The strategy for the diagnosis of invasive pulmonary aspergillosis should depend on both the underlying condition and the leukocyte count of patients with hematologic malignancies

Blood

Volumn 119, Issue 8, 2012, Pages 1831-1837

  Bergeron, Anne ^a   Porcher, Raphaël ^b   Sulahian, Annie ^a   De Bazelaire, Cédric ^a   Chagnon, Karine ^a   Raffoux, Emmanuel ^a   Vekhoff, Anne ^a   Cornet, Muriel ^a   Isnard, Françoise ^c   Brethon, Benoit ^a   Lacroix, Claire ^a   Poirot, Jean Louis ^c   Bouges, Claire ^d   Derouin, Francis ^a   Tazi, Abdellatif ^a   Ribaud, Patricia ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITÉ PARIS 13   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; FEMALE; HEMATOLOGIC MALIGNANCY; HUMAN; LEUKEMIA; LEUKOCYTE COUNT; LUNG ASPERGILLOSIS; MAJOR CLINICAL STUDY; MALE; MICROBIOLOGICAL EXAMINATION; MIXED INFECTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STEM CELL TRANSPLANTATION;

EID: 84857617172     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-04-351601     Document Type: Article

References (36)

1. De Pauw B, Walsh TJ, Donnelly JP, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis. 2008;46(12):1813-1821.
2. Neofytos D, Horn D, Anaissie E, et al. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry. Clin Infect Dis. 2009;48(3):265-273.
3. Pagano L, Caira M, Candoni A, et al. The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica. 2006;91(8):1068-1075. (Pubitemid 44208634)
4. Maschmeyer G, Haas A, Cornely OA. Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients. Drugs. 2007;67(11):1567-1601. (Pubitemid 47267298)
5. Caillot D, Couaillier JF, Bernard A, et al. Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia. J Clin Oncol. 2001;19(1):253-259. (Pubitemid 32063503)
6. Herbrecht R, Denning DW, Patterson TF, et al. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med. 2002;347(6):408-415. (Pubitemid 34851833)
7. Greene R. The radiological spectrum of pulmonary aspergillosis. Med Mycol. 2005;43(suppl 1): S147-S154. (Pubitemid 41038563)
8. Nucci M, Nouer SA, Grazziutti M, Kumar NS, Barlogie B, Anaissie E. Probable invasive aspergillosis without prespecified radiologic findings: proposal for inclusion of a new category of aspergillosis and implications for studying novel therapies. Clin Infect Dis. 2010; 51(11):1273-1280.
9. Kojima R, Tateishi U, Kami M, et al. Chest computed tomography of late invasive aspergillosis after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2005; 11(7):506-511. (Pubitemid 40862447)
10. Franquet T, Muller NL, Oikonomou A, Flint JD. Aspergillus infection of the airways: computed tomography and pathologic findings. J Comput Assist Tomogr. 2004;28(1):10-16. (Pubitemid 38057849)
11. Franquet T, Muller NL, Gimenez A, Guembe P, de La Torre J, Bague S. Spectrum of pulmonary aspergillosis: histologic, clinical, and radiologic findings. Radiographics. 2001;21(4):825-837. (Pubitemid 33707878)
12. Orr DP, Myerowitz RL, Dubois PJ. Pathoradiologic correlation of invasive pulmonary aspergillosis in the compromised host. Cancer. 1978;41(5):2028-2039. (Pubitemid 8348559)
13. Logan PM, Primack SL, Miller RR, Muller NL. Invasive aspergillosis of the airways: radiographic, CT, and pathologic findings. Radiology. 1994; 193(2):383-388. (Pubitemid 24338318)
14. Auberger J, Lass-Florl C, Clausen J, et al. First case of breakthrough pulmonary Aspergillus niveus infection in a patient after allogeneic hematopoietic stem cell transplantation. Diagn Microbiol Infect Dis. 2008;62(3):336-339.
15. Madureira A, Bergeron A, Lacroix C, et al. Breakthrough invasive aspergillosis in allogeneic haematopoietic stem cell transplant recipients treated with caspofungin. Int J Antimicrob Agents. 2007;30(6):551-554. (Pubitemid 350051779)
16. Tong SY, PelegAY, Yoong J, Handke R, Szer J, Slavin M. Breakthrough Scedosporium prolificans infection while receiving voriconazole prophylaxis in an allogeneic stem cell transplant recipient. Transpl Infect Dis. 2007;9(3):241-243. (Pubitemid 47231206)
17. Imhof A, Balajee SA, Fredricks DN, Englund JA, Marr KA. Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole. Clin Infect Dis. 2004;39(5):743-746. (Pubitemid 39180450)
18. Walsh TJ, Anaissie EJ, Denning DW, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46(3):327-360. (Pubitemid 351265310)
19. Maertens J, Van Eldere J, Verhaegen J, Verbeken E, Verschakelen J, Boogaerts M. Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients. J Infect Dis. 2002; 186(9):1297-1306. (Pubitemid 35193008)
20. Maertens J, Maertens V, Theunissen K, et al. Bronchoalveolar lavage fluid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases. Clin Infect Dis. 2009;49(11):1688-1693.
21. Levy H, Horak DA, Tegtmeier BR, Yokota SB, Forman SJ. The value of bronchoalveolar lavage and bronchial washings in the diagnosis of invasive pulmonary aspergillosis. Respir Med. 1992; 86(3):243-248.
22. Bergeron A, Belle A, Sulahian A, et al. Contribution of galactomannan antigen detection in BAL to the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies. Chest. 2010;137(2):410-415.
23. Rabbat A, Chaoui D, Lefebvre A, et al. Is BAL useful in patients with acute myeloid leukemia admitted in ICU for severe respiratory complications? Leukemia. 2008;22(7):1361-1367. (Pubitemid 352011840)
24. Berenguer J, Allende MC, Lee JW, et al. Pathogenesis of pulmonary aspergillosis: granulocytopenia versus cyclosporine and methylprednisolone- induced immunosuppression. Am J Respir Crit Care Med. 1995;152(3): 1079-1086.
25. Balloy V, Huerre M, Latge JP, Chignard M. Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis. Infect Immun. 2005;73(1):494-503. (Pubitemid 40041144)
26. Milito MA, Kontoyiannis DP, Lewis RE, et al. Influence of host immunosuppression on CT findings in invasive pulmonary aspergillosis. Med Mycol. 2010;48(6):817-823.
27. Nivoix Y, Velten M, Letscher-Bru V, et al. Factors associated with overall and attributable mortality in invasive aspergillosis. Clin Infect Dis. 2008; 47(9):1176-1184.
28. Ascioglu S, Rex JH, de Pauw B, et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis. 2002;34(1): 7-14. (Pubitemid 33152659)
29. Wingard JR, Carter SL, Walsh TJ, et al. Randomized, double-blind trial of fluconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantation. Blood. 2010;116(24):5111- 5118.
30. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B. 1995;57(1): 289-300.
31. Team RDC. R: A Language and Environment for Statistical Computing. Vienna, Austria; Team RDC; 2008.
32. Caillot D, Latrabe V, Thiebaut A, et al. Computer tomography in pulmonary invasive aspergillosis in hematological patients with neutropenia: an useful tool for diagnosis and assessment of outcome in clinical trials. Eur J Radiol. 2010; 74(3):e172-e175.
33. Shaukat A, Bakri F, Young P, et al. Invasive filamentous fungal infections in allogeneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics. Mycopathologia. 2005; 159(2):181-188. (Pubitemid 40633920)
34. Chamilos G, Luna M, Lewis RE, et al. Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003). Haematologica. 2006;91(7):986-989. (Pubitemid 44023159)
35. Hartman TE, Primack SL, Lee KS, Swensen SJ, Muller NL. CT of bronchial and bronchiolar diseases. Radiographics. 1994;14(5):991-1003.
36. Lass-Florl C, Resch G, Nachbaur D, et al. The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients. Clin Infect Dis. 2007;45(7):e101-e104. (Pubitemid 47580399)