Warming up to hypothermia for treatment of severe sepsis

Critical Care Medicine

Volumn 40, Issue 3, 2012, Pages 1020-1022

  Crouser, Elliott D ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

ATP; CLP; hypothermia; mitochondrial respiration; organ damage; sepsis

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; BICARBONATE; CALCIUM; LACTIC ACID; OXYGEN;

BACTERIAL GROWTH; BACTERIUM CULTURE; BLOOD GAS; BODY TEMPERATURE; CELL FUNCTION; CELL VIABILITY; DISEASE SEVERITY; EDITORIAL; ELECTRON TRANSPORT; HUMAN; INDUCED HYPOTHERMIA; LUNG INJURY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MORTALITY; MULTIPLE ORGAN FAILURE; NONHUMAN; OXIDATION REDUCTION STATE; OXYGEN CONSUMPTION; OXYGEN TENSION; PRIORITY JOURNAL; SEPSIS; STREPTOCOCCUS PNEUMONIA;

ANIMALS; DIAPHRAGM; FEMALE; MUSCLE WEAKNESS; NF-KAPPA B; VENTILATORS, MECHANICAL;

EID: 84857618493     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31823b894f     Document Type: Editorial

References (19)

1. Gilbert M, Busund R, Skagseth A, et al: Resuscitation from accidental hypothermia of 13.7 degrees C with circulatory arrest. Lancet 2000;355:375-376
2. American Heart Association: American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Part 7.5: Postresuscitation support. Circulation 2005;112:IV-84-IV-88
3. Lampe JW, Becker LB: State of the art in therapeutic hypothermia. Annu Rev Med 2011;62:79-93
4. Tiruvoipati R, Ong K, Gangopadhyay H, et al: Hypothermia predicts mortality in critically ill elderly patients with sepsis. BMC Geriatr 2010;10:70
5. L'Her E, Amerand A, Vettier A, et al: Effects of mild induced hypothermia during experimental sepsis. Crit Care Med 2006;34:2621-2623
6. Beurskens CJP, Aslami H, Kuipers MT, et al: Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover. Crit Care Med 2011;40:927-934
7. Balaban RS, Koretsky AP: Interpretation of 31P NMR saturation transfer experiments: What you can't see might confuse you. Focus on "standard magnetic resonance-based measurements of the Pi3ATP rate do not index the rate of oxidative phosphorylation in cardiac and skeletal muscles." Am J Physiol Cell Physiol 2011;301:C12-C15
8. Brealey D, Brand M, Hargreaves I, et al: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002;360:219-223
9. Erecinska M, Thoresen M, Silver IA: Effects of hypothermia on energy metabolism in mammalian central nervous system. J Cereb Blood Flow Metab 2003;23:513-530
10. Crouser ED, Julian MW, Huff JE, et al: Carbamoyl phosphate synthase-1: A marker of mitochondrial damage and depletion in the liver during sepsis. Crit Care Med 2006;34:2439-2446
11. Bobyleva V, Pazienza L, Muscatello U, et al: Short-term hypothermia activates hepatic mitochondrial sn-glycerol-3-phosphate dehydrogenase and thermogenic systems. Arch Biochem Biophys 2000;380:367-372
12. Liu MS, Zhang JN: Glycolytic and tricarboxylic acid cycle intermediates in dog livers during endotoxic shock. Biochem Med 1985;34:335-343
13. Brown GC: Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J 1992;284:1-13
14. Bravo C, Vargas-Suárez M, Rodríguez-Enríquez S, et al: Moreno-Sánchez R: Metabolic changes induced by cold stress in rat liver mitochondria. J Bioenerg Biomembr 2001;33:289-301
15. Crouser ED, Julian MW, Huff JE, et al: Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia. Crit Care Med 2004;32:478-488
16. Brookes PS: Mitochondrial H (+) leak and ROS generation: An odd couple. Free Radic Biol Med 2005;38:12-23
17. Akriotis V, Biggar WD: The effects of hypothermia on neutrophil function in vivo. J Leukoc Biol 1985;37:51-61
18. Eiseman B, Wotkyns RS, Hirose H: Hypothermia and infection: three mechanisms of host protection in Type II pneumococcal peritonitis. Ann Surg 1964;160:994-1006
19. Membre JM, Leporq B, Vialette M, et al: Temperature effect on bacterial growth rate: Quantitative microbiology approach including cardinal values and variability estimates to perform growth simulations on/in food. Int J Food Microbiol 2005;100:179-186