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Volumn 47, Issue 38, 2006, Pages 6813-6815

A short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed asymmetric α-aminooxylation

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ETIRACETAM;

EID: 33747170570     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.07.061     Document Type: Article
Times cited : (58)

References (34)
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    • 33747193955 scopus 로고    scopus 로고
    • Surtees, J.; Marmon, V; Differding, E.; Zimmermann, V. PCT Int. Appl. WO 2001/64367.
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    • Houk K.N., and List B. (Eds)
    • In: Houk K.N., and List B. (Eds). Acc. Chem. Res. 37 (2004) 487
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    • (2004) Adv. Synth. Catal. , pp. 346
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    • For a review of proline-catalyzed asymmetric reactions, see:
    • For a review of proline-catalyzed asymmetric reactions, see:. List B. Tetrahedron 58 (2002) 5573
    • (2002) Tetrahedron , vol.58 , pp. 5573
    • List, B.1
  • 31
    • 33747178249 scopus 로고    scopus 로고
    • note
    • 2 requires C, 72.84; H, 8.56; N, 5.66. Found: C, 72.88; H, 8.55; N, 5.63.
  • 33
    • 33747194261 scopus 로고    scopus 로고
    • note
    • 2 requires C, 56.45; H, 8.29; N, 16.46. Found: C, 56.49; H, 8.34; N, 16.44.
  • 34
    • 4344692607 scopus 로고    scopus 로고
    • HPLC conditions: Chiral OD-H column; hexane: i-PrOH (90:10 v/v); flow rate 1.0 mL/min; UV - 210 nm; column temperature 25 °C; retention time: 10.3 min (R-isomer) and 16.3 min (S-isomer). Compared with reported conditions:
    • HPLC conditions: Chiral OD-H column; hexane: i-PrOH (90:10 v/v); flow rate 1.0 mL/min; UV - 210 nm; column temperature 25 °C; retention time: 10.3 min (R-isomer) and 16.3 min (S-isomer). Compared with reported conditions:. Rao B.M., Ravi R., Reddy B.S., Sivakumar S., Gopi Chand I., Praveen Kumar K., Acharyulu P.V.R., Om Reddy G., and Srinivasu M.K. J. Pharm. Biomed. Anal. 35 (2004) 1017
    • (2004) J. Pharm. Biomed. Anal. , vol.35 , pp. 1017
    • Rao, B.M.1    Ravi, R.2    Reddy, B.S.3    Sivakumar, S.4    Gopi Chand, I.5    Praveen Kumar, K.6    Acharyulu, P.V.R.7    Om Reddy, G.8    Srinivasu, M.K.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.