The hinge region of the scaffolding protein of cell contacts, zonula occludens protein 1, regulates interacting with various signaling proteins

Journal of Cellular Biochemistry

Volumn 113, Issue 3, 2012, Pages 934-945

  Bal, Manjot Singh ^a   Castro, Victor ^a   Piontek, Jörg ^a   Rueckert, Christine ^a   Walter, Juliane K ^a   Shymanets, Aliaksei ^b   Kurig, Barbara ^b   Haase, Hannelore ^c   Nürnberg, Bernd ^b   Blasig, Ingolf E ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Cell cell contacts; G proteins; Peptide binding assays; Protein protein interaction; Regulatory proteins; Surface plasmon resonance spectroscopy

Indexed keywords

ADRENALIN; CALCIUM CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA 12; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA I2; PROTEIN ZO1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CELL CONTACT; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SURFACE PLASMON RESONANCE;

CACO-2 CELLS; CELL MEMBRANE; EPITHELIAL CELLS; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; PHOSPHOPROTEINS; RGS PROTEINS;

EID: 84857611636     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23422     Document Type: Article

References (41)

1. Adachi M, Inoko A, Hata M, Furuse K, Umeda K, Itoh M, Tsukita S. 2006. Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein. Mol Cell Biol 26:9003-9015. (Pubitemid 44851957)
2. Andreeva AY, Piontek J, Blasig IE, Utepbergenov DI. 2006. Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. Int J Biochem Cell Biol 38:222-233. (Pubitemid 41619451)
3. Balda MS, Anderson JM, Matter K. 1996. The SH3 domain of the tight junction protein ZO-1 binds to a serine protein kinase that phosphorylates a region C-terminal to this domain. FEBS Lett 399:326-332. (Pubitemid 26426876)
4. Balda MS, Matter K. 2000. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J 19:2024-2033. (Pubitemid 30237578)
5. Bazzoni G, Martinez-Estrada O, Orsenigo F, Cordenosi M, Citi S, Dejana E. 2000. Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem 275:20520-20526. (Pubitemid 30457633)
6. Chen J, Pan L, Wei Z, Zhao Y, Zhang M. 2008. The membrane association domain of RGS16 contains unique amphipathic features that are conserved in RGS4 and RGS5. EMBO J 27:2113-2123.
7. Cocucci E, Racchetti G, Podini P, Rupnik M, Meldolesi J. 2004. Enlargeosome an exocytic vesicle resistant to nonionic detergents, undergoes endocytosis via a nonacidic route. Mol Biol Cell 15:5356-5368. (Pubitemid 39564730)
8. Costes SV, Daelemans D, Cho EH, Dobbin Z, Pavlakis G, Lockett S. 2004. Automatic and quantitative measurement of protein-protein colocalization in live cells Biophys J 86:3993-4003. (Pubitemid 38780275)
9. Denker BM, Saha C, Khawaja S, Nigam SK. 1996. Involvement of a heterotrimeric G protein a subunit in tight junction biogenesis. J Biol Chem 271:25750-25753. (Pubitemid 26347401)
10. Fanning AS, Jameson BJ, Jesaitis LA, Anderson LM. 1998. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem 273:29745-29753. (Pubitemid 28509986)
11. Fanning AS, Ma TY, Anderson JM. 2002. Isolation and functional characterization of the actin-binding region in the tight junction protein ZO-1. FASEB J 16:1835-1837.
12. Fanning AS, Little BP, Rahner C, Utepbergenov D, Walther Z, Anderson JM. 2007. The unique-5 and -6 motifs of ZO-1 regulate tight junction strand localization and scaffolding properties. Mol Biol Cell 18:721-731. (Pubitemid 46399480)
13. Frank R, Overwin H. 1996. SPOT synthesis: Epitope analysis with arrays of synthetic peptides prepared on cellulose membranes. Methods Mol Biol 66:149-169.
14. Gaibelet G, Meilhoc E, Riond J, Saves I, Exner T, Liaubet L, Nurnberg B, Masson JM, Emorine LJ. 1999. Nonselective coupling of the human muopioid receptor to multiple inhibitory G-protein isoforms. Eur J Biochem 261:517-523. (Pubitemid 29187499)
15. Gentil BJ, Benaud C, Delphin C, Remy C, Berezowski V, Cecchelli R, Feraud O, Vittet D, Baudier J. 2005. Specific AHNAK expression in brain endothelial cells with barrier properties. J Cell Physiol 203:362-371. (Pubitemid 40471770)
16. Gohla A, Offermanns S, Wilkie TM, Schultz G. 1999. Differential involvement of G alpha(12) and G alpha(13) in receptor-mediated stress fiber formation. J Biol Chem 274:17901-17907.
17. Haase H, Podzuweit T, Lutsch G, Hohaus A, Kostka S, Lindschau C, Kott M, Kraft R, Morano I, 1999. Signaling from beta-adrenoceptor to L-type calcium channel: Identification of a novel cardiac protein kinase A target possessing similarities to AHNAK. FASEB J 13:2161-2172.
18. Haase H, Alvarez J, Petzhold D, Doller A, Behlke J, Erdmann J, Hetzer R, Regitz-Zagrosek V, Vassort G, Morano I. 2005. Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation. FASEB J 19:1969-1977. (Pubitemid 41759742)
19. Haase H. 2007. Ahnak, a new player in beta-adrenergic regulation of the cardiac L-type Ca2+ channel Cardiovasc Res. 73:19-25. (Pubitemid 44937179)
20. Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H. 2002. The carboxyl-terminal region of ahnak provides a link between cardiac Ltype Ca2+ channels and the actin-based cytoskeleton. FASEB J 16:1205-1216. (Pubitemid 34815408)
21. Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S. 1999. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2 and ZO-3, with the COOH termini of claudins. J Cell Biol 147:1351-1363. (Pubitemid 30012818)
22. Lippoldt A, Kirsch T, Rascher G, Kalbacher H, Wolburg H, Haller H. 2001. RGS5 is new a regulatory protein in tight junctions of endothelial cells is decreased in cerebral endothelial cells of SHRSP. Hypertension 38:964.
23. Lye MF, Fanning AS, Su Y, Anderson JM, Lavie A. 2010. Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. J Biol Chem 285:13907-13917.
24. Masuko N, Makino K, Kuwahara H, Fukunaga K, Sudo T, Araki N, Yamamoto H, Yamada Y, Miyamoto E, Saya H. 1999. Interaction of NE-dlg/SAP102, aneuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90-A possible regulatory role in molecular clustering at synaptic sites. J Biol Chem 274:5782-5790. (Pubitemid 29109234)
25. McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE. 2001. Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Mol Cell 8:1291-1301. (Pubitemid 34085000)
26. Meyer TN, Schwesinger C, Denker BM. 2002. Zonula occludens-1 is a scaffolding protein for signaling molecules-G alpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells. J Biol Chem 277:24855-24858. (Pubitemid 34951784)
27. Mueller SL, Portwich M, Schmidt A, Utepbergenov DI, Huber O, Blasig IE, Krause G. 2005. The tight junction protein occludin and the adherens junction protein a-catenin share a common interaction mechanism with ZO-1. J Biol Chem 280:3747-3756. (Pubitemid 40223843)
28. Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S. 2003. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161:653-660. (Pubitemid 36578587)
29. Pozgajova M, Sachs UJH, Hein L, Nieswandt B. 2006. Reduced thrombus stability in mice lacking the alpha(2A)-adrenergic receptor. Blood 108:510-514. (Pubitemid 44061349)
30. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. 2011. Synergistic Ca2+ responses by G{alpha}i-and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{-gamma} and G{alpha}q. J Biol Chem 286:942-951.
31. Saha C, Nigam SK, Denker BM. 1998. Involvement of G alpha(i2) in the maintenance and biogenesis of epithelial cell tight junctions. J Biol Chem 273:21629-21633. (Pubitemid 28405334)
32. Schmidt A, Utepbergenov DI, Krause G, Blasig IE. 2001. Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin. Biochem Biophys Res Commun 288:1194-1199. (Pubitemid 33131727)
33. Schmidt A, Utepbergenov DI, Mueller SL, Beyermann M, Schneider-Mergener J, Krause G, Blasig IE. 2004. Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1-Potential mechanism of tight junction regulation. Cell Mol Life Sci 61:1354-1365. (Pubitemid 38822424)
34. Soma T, Chiba H, Kato-Mori Y, Wada T, Yamashita T, Kojima T, Sawada N. 2004. Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP. Exp Cell Res 300:202-212. (Pubitemid 39286229)
35. Sussman J, Stokoe D, Ossina N, Shtivelman E. 2001. Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. J Cell Biol 154:1019-1030. (Pubitemid 34286181)
36. Taliana L, Benezra M, Greenberg RS, Masur SK, Bernstein AM. 2005. ZO-1: Lamellipodial localization in a corneal fibroblast wound model. Invest Ophthalmol Vis Sci 4:96-103. (Pubitemid 40041184)
37. Umeda K, Matsui T, Nakayama M, Furuse K, Sasaki H, Furuse M, Tsukita S. 2004. Establishment and characterization of cultured epithelial cells lacking expression of ZO-1. J Biol Chem 27:44785-44794. (Pubitemid 39430889)
38. Utepbergenov DI, Fanning AS, Anderson JM. 2006. Dimerization of the scaffolding protein ZO-1 through the second PDZ domain. J Biol Chem 281:24671-24677. (Pubitemid 44274240)
39. Walter JK, Castro V, Voss M, Gast K, Rueckert C, Piontek J, Blasig IE. 2009. Redox-sensitivity of the dimerization of occludin. Cell Mol Life Sci 66:3655-3662.
40. Willard FS, Zheng Z, Guo J, Digby GJ, Kimple AJ, Conley JM, Johnston CA, Bosch D, Willard MD, Watts VJ, Lambert NA, Ikeda SR, Du Q, Siderovski DP. 2008. A point mutation to Gai selectively blocks GoLoco motif binding: Direct evidence for Ga GoLoco complexes in mitotic spindle dynamics. J Biol Chem 28:36698-36710.
41. Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S. 2001. Characterization of RGS5 in regulation of G protein-coupled receptor signaling. Life Sci 68:1457-1469. (Pubitemid 32168073)