Epinephrine and the metabolic syndrome

Current Hypertension Reports

Volumn 14, Issue 1, 2012, Pages 1-7

  Ziegler, Michael G ^a   Elayan, Hamzeh ^b   Milic, Milos ^c   Sun, Ping ^c   Gharaibeh, Munir ^b  

^a UCSD MEDICAL CENTER   (United States)

^b UNIVERSITY OF JORDAN   (Jordan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Beta adrenergic receptors; Blood pressure; Diabetes; Epinephrine; Exercise; Glucose; Hypertension; Insulin; Metabolic syndrome; Norepinephrine; Obesity; Stress

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; CLENBUTEROL; GLUCOSE; INSULIN; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ADRENALIN DEFICIENCY; ADRENALIN RELEASE; AGING; ARTICLE; BETA ADRENERGIC STIMULATION; BLOOD VESSEL REACTIVITY; DISEASE SEVERITY; EXERCISE; FAT INTAKE; GENOTYPE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HEART HYPERTROPHY; HEART OUTPUT; HEART STRESS; HEART STROKE VOLUME; HORMONE ACTION; HORMONE DEFICIENCY; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; METABOLIC SYNDROME X; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OVERNUTRITION; PATHOGENESIS; PRESSOR RESPONSE; PROTEIN FUNCTION; SYSTOLIC BLOOD PRESSURE; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATATION;

ADRENERGIC AGONISTS; ANIMALS; CARDIOVASCULAR SYSTEM; DIETARY FATS; DISEASE MODELS, ANIMAL; EPINEPHRINE; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; METABOLIC SYNDROME X; MICE; MICE, TRANSGENIC; RECEPTORS, ADRENERGIC; STRESS, PHYSIOLOGICAL; VASODILATION;

EID: 84857631461     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-011-0243-6     Document Type: Article

References (52)

1. SN Ebert Q Rong S Boe RP Thompson A Grinberg K Pfeifer 2004 Targeted insertion of the Cre-recombinase gene at the phenylethanolamine n-methyltransferase locus: a new model for studying the developmental distribution of adrenergic cells Dev Dyn. 231 849 58 15517585 10.1002/dvdy.20188 1:CAS:528:DC%2BD2cXhtFakur3J
2. B Kennedy MG Ziegler 1991 Cardiac epinephrine synthesis. Regulation by a glucocorticoid Circulation. 84 891 5 1860230 1:CAS:528:DyaK3MXmt1Cgsb4%3D
3. WE Clutter DM Bier SD Shah PE Cryer 1980 Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man J Clin Invest. 66 94 101 6995479 10.1172/JCI109840 1:CAS:528: DyaL3cXltVOrtr4%3D
4. M Kjaer K Howlett J Langfort T Zimmerman-Belsing J Lorentsen J Bulow J Ihlemann U Feldt-Rasmussen H Galbo 2000 Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans J Physiol. 528 Pt 2 371 8 11034626 10.1111/j.1469-7793.2000.00371.x 1:CAS:528: DC%2BD3cXnvVSht78%3D
5. E Ashkar 1971 Cardiovascular effects of adrenal medullectomy in dogs during rest and exercise Acta Physiol Lat Am. 20 299 307 5099130 1:STN:280:DyaE38%2FhtlKktw%3D%3D
6. C Harakal MM Reidenberg RW Sevy EA Ohler 1966 Hemodynamic effects of adrenal medullectomy in the dog Am J Physiol. 210 5 6 5903145 1:STN:280:DyaF28%2Fnslemtg%3D%3D
7. B Kennedy TD Bigby MG Ziegler 1995 Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels J Clin Invest. 95 2896 902 7769131 10.1172/JCI117996 1:CAS:528:DyaK2MXmtV2qtrY%3D
8. X Bao CM Lu F Liu Y Gu ND Dalton BQ Zhu E Foster J Chen JS Karliner J Ross Jr PC Simpson MG Ziegler 2007 Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse Circulation. 116 1024 31 17698731 10.1161/CIRCULATIONAHA.107. 696005 1:CAS:528:DC%2BD2sXpt1Gmt7k%3D
9. B Tidgren P Hjemdahl E Theodorsson J Nussberger 1991 Renal neurohormonal and vascular responses to dynamic exercise in humans J Appl Physiol. 70 2279 86 1677937 1:CAS:528:DyaK3MXlt1yisrs%3D
10. O Celander 1954 The range of control exercised by the sympathico-adrenal system; a quantitative study on blood vessels and other smooth muscle effectors in the cat Acta Physiol Scand Suppl. 32 1 132 13206802 10.1111/j.1748-1716.1954. tb01150.x 1:CAS:528:DyaG2MXisFSlsQ%3D%3D
11. AJ Chruscinski DK Rohrer E Schauble KH Desai D Bernstein BK Kobilka 1999 Targeted disruption of the beta2 adrenergic receptor gene J Biol Chem. 274 16694 700 10358008 10.1074/jbc.274.24.16694 1:CAS:528:DyaK1MXjvVGksLk%3D
12. JP Singh MG Larson TA Manolio CJ O'Donnell M Lauer JC Evans D Levy 1999 Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham heart study Circulation. 99 1831 6 10199879 1:STN:280:DyaK1M3hs1eksA%3D%3D
13. G Seematter C Binnert L Tappy 2005 Stress and metabolism Metab Syndr Relat Disord. 3 8 13 18370704 10.1089/met.2005.3.8 1:STN:280: DC%2BD1c3ht1eqtw%3D%3D
14. Selye H. The stress of life. 2nd ed. New York: McGraw-Hill; 1976.
15. SE Kjeldsen I Eide I Aakesson P Leren 1983 Influence of body weight on plasma catecholamine patterns in middle-aged, normotensive men Scand J Clin Lab Invest. 43 339 42 6635540 10.3109/00365518309168268 1:CAS:528:DyaL3sXks1Crt7c%3D
16. PA Tataranni JB Young C Bogardus E Ravussin 1997 A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men Obes Res. 5 341 7 9285842 1:STN:280: DyaK2svjtFyjtw%3D%3D
17. ML Tuck 1992 Obesity, the sympathetic nervous system, and essential hypertension Hypertension. 19 I67 77 1730457 1:STN:280:DyaK387ht1alug%3D%3D
18. JB Young RJ Troisi ST Weiss DR Parker D Sparrow L Landsberg 1992 Relationship of catecholamine excretion to body size, obesity, and nutrient intake in middle-aged and elderly men Am J Clin Nutr. 56 827 34 1415000 1:CAS:528:DyaK3sXhs1Oguw%3D%3D
19. Y Schutz T Bessard E Jequier 1984 Diet-induced thermogenesis measured over a whole day in obese and nonobese women Am J Clin Nutr. 40 542 52 6540980 1:STN:280:DyaL2czgtl2qsg%3D%3D
20. RS Schwartz LF Jaeger RC Veith 1987 The importance of body composition to the increase in plasma norepinephrine appearance rate in elderly men J Gerontol. 42 546 51 3114359 1:STN:280:DyaL2szgvFKiug%3D%3D
21. AD Baron P Wallace JM Olefsky 1987 In vivo regulation of non-insulin-mediated and insulin-mediated glucose uptake by epinephrine J Clin Endocrinol Metab. 64 889 95 2881942 10.1210/jcem-64-5-889 1:CAS:528: DyaL2sXitVygsr0%3D
22. HO Lithell 1991 Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism Diabetes Care. 14 203 9 1828417 10.2337/diacare.14.3.203 1:STN:280:DyaK3M3ls1ymsQ%3D%3D
23. ZS Lee JA Critchley B Tomlinson RP Young GN Thomas CS Cockram TY Chan JC Chan 2001 Urinary epinephrine and norepinephrine interrelations with obesity, insulin, and the metabolic syndrome in Hong Kong Chinese Metabolism. 50 135 43 11229419 10.1053/meta.2001.19502 1:CAS:528:DC%2BD3MXhtFSqtbs%3D
24. KD Ward D Sparrow L Landsberg JB Young PS Vokonas ST Weiss 1994 The relationship of epinephrine excretion to serum lipid levels: the Normative Aging Study Metabolism. 43 509 13 8159112 10.1016/0026-0495(94)90085-X 1:CAS:528:DyaK2cXhvVelu7c%3D
25. RJ Troisi ST Weiss DR Parker D Sparrow JB Young L Landsberg 1991 Relation of obesity and diet to sympathetic nervous system activity Hypertension. 17 669 77 2022410 1:STN:280:DyaK3M3hs1KjsA%3D%3D
26. J Jensen J Ruzzin E Jebens EO Brennesvik S Knardahl 2005 Improved insulin-stimulated glucose uptake and glycogen synthase activation in rat skeletal muscles after adrenaline infusion: role of glycogen content and PKB phosphorylation Acta Physiol Scand. 184 121 30 15916672 10.1111/j.1365-201X. 2005.01437.x 1:CAS:528:DC%2BD2MXkvVajs7c%3D
27. X Bao PJ Mills BK Rana JE Dimsdale NJ Schork DW Smith F Rao M Milic DT O'Connor MG Ziegler 2005 Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function Hypertension. 46 301 7 16027244 10.1161/01.HYP.0000175842.19266.95 1:CAS:528:DC%2BD2MXmtlSisrc%3D
28. Loomba R, Rao F, Zhang L, Khandrika S, Ziegler MG, Brenner DA, O'Connor DT. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Gastroenterology. 2010; 139:836-45, 845 e1.
29. DR Seals MD Esler 2000 Human ageing and the sympathoadrenal system J Physiol. 528 407 17 11060120 10.1111/j.1469-7793.2000.00407.x 1:CAS:528:DC%2BD3cXot1Ghsrs%3D
30. MW Bowie PW Slattum 2007 Pharmacodynamics in older adults: a review Am J Geriatr Pharmacother. 5 263 303 17996666 10.1016/j.amjopharm.2007.10.001 1:CAS:528:DC%2BD2sXhtlCqtr7K
31. JR Docherty 2002 Age-related changes in adrenergic neuroeffector transmission Auton Neurosci. 96 8 12 11911505 10.1016/S1566-0702(01)00375-7 1:CAS:528:DC%2BD3sXhtVOks70%3D
32. • Ziegler MG, Milic M, Sun P, Tang CM, Elayan H, Bao X, Cheung WW, O'Connor DT. Endogenous epinephrine protects against obesity induced insulin resistance. Auton Neurosci. 2011; 162:32-4. PNMT knockout mice developed worse diabetes.
33. • Marques CM, Motta VF, Torres TS, Aguila MB, Mandarim-de-Lacerda CA. Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice. Braz J Med Biol Res. 2010; 43:467-75. Exercise prevented diabetes in young mice.
34. Ringseis R, Mooren FC, Keller J, Couturier A, Wen G, Hirche F, Stangl GI, Eder K. Kruger K. Mol Nutr Food Res: Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet; 2011.
35. GR Steinberg SB Jorgensen 2007 The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity Mini Rev Med Chem. 7 519 26 17504187 10.2174/138955707780619662 1:CAS:528: DC%2BD2sXlvFGmsb0%3D
36. M Kelly MS Gauthier AK Saha NB Ruderman 2009 Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization Diabetes. 58 1953 60 19502419 10.2337/db08-1293 1:CAS:528:DC%2BD1MXhtFChsbnN
37. S Miura K Kawanaka Y Kai M Tamura M Goto T Shiuchi Y Minokoshi O Ezaki 2007 An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation Endocrinology. 148 3441 8 17446185 10.1210/en.2006-1646 1:CAS:528:DC%2BD2sXntVOnsL8%3D
38. DM Kirsch M Baumgarten T Deufel F Rinninger W Kemmler HU Haring 1983 Catecholamine-induced insulin resistance of glucose transport in isolated rat adipocytes Biochem J. 216 737 45 6667264 1:CAS:528:DyaL2cXhtFyh
39. AH Mulder CJ Tack AJ Olthaar P Smits FC Sweep RR Bosch 2005 Adrenergic receptor stimulation attenuates insulin-stimulated glucose uptake in 3 T3-L1 adipocytes by inhibiting GLUT4 translocation Am J Physiol Endocrinol Metab. 289 E627 33 15914506 10.1152/ajpendo.00079.2004 1:CAS:528:DC%2BD2MXhtFens7fP
40. C Chakraborty 2006 Biochemical and molecular basis of insulin resistance Curr Protein Pept Sci. 7 113 21 16611137 10.2174/138920306776359759 1:CAS:528:DC%2BD28XjsVCgtbs%3D
41. C Sanz JF Gautier H Hanaire 2010 Physical exercise for the prevention and treatment of type 2 diabetes Diabetes Metab. 36 346 51 20675173 10.1016/j.diabet.2010.06.001 1:STN:280:DC%2BC3cbot1aisg%3D%3D
42. TH Marwick MD Hordern T Miller DA Chyun AG Bertoni RS Blumenthal G Philippides A Rocchini 2009 Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association Circulation. 119 3244 62 19506108 10.1161/CIRCULATIONAHA.109.192521
43. JM Gill 2007 Physical activity, cardiorespiratory fitness and insulin resistance: a short update Curr Opin Lipidol. 18 47 52 17218832 10.1097/MOL.0b013e328012b8bd 1:CAS:528:DC%2BD2sXjvFOjsQ%3D%3D
44. PM Haram OJ Kemi SJ Lee MO Bendheim QY Al-Share HL Waldum LJ Gilligan LG Koch SL Britton SM Najjar U Wisloff 2009 Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity Cardiovasc Res. 81 723 32 19047339 10.1093/cvr/cvn332 1:CAS:528:DC%2BD1MXhvF2gsbo%3D
45. DR Rutledge JD Steinberg 1991 Effect of age on lymphocyte beta 2-adrenergic responsiveness DICP. 25 532 8 1648847 1:STN:280: DyaK3M3pslyrtA%3D%3D
46. RP Ebstein J Stessman R Eliakim J Menczel 1985 The effect of age on beta-adrenergic function in man: a review Isr J Med Sci. 21 302 11 2987155 1:STN:280:DyaL2M3gs1yktw%3D%3D
47. N Begin-Heick 1996 Beta-adrenergic receptors and G-proteins in the ob/ob mouse Int J Obes Relat Metab Disord. 20 Suppl 3 S32 5 8680474 1:CAS:528:DyaK28XjtV2gsro%3D
48. • Umpierre D, Ribeiro PA, Kramer CK, Leitao CB, Zucatti AT, Azevedo MJ, Gross JL, Ribeiro JP, Schaan BD. Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. JAMA. 2011; 305:1790-9. The effect of exercise on diabetes in older diabetics.
49. KE Innes HK Vincent AG Taylor 2007 Chronic stress and insulin resistance-related indices of cardiovascular disease risk, part I: neurophysiological responses and pathological sequelae Altern Ther Health Med. 13 46 52 17658122
50. P Weidmann M de Courten L Boehlen S Shaw 1993 The pathogenesis of hypertension in obese subjects Drugs. 46 Suppl 2 197 208 7512475 10.2165/00003495-199300462-00030 discussion 208-9
51. A Moan IK Eide SE Kjeldsen 1996 Metabolic and adrenergic characteristics of young men with insulin resistance Blood Press Suppl. 1 30 7 9162435 1:STN:280:DyaK2s%2Fhtlanug%3D%3D
52. J Zhang R Niaura JR Dyer BJ Shen JF Todaro JM McCaffery A Spiro 3rd KD Ward 2006 Hostility and urine norepinephrine interact to predict insulin resistance: the VA Normative Aging Study Psychosom Med. 68 718 26 17012525 10.1097/01.psy.0000228343.89466.11 1:CAS:528:DC%2BD28XpvVOhs7c%3D