Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation

Pediatric Transplantation

Volumn 16, Issue 2, 2012, Pages

  Jodele, Sonata ^a   Bleesing, Jack J ^a   Mehta, Parinda A ^a   Filipovich, Alexandra H ^a   Laskin, Benjamin L ^a   Goebel, Jens ^a   Pinkard, Susan L ^b   Davies, Stella M ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

hematopoietic stem cell transplantation; pediatrics; TA TMA; transplant associated thrombotic microangiopathy

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; METHYLPREDNISOLONE; RITUXIMAB; THYMOCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CASE REPORT; CHILD; CORD BLOOD STEM CELL TRANSPLANTATION; DRUG DOSE INCREASE; DRUG WITHDRAWAL; FEMALE; GRAFT VERSUS HOST REACTION; HEMOLYSIS; HUMAN; HUMAN TISSUE; HYPERACUTE GRAFT REJECTION; INTENSIVE CARE; KIDNEY FAILURE; LABORATORY TEST; MULTIPLE ORGAN FAILURE; PLASMAPHERESIS; POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME; PRESCHOOL CHILD; RENAL REPLACEMENT THERAPY; RESPIRATORY FAILURE; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT OUTCOME;

CHILD, PRESCHOOL; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA, MYELOID, ACUTE; POSTOPERATIVE COMPLICATIONS; THROMBOTIC MICROANGIOPATHIES;

EID: 84857595082     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2010.01408.x     Document Type: Article

References (16)

1. George JN,. Hematopoietic stem cell transplantation-associated thrombotic microangiopathy: Defining a disorder. Bone Marrow Transplant 2008: 41: 917-918. (Pubitemid 351850493)
2. Batts ED, Lazarus HM,. Diagnosis and treatment of transplantation- associated thrombotic microangiopathy: Real progress or are we still waiting? Bone Marrow Transplant 2007: 40: 709-719. (Pubitemid 47521528)
3. Ho VT, Cutler C, Carter S, et al., Blood and marrow transplant clinical trials network toxicity committee consensus summary: Thrombotic microangiopathy after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005: 11: 571-575. (Pubitemid 41001631)
4. Ruutu T, Barosi G, Benjamin RJ, et al., Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: Results of a consensus process by an International Working Group. Haematologica 2007: 92: 95-100. (Pubitemid 46232661)
5. Kennedy GA, Bleakley S, Butler J, Mudie K, Kearey N, Durrant S,. Posttransplant thrombotic microangiopathy: Sensitivity of proposed new diagnostic criteria. Transfusion 2009: 49: 1884-1889.
6. George JN, Li X, McMinn JR, Terrell DR, Vesely SK, Selby GB,. Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome following allogeneic HPC transplantation: A diagnostic dilemma. Transfusion 2004: 44: 294-304. (Pubitemid 38236394)
7. Nakamae H, Yamane T, Hasegawa T, et al., Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation. Am J Hematol 2006: 81: 525-531.
8. Daly AS, Xenocostas A, Lipton JH,. Transplantation-associated thrombotic microangiopathy: Twenty-two years later. Bone Marrow Transplant 2002: 30: 709-715. (Pubitemid 36004298)
9. Choi CM, Schmaier AH, Snell MR, Lazarus HM,. Thrombotic microangiopathy in haematopoietic stem cell transplantation: Diagnosis and treatment. Drugs 2009: 69: 183-198.
10. Au WY, Ma ES, Lee TL, et al., Successful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximab. Br J Haematol 2007: 137: 475-478. (Pubitemid 46698288)
11. Uderzo C, Bonanomi S, Busca A, et al., Risk factors and severe outcome in thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. Transplantation 2006: 82: 638-644. (Pubitemid 44395233)
12. Noris M, Remuzzi G,. Atypical hemolytic-uremic syndrome. N Engl J Med 2009: 361: 1676-1687.
13. Waters AM, Pappworth I, Marchbank K, et al., Successful renal transplantation in factor H autoantibody associated HUS with CFHR1 and 3 deficiency and CFH variant G2850T. Am J Transplant 2010: 10: 168-172.
14. Kennedy GA, Kearey N, Bleakley S, Butler J, Mudie K, Durrant S,. Transplantation-associated thrombotic microangiopathy: Effect of concomitant GVHD on efficacy of therapeutic plasma exchange. Bone Marrow Transplant 2010: 45: 699-704.
15. Waters AM, Licht C,. aHUS caused by complement dysregulation: New therapies on the horizon. Pediatr Nephrol 2010: Jun 18. [Epub ahead of print].
16. Laskin BL, Goebel J, Davies SM, et al., Early clinical indicators of transplant-associated thrombotic microangiopathy in pediatric neuroblastoma patients undergoing auto-SCT. Bone Marrow Transplant 2010: Aug 9. [Epub ahead of print].