Chemical reduction of carboxyl groups in heparin abolishes its vasodilatory activity

Journal of Cellular Biochemistry

Volumn 113, Issue 4, 2012, Pages 1359-1367

  Paredes Gamero, Edgar J ^a   Medeiros, Valquíria P ^a   Lima, Marcelo A ^a   Accardo, Camila M ^a   Farias, Eduardo H C ^a   Sassaki, Guilherme I ^b   Campana, Patricia T ^c   Miranda, Antonio ^a   Ferreira, Alice T ^a   Tersariol, Ivarne L S ^a   Nader, Helena B ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

AORTA; CARBOXYLGROUP; HEPARIN; SULFATION; VASCULAR RELAXATION

Indexed keywords

CARBOXYL GROUP; DEXTRAN; DEXTRAN SULFATE; GLUCOSAMINE; GLUCURONIC ACID; HEPARIN; IDURONIC ACID; POLYSACCHARIDE SULFATE; URONIC ACID;

ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODEL; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; EXTRACELLULAR MATRIX; HEMOSTASIS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; INTESTINE MUCOSA; MALE; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SUBSTITUTION REACTION; SULFATION; THROMBOSIS; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA; CATTLE; CIRCULAR DICHROISM; HEPARIN; INTESTINAL MUCOSA; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR WEIGHT; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET; VASODILATOR AGENTS;

BOVINAE; RATTUS;

EID: 84857609340     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24008     Document Type: Article

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