Short- and long-term immunological and virological outcome in HIV-infected infants according to the age at antiretroviral treatment initiation

Clinical Infectious Diseases

Volumn 54, Issue 6, 2012, Pages 878-881

  Goetghebuer, Tessa ^a   Chenadec, Jerome Le ^b   Haelterman, Edwige ^a   Galli, Luisa ^c   Dollfus, Catherine ^d   Thorne, Claire ^e   Judd, Ali ^f   Keiser, Olivia ^g,h   Ramos, Jose Tomas ⁱ   Levy, Jack ^a   Warszawski, Josiane ^b,j  

^a SAINT PIERRE UNIVERSITY HOSPITAL   (Belgium)

^b INSERM   (France)

^c UNIVERSITY OF FLORENCE   (Italy)

^d ARMAND TROUSSEAU HOSPITAL   (France)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f MRC CLINICAL TRIALS UNIT   (United Kingdom)

^g Data Center of the Swiss HIV Cohort Study   (Switzerland)

^h UNIVERSITY OF BERN   (Switzerland)

ⁱ HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^j UNIVERSITÉ PARIS SACLAY   (France)

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Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT;

AGE DISTRIBUTION; ANTIVIRAL THERAPY; ARTICLE; COHORT ANALYSIS; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; INFANT; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; NEWBORN; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VIROLOGY;

AGE FACTORS; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; HIV INFECTIONS; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; MONTE CARLO METHOD; PROPORTIONAL HAZARDS MODELS; STATISTICS, NONPARAMETRIC; TIME FACTORS; VIRAL LOAD;

EID: 84857600302     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cir950     Document Type: Article

References (12)

1. Gray L, Newell ML, Thorne C, Peckham C, Levy J. Fluctuations in symptoms in human immunodeficiency virus-infected children: the first 10 years of life. Pediatrics 2001; 108:116-22. (Pubitemid 32592014)
2. Violari A, Cotton MF, Gibb DM, et al. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 2008; 359: 2233-44.
3. Goetghebuer T, Haelterman E, Le Chenadec J, et al. Effect of early antiretroviral therapy on the risk of AIDS/death in HIV-infected infants. AIDS 2009; 23:597-604.
4. Bunders M, Cortina-Borja M, Newell ML. Age-related standards for total lymphocyte, CD41 and CD81 T cell counts in children born in Europe. Pediatr Infect Dis J 2005; 24:595-600. (Pubitemid 40993612)
5. Luzuriaga K, Bryson Y, Krogstad P, et al. Combination treatment with zidovudine, didanosine, and nevirapine in infants with human immunodeficiency virus type 1 infection. N Engl J Med 1997; 336: 1343-9. (Pubitemid 27208617)
6. Hainaut M, Peltier CA, Gerard M, Marissens D, Zissis G, Levy J. Effectiveness of antiretroviral therapy initiated before the age of 2 months in infants vertically infected with human immunodeficiency virus type 1. Eur J Pediatr 2000; 159:778-82.
7. Friedman J. A variable span scatterplot smoother. Laboratory for Computational Statistics. Stanford University technical report. JASA 1984; 1-16.
8. Bunders M, Thorne C, Newell ML. Maternal and infant factors and lymphocyte, CD4 and CD8 cell counts in uninfected children of HIV-1-infected mothers. AIDS 2005; 19:1071-9. (Pubitemid 40961148)
9. Doerholt K, Duong T, Tookey P, et al. Outcomes for human immunodeficiency virus-1-infected infants in the United Kingdom and Republic of Ireland in the era of effective antiretroviral therapy. Pediatr Infect Dis J 2006; 25:420-6.
10. Luzuriaga K, McManus M, Mofenson L, Britto P, GrahamB, Sullivan JL. A trial of three antiretroviral regimens in HIV-1-infected children. N Engl J Med 2004; 350:2471-80. (Pubitemid 38736544)
11. Chiappini E, Galli L, Tovo PA, et al. Virologic, immunologic, and clinical benefits from early combined antiretroviral therapy in infants with perinatal HIV-1 infection. AIDS 2006; 20:207-15.
12. Van der Linden D, Hainaut M, Goetghebuer T, et al. Effectiveness of early initiation of protease inhibitor-sparing antiretroviral regimen in human immunodeficiency virus-1 vertically infected infants. Pediatr Infect Dis J 2007; 26:359-61. (Pubitemid 46596667)