Novel and enantioselective syntheses of (R)- and (S)-3-hydroxy-4-(2,4,5- trifluorophenyl)butanoic acid: A synthon for sitagliptin and its derivatives

Tetrahedron

Volumn 68, Issue 12, 2012, Pages 2607-2610

  Fistikci, Meryem ^a   Gundogdu, Ozlem ^a   Aktas, Derya ^a   Secen, Hasan ^a   Sahin, M Fethi ^b   Altundas, Ramazan ^a   Kara, Yunus ^a  

^a ATATÜRK UNIVERSITY   (Turkey)

^b Department of Pharmaceutical Research and Development   (Turkey)

Author keywords

(R) and (S) 3 Hydroxy 4 (2,4,5 trifluorophenyl)butanoic acid; Aminoxylation; d andl Proline; Sitagliptin

Indexed keywords

2,4,5 TRIFLUORO 1 IODOBENZENE; 3 HYDROXY 4(2,4,5 TRIFLUOROPHENYL) BUTANENITRILE; 3 HYDROXY 4(2,4,5 TRIFLUOROPHENYL) BUTANOIC ACID; 3(2,4,5 TRIFLUOROPHENYL) PROPANAL; 3(2,4,5 TRIFLUOROPHENYL) PROPANE 1,2 DIOL; ALLYL ALCOHOL; BUTYRIC ACID; CYANIDE; ETHYL 3 HYDROXY 4(2,4,5 TRIFLUORO PHENYL) BUTANOATE; HYDROCINNAMALDEHYDE; HYDROXYACID; HYDROXYL GROUP; IODOBENZENE; NITRILE; NITROSOBENZENE; PROLINE; PROPIONALDEHYDE; PROPYLENE GLYCOL; SITAGLIPTIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HYDROGENATION; HYDROLYSIS; PRIORITY JOURNAL;

TRIFLUORO;

EID: 84857631060     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2012.01.095     Document Type: Article

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