-
1
-
-
0142087554
-
Antibodies as therapeutic agents: Vive la renaissance!
-
DOI 10.1517/14712598.3.7.1133
-
Stockwin, L. H.; Holmes, S. Antibodies as therapeutic agents: vive la renaissance! Expert Opin. Biol. Ther. 2003, 3, 1133-1152 (Pubitemid 37295768)
-
(2003)
Expert Opinion on Biological Therapy
, vol.3
, Issue.7
, pp. 1133-1152
-
-
Stockwin, L.H.1
Holmes, S.2
-
2
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
Arkin, M. R.; Wells, J. A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream Nat. Rev. Drug Discovery 2004, 3, 301-317 (Pubitemid 38499758)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.4
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
3
-
-
0026688157
-
Evaluation of the stability of peptides and pseudopeptides as a tool in peptide drug design
-
Fauchère, J. L.; Thurieau, C. Evaluation of the stability of peptides and pseudopeptides as a tool in peptide drug design Adv. Drug. Res. 1992, 23, 128-159
-
(1992)
Adv. Drug. Res.
, vol.23
, pp. 128-159
-
-
Fauchère, J.L.1
Thurieau, C.2
-
4
-
-
0036158878
-
Peptides as drugs: Is there a market ?
-
Loffet, A. Peptides as drugs: is there a market ? J. Peptide Sci. 2002, 8, 1-7
-
(2002)
J. Peptide Sci.
, vol.8
, pp. 1-7
-
-
Loffet, A.1
-
5
-
-
0037061646
-
Inhibition of protein-protein association by small molecules: Approaches and progress
-
DOI 10.1021/jm010468s
-
Toogood, P. L. Inhibition of protein-protein association by small molecules: approaches and progress J. Med. Chem. 2002, 45, 1543-1558 (Pubitemid 34293520)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.8
, pp. 1543-1558
-
-
Toogood, P.L.1
-
6
-
-
0028916599
-
A Hot Spot of Binding Energy in a Hormone-Receptor Interface
-
Clackson, T.; Wells, J. A. A Hot Spot of Binding Energy in a Hormone-Receptor Interface Science 1995, 267, 38-386
-
(1995)
Science
, vol.267
, pp. 38-386
-
-
Clackson, T.1
Wells, J.A.2
-
7
-
-
0037170794
-
Biphenyls as potential mimetics of protein alpha-helix
-
DOI 10.1016/S0960-894X(02)00031-8, PII S0960894X02000318
-
Jacoby, E. Biphenyls as Potential Mimetics of Protein a-Helix Bioorg. Med. Chem. Lett. 2002, 12, 891-893 (Pubitemid 34214968)
-
(2002)
Bioorganic and Medicinal Chemistry Letters
, vol.12
, Issue.6
, pp. 891-893
-
-
Jacoby, E.1
-
8
-
-
0025675385
-
Metal ion-enhanced helicity in synthetic peptides containing unnatural, metal-ligating residues
-
Ruan, F. Q.; Chen, Y. Q.; Hopkins, P. B. Metal ion-enhanced helicity in synthetic peptides containing unnatural, metal-ligating residues J. Am. Chem. Soc. 1990, 112, 9403-9404
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 9403-9404
-
-
Ruan, F.Q.1
Chen, Y.Q.2
Hopkins, P.B.3
-
9
-
-
0029972738
-
The Design of Dipeptide Helical Mimetics: The Synthesis, Tachykinin Receptor Affinity and Conformational Analysis of 1,1,6-Trisubstituted Indanes
-
Horwell, D. C.; Howson, W.; Ratcliffe, G. S.; Willems, H. M. G. The Design of Dipeptide Helical Mimetics: The Synthesis, Tachykinin Receptor Affinity and Conformational Analysis of 1,1,6-Trisubstituted Indanes Bioorg. Med. Chem. 1996, 4, 33-42
-
(1996)
Bioorg. Med. Chem.
, vol.4
, pp. 33-42
-
-
Horwell, D.C.1
Howson, W.2
Ratcliffe, G.S.3
Willems, H.M.G.4
-
10
-
-
34247138372
-
Facile synthesis of benzamides to mimic an alpha-helix
-
DOI 10.1016/j.tetlet.2007.03.108, PII S0040403907005631
-
Ahn, J.-M.; Han, S.-Y. Dacile synthesis of benzamides to mimic an α-helix Tetrahedron Lett. 2007, 48, 3543-3547 (Pubitemid 46590196)
-
(2007)
Tetrahedron Letters
, vol.48
, Issue.20
, pp. 3543-3547
-
-
Ahn, J.-M.1
Han, S.-Y.2
-
11
-
-
14844298684
-
Design and synthesis of a trans-fused polycyclic ether skeleton as an alpha-helix mimetic scaffold
-
DOI 10.1016/j.tetlet.2005.02.039
-
Oguri, H.; Oomura, A.; Tanabe, S.; Hirama, M. Design and synthesis of a trans-fused polycyclic ether skeleton as an α-helix mimetic scaffold Tetrahedron Lett. 2005, 46, 2179-2183 (Pubitemid 40340125)
-
(2005)
Tetrahedron Letters
, vol.46
, Issue.13
, pp. 2179-2183
-
-
Oguri, H.1
Oomura, A.2
Tanabe, S.3
Hirama, M.4
-
12
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
DOI 10.1038/nature03579
-
Oltersdorf, T.; Elmore, S. W.; Shoemaker, A. R.; Armstrong, R. C.; Augeri, D. J.; Belli, B. A.; Bruncko, M.; Deckwerth, T. L.; Dinges, J.; Hajduk, P. J.; Joseph, M. K.; Kitada, S.; Korsmeyer, S. J.; Kunzer, A. R.; Letai, A.; Li, C.; Mitten, M. J.; Nettesheim, D. G.; Ng, S.; Nimmer, P. M.; O'Connor, J. M.; Oleksijew, A.; Petros, A. M.; Reed, J. C.; Shen, W.; Tahir, S. K.; Thompson, C. B.; Tomaselli, K. J.; Wang, B.; Wendt, M. D.; Zhang, H.; Fesik, S. W.; Rosenberg, S. H. An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature 2005, 435, 677-681 (Pubitemid 40825512)
-
(2005)
Nature
, vol.435
, Issue.7042
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
Bruncko, M.7
Deckwerth, T.L.8
Dinges, J.9
Hajduk, P.J.10
Joseph, M.K.11
Kitada, S.12
Korsmeyer, S.J.13
Kunzer, A.R.14
Letai, A.15
Li, C.16
Mitten, M.J.17
Nettesheim, D.G.18
Ng, S.19
Nimmer, P.M.20
O'Connor, J.M.21
Oleksijew, A.22
Petros, A.M.23
Reed, J.C.24
Shen, W.25
Tahir, S.K.26
Thompson, C.B.27
Tomaselli, K.J.28
Wang, B.29
Wendt, M.D.30
Zhang, H.31
Fesik, S.W.32
Rosenberg, S.H.33
more..
-
13
-
-
22144454687
-
Strategies for targeting protein-protein interactions with synthetic agents
-
DOI 10.1002/anie.200461786
-
Yin, H.; Hamilton, A. D. Strategies for targeting protein-protein interactions with synthetic agents Angew. Chem., Int. Ed. 2005, 44, 4130-4163 (Pubitemid 40982718)
-
(2005)
Angewandte Chemie - International Edition
, vol.44
, Issue.27
, pp. 4130-4163
-
-
Yin, H.1
Hamilton, A.D.2
-
14
-
-
59149107045
-
α-Helix mimetics as inhibitors of protein-protein interactions
-
Saraogi, I.; Hamilton, A. D. α-Helix mimetics as inhibitors of protein-protein interactions Biochem. Soc. Trans. 2008, 36, 1414-1417
-
(2008)
Biochem. Soc. Trans.
, vol.36
, pp. 1414-1417
-
-
Saraogi, I.1
Hamilton, A.D.2
-
15
-
-
0034801374
-
Toward proteomimetics: Terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix [18]
-
DOI 10.1021/ja0025548
-
Orner, B. P.; Ernst, J. T.; Hamilton, A. D. Toward Proteomimetics: Terphenyl Derivatives as Structural and Functional Mimics of Extended Regions of an α-Helix J. Am. Chem. Soc. 2001, 123, 5382-5383 (Pubitemid 32910693)
-
(2001)
Journal of the American Chemical Society
, vol.123
, Issue.22
, pp. 5382-5383
-
-
Orner, B.P.1
Ernst, J.T.2
Hamilton, A.D.3
-
16
-
-
33745181229
-
Development of small molecules designed to modulate protein-protein interactions
-
DOI 10.1007/s10822-006-9040-8
-
Che, Y.; Brooks, B. R.; Marshall, G. R. Development of small molecules designed to modulate protein-protein interactions J. Comput.-Aided Mol. Des 2006, 20, 109-130 (Pubitemid 43899121)
-
(2006)
Journal of Computer-Aided Molecular Design
, vol.20
, Issue.2
, pp. 109-130
-
-
Che, Y.1
Brooks, B.R.2
Marshall, G.R.3
-
17
-
-
84857607825
-
-
Release 2.0; Accelrys Software Inc. San Diego, CA.
-
Discovery Studio Modeling Environment, Release 2.0; Accelrys Software Inc.: San Diego, CA, 2005.
-
(2005)
Discovery Studio Modeling Environment
-
-
-
18
-
-
0004133516
-
-
Revision A.11.1; Gaussian, Inc. Pittsburgh PA.
-
Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Zakrzewski, V. G.; Montgomery, J. A., Jr.; Stratmann, R. E.; Burant, J. C.; Dapprich, S.; Millam, J. M.; Daniels, A. D.; Kudin, K. N.; Strain, M. C.; Farkas, O.; Tomasi, J.; Barone, V.; Cossi, M.; Cammi, R.; Mennucci, B.; Pomelli, C.; Adamo, C.; Clifford, S.; Ochterski, J.; Petersson, G. A.; Ayala, P. Y.; Cui, Q.; Morokuma, K.; Salvador, P.; Dannenberg, J. J.; Malick, D. K.; Rabuck, A. D.; Raghavachari, K.; Foresman, J. B.; Cioslowski, J.; Ortiz, J. V.; Baboul, A. G.; Stefanov, B. B.; Liu, G.; Liashenko, A.; Piskorz, P.; Komaromi, I.; Gomperts, R.; Martin, R. L.; Fox, D. J.; Keith, T.; Al-Laham, M. A.; Peng, C. Y.; Nanayakkara, A.; Challacombe, M.; Gill, P. M. W.; Johnson, B.; Chen, W.; Wong, M. W.; Andres, J. L.; Gonzalez, C.; Head-Gordon, M.; Replogle, E. S.; Pople, J. A. Gaussian 98, Revision A.11.1; Gaussian, Inc.: Pittsburgh PA, 2001.
-
(2001)
Gaussian 98
-
-
Frisch, M.J.1
Trucks, G.W.2
Schlegel, H.B.3
Scuseria, G.E.4
Robb, M.A.5
Cheeseman, J.R.6
Zakrzewski, V.G.7
Montgomery Jr., J.A.8
Stratmann, R.E.9
Burant, J.C.10
Dapprich, S.11
Millam, J.M.12
Daniels, A.D.13
Kudin, K.N.14
Strain, M.C.15
Farkas, O.16
Tomasi, J.17
Barone, V.18
Cossi, M.19
Cammi, R.20
Mennucci, B.21
Pomelli, C.22
Adamo, C.23
Clifford, S.24
Ochterski, J.25
Petersson, G.A.26
Ayala, P.Y.27
Cui, Q.28
Morokuma, K.29
Salvador, P.30
Dannenberg, J.J.31
Malick, D.K.32
Rabuck, A.D.33
Raghavachari, K.34
Foresman, J.B.35
Cioslowski, J.36
Ortiz, J.V.37
Baboul, A.G.38
Stefanov, B.B.39
Liu, G.40
Liashenko, A.41
Piskorz, P.42
Komaromi, I.43
Gomperts, R.44
Martin, R.L.45
Fox, D.J.46
Keith, T.47
Al-Laham, M.A.48
Peng, C.Y.49
Nanayakkara, A.50
Challacombe, M.51
Gill, P.M.W.52
Johnson, B.53
Chen, W.54
Wong, M.W.55
Andres, J.L.56
Gonzalez, C.57
Head-Gordon, M.58
Replogle, E.S.59
Pople, J.A.60
more..
-
19
-
-
0022348446
-
A novel synthesis of 4-aryl- and 4-heteroarylpyridines via diethyl(4-pyridyl)borane
-
Ishikura, M.; Ohta, T.; Terashima, M. A novel synthesis of 4-aryl- and 4-heteroarylpyridines via diethyl(4-pyridyl)borane Chem. Pharm. Bull. 1985, 33, 4755-4763 (Pubitemid 16181311)
-
(1985)
Chemical and Pharmaceutical Bulletin
, vol.33
, Issue.11
, pp. 4755-4763
-
-
Ishikura, M.1
Ohta, T.2
Terashima, M.3
-
21
-
-
0036270264
-
Cross-coupling between 3-pyridylmagnesium chlorides and heteroaromatic halides
-
Bonnet, V.; Mongin, F.; Trecourt, F.; Breton, G.; Marsais, F.; Knochel, P.; Queguiner, G. Cross-coupling between 3-pyridylmagnesium chlorides and heteroatomic halides Synlett 2002, 6, 1008-1010 (Pubitemid 34620760)
-
(2002)
Synlett
, Issue.6
, pp. 1008-1010
-
-
Bonnet, V.1
Mongin, F.2
Trecourt, F.3
Breton, G.4
Marsais, F.5
Knochel, P.6
Queguiner, G.7
-
22
-
-
66349096300
-
Synthesis of dihalo bi- and terpyridines by regioselective Suzuki-Miyaura cross-coupling reactions
-
Burzicki, G.; Voisin-Chiret, A. S.; Sopkova-de Oliveira Santos, J.; Rault, S. Synthesis of dihalo bi- and terpyridines by regioselective Suzuki-Miyaura cross-coupling reactions Tetrahedron 2009, 65, 5413-5417
-
(2009)
Tetrahedron
, vol.65
, pp. 5413-5417
-
-
Burzicki, G.1
Voisin-Chiret, A.S.2
Sopkova-De Oliveira Santos, J.3
Rault, S.4
-
23
-
-
84943920736
-
Phase Annealing in SHELX -90: Direct Methods for Larger Structures
-
Sheldrick, G. M. Phase Annealing in SHELX -90: Direct Methods for Larger Structures Acta Crystallogr. 1990, A46, 467-473
-
(1990)
Acta Crystallogr.
, vol.46
, pp. 467-473
-
-
Sheldrick, G.M.1
-
24
-
-
37549039510
-
A short history of SHELX
-
Sheldrick, G. M. A short history of SHELX Acta Crystallogr. 2008, A64, 112-122
-
(2008)
Acta Crystallogr.
, vol.64
, pp. 112-122
-
-
Sheldrick, G.M.1
-
25
-
-
28844437779
-
Synthesis of a 2,3′;6′,3-terpyridine scaffold as an alpha-helix mimetic
-
DOI 10.1021/ol0521228
-
Davis, J. M.; Truong, A.; Hamilton, A. D. Synthesis of a 2,3′;6′,3″-Terpyridine Scaffold as an α-Helix Mimetic Org. Lett. 2005, 7, 5405-5408 (Pubitemid 41775143)
-
(2005)
Organic Letters
, vol.7
, Issue.24
, pp. 5405-5408
-
-
Davis, J.M.1
Truong, A.2
Hamilton, A.D.3
-
26
-
-
0036532565
-
Synthesis of novel halopyridinylboronic acids and esters. Part 1: 6-Halopyridin-3-yl-boronic acids and esters
-
DOI 10.1016/S0040-4020(02)00152-7, PII S0040402002001527
-
Bouillon, A.; Lancelot, J.-C.; Collot, V.; Bovy, P.-R.; Rault, S. Synthesis of novel halopyridinylboronic acids and esters. Part 1: 6-Halopyridin-3-yl-boronic acids and esters Tetrahedron 2002, 58, 2885-2890 (Pubitemid 34243036)
-
(2002)
Tetrahedron
, vol.58
, Issue.14
, pp. 2885-2890
-
-
Bouillon, A.1
Lancelot, J.-C.2
Collot, V.3
Bovy, P.R.4
Rault, S.5
-
27
-
-
0037156677
-
Synthesis of novel halopyridinylboronic acids and esters. Part 2: 2,4, or 5-Halopyridin-3-yl-boronic acids and esters
-
Bouillon, A.; Lancelot, J.-C.; Collot, V.; Bovy, P.-R.; Rault, S. Synthesis of novel halopyridinylboronic acids and esters. Part 2: 2,4, or 5-Halopyridin-3-yl-boronic acids and esters Tetrahedron 2002, 58, 3323-3328
-
(2002)
Tetrahedron
, vol.58
, pp. 3323-3328
-
-
Bouillon, A.1
Lancelot, J.-C.2
Collot, V.3
Bovy, P.-R.4
Rault, S.5
-
28
-
-
0037182035
-
Synthesis of novel halopyridinylboronic acids and esters. Part 3: 2, or 3-Halopyridin-4-yl-boronic acids and esters
-
DOI 10.1016/S0040-4020(02)00416-7, PII S0040402002004167
-
Bouillon, A.; Lancelot, J.-C.; Collot, V.; Bovy, P.-R.; Rault, S. Synthesis of novel halopyridinylboronic acids and esters. Part 3: 2, or 3-Halopyridin-4-yl-boronic acids and esters Tetrahedron 2002, 58, 4369-4373 (Pubitemid 34522028)
-
(2002)
Tetrahedron
, vol.58
, Issue.22
, pp. 4369-4373
-
-
Bouillon, A.1
Lancelot, J.-C.2
Collot, V.3
Bovy, P.R.4
Rault, S.5
-
29
-
-
0242467635
-
Synthesis of novel halopyridinylboronic acids and esters. Part 4: Halopyridin-2-yl-boronic acids and esters are stable, crystalline partners for classical Suzuki cross-coupling
-
DOI 10.1016/j.tet.2003.10.020
-
Bouillon, A.; Lancelot, J.-C.; Sopkova-de Oliveira Santos, J.; Collot, V.; Bovy, P.-R.; Rault, S. Synthesis of novel halopyridinylboronic acids and esters. Part 4: Halopyridin-2-yl-boronic acids and esters are stable, crystalline partners for classical Suzuki cross-coupling Tetrahedron 2003, 59, 10043-10049 (Pubitemid 37434058)
-
(2003)
Tetrahedron
, vol.59
, Issue.50
, pp. 10043-10049
-
-
Bouillon, A.1
Lancelot, J.-C.2
Santos, J.S.D.O.3
Collot, V.4
Bovy, P.R.5
Rault, S.6
-
30
-
-
33750737691
-
Novel oxybispyridylboronic acids: synthesis and study of their reactivity in Suzuki-type cross-coupling reactions
-
DOI 10.1016/j.tet.2006.09.036, PII S0040402006015006
-
Voisin, A. S.; Bouillon, A.; Berenguer, I.; Lancelot, J.-C.; Lesnard, A.; Rault, S. Novel oxybispyridylboronic acids: synthesis and study of their reactivity in Suzuki-type cross-coupling reactions Tetrahedron 2006, 62, 11734-11739 (Pubitemid 44696283)
-
(2006)
Tetrahedron
, vol.62
, Issue.50
, pp. 11734-11739
-
-
Voisin, A.S.1
Bouillon, A.2
Berenguer, I.3
Lancelot, J.-C.4
Lesnard, A.5
Rault, S.6
-
31
-
-
30544445259
-
Synthesis of ortho-cyanopyridylboronic acids and esters toward cyano-functionalized bipyridines
-
DOI 10.1055/s-2005-922772, G33905ST
-
Cailly, T.; Fabis, F.; Bouillon, A.; Lemaitre, S.; Sopkova-de Oliveira Santos, J.; Rault, S. Synthesis of orthocyanopyridylboronic acids and esters toward obtention of cyanofunctionnalized bipyridines Synlett 2006, 1, 53-56 (Pubitemid 43082387)
-
(2006)
Synlett
, Issue.1
, pp. 53-56
-
-
Cailly, T.1
Fabis, F.2
Bouillon, A.3
Lemaitre, S.4
Sopkova, J.5
De Santos, O.6
Rault, S.7
-
32
-
-
79960598849
-
Design and Synthesis of thienylpyridyl garlands as non-peptidic alpha helix mimetics and potential protein-protein interactions disruptors
-
De Giorgi, M.; Voisin-Chiret, A. S.; Sopkova-de Oliveira Santos, J.; Corbo, F.; Franchini, C.; Rault, S. Design and Synthesis of thienylpyridyl garlands as non-peptidic alpha helix mimetics and potential protein-protein interactions disruptors Tetrahedron 2011, 67, 6145-6154
-
(2011)
Tetrahedron
, vol.67
, pp. 6145-6154
-
-
De Giorgi, M.1
Voisin-Chiret, A.S.2
Sopkova-De Oliveira Santos, J.3
Corbo, F.4
Franchini, C.5
Rault, S.6
-
33
-
-
57349119776
-
A general synthesis of halo-oligopyridines. The Garlanding concept
-
Voisin-Chiret, A. S.; Bouillon, A.; Burzicki, G.; Célant, M.; Legay, R.; El-Kashef, H.; Rault, S. A general synthesis of halo-oligopyridines. The Garlanding concept Tetrahedron 2009, 65, 607-612
-
(2009)
Tetrahedron
, vol.65
, pp. 607-612
-
-
Voisin-Chiret, A.S.1
Bouillon, A.2
Burzicki, G.3
Célant, M.4
Legay, R.5
El-Kashef, H.6
Rault, S.7
-
34
-
-
77955403097
-
Synthesis of New [2,3′:6′,3″]Terpyridines Using Iterative Cross-Coupling Reactions
-
Burzicki, G.; Voisin-Chiret, A. S.; Sopková-de Oliveira Santos, J.; Rault, S. Synthesis of New [2,3′:6′,3″]Terpyridines Using Iterative Cross-Coupling Reactions Synthesis 2010, 16, 2804-2810
-
(2010)
Synthesis
, vol.16
, pp. 2804-2810
-
-
Burzicki, G.1
Voisin-Chiret, A.S.2
Sopková-De Oliveira Santos, J.3
Rault, S.4
|