J Gaffney S Matou D West H Delisser RC Savani S Kumar 2007 Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways Matrix Biol 26 58 68 17055233 10.1016/j.matbio.2006.08.261 1:CAS:528:DC%2BD2sXmtVCiug%3D%3D (Pubitemid 46091650)
33. RJ Sneath DC Mangham 1998 The normal structure and function of CD44 and its role in neoplasia Mol Pathol 51 191 200 9893744 10.1136/mp.51.4.191 1:CAS:528:DyaK1cXmtVyht7o%3D (Pubitemid 28394267)
34. S Sohr K Engeland 2008 RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53 Cell Cycle 7 3448 3460 18971636 10.4161/cc.7.21.7014 1:CAS:528:DC%2BD1cXhsFWgtLrK
35. H Towbin T Staehelin J Gordon 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc Natl Acad Sci 76 4350 4354 388439 10.1073/pnas.76.9.4350 1:CAS:528:DyaE1MXmtVKltLw%3D (Pubitemid 9256559)
36. EA Turley 1982 Purification of a hyaluronate-binding protein fraction that modifies cell social behavior Biochem Biophys Res Commun 108 1016 1024 6185115 10.1016/0006-291X(82)92101-5 1:CAS:528:DyaL38XlsF2ru70%3D (Pubitemid 13072654)
37. EA Turley L Austen K Vandeligt C Clary 1991 Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells J Cell Biol 112 1041 1047 1705559 10.1083/jcb.112.5.1041 1:CAS:528:DyaK3MXnvFCnug%3D%3D (Pubitemid 21909648)
38. EA Turley PW Noble LY Bourguignon 2002 Signaling properties of hyaluronan receptors J Biol Chem 277 4589 4592 11717317 10.1074/jbc.R100038200 1:CAS:528:DC%2BD38XhsFeqsbo%3D (Pubitemid 34968484)
39. C Underhill 1992 CD44: the hyaluronan receptor J Cell Sci 103 Pt 2 293 298 1282514 1:CAS:528:DyaK3sXitVOmurs%3D
40. FX Yu J Guo Q Zhang 1998 Expression and distribution of adhesion molecule CD44 in healing corneal epithelia Invest Ophthalmol Vis Sci 39 710 717 9538877 1:STN:280:DyaK1c7pvFOjsQ%3D%3D (Pubitemid 28207465)
41. SN Zhu B Nolle G Duncker 1997 Expression of adhesion molecule CD44 on human corneas Br J Ophthalmol 81 80 84 9135415 10.1136/bjo.81.1.80 1:STN:280:DyaK2s3otFWjtQ%3D%3D