Outpatient consolidation treatment with clofarabine in a phase 2 study of older adult patients with previously untreated acute myelogenous leukemia

Leukemia and Lymphoma

Volumn 53, Issue 3, 2012, Pages 435-440

  Claxton, David ^a   Erba, Harry P ^b   Faderl, Stefan ^c   Arellano, Martha ^d   Lyons, Roger M ^e   Kovacsovics, Tibor ^f   Gabrilove, Janice ^g   Huebner, Dirk ^h   Gandhi, Pritesh J ^h   Kantarjian, Hagop ^c  

^a PENN STATE CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d EMORY UNIVERSITY   (United States)

^e Developmental Therapeutics Committee and Co Chair of the Genitourinary Committee   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h GENZYME CORPORATION   (United States)

Author keywords

Acute myelogenous leukemia; Clofarabine; Outpatient administration

Indexed keywords

CLOFARABINE;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELLULITIS; CONSOLIDATION CHEMOTHERAPY; DECREASED APPETITE; DIARRHEA; DRUG FATALITY; DYSPNEA; EDEMA; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; GERIATRICS; HEADACHE; HOSPITALIZATION; HUMAN; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOXIA; INSOMNIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; OUTPATIENT; PNEUMONIA; PRIORITY JOURNAL; RASH; SEPSIS; SIDE EFFECT; STAPHYLOCOCCUS INFECTION; THROMBOCYTOPENIA; TREATMENT OUTCOME; URINARY TRACT INFECTION; VOMITING;

ACUTE KIDNEY INJURY; ADENINE NUCLEOTIDES; AGED; AMBULATORY CARE; ANTIMETABOLITES, ANTINEOPLASTIC; ARABINONUCLEOSIDES; CONSOLIDATION CHEMOTHERAPY; DRUG ADMINISTRATION SCHEDULE; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; HYPOKALEMIA; INPATIENTS; LENGTH OF STAY; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; NEUTROPENIA; OUTPATIENTS; PNEUMONIA; QUALITY OF LIFE;

EID: 84857531543     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.616960     Document Type: Article

References (20)

1. A ppelbaum FR, Gundacker H, Head DR., et al. Age and acute myeloid leukemia. Blood 2006;107:3481-3485.
2. B üc hner T, Berdel WE, Haferlach C., et al. Age-related risk profi le and chemotherapy dose response in acute myeloid leukemia:a study by the German Acute Myeloid Leukemia Cooperative Group. J. Clin. Oncol. 2009;27:61-69.
3. Estey E. Acute myeloid leukemia and myelodysplastic syndromes in older patients. J. Clin. Oncol. 2007;25:1908-1915. (Pubitemid 46854425)
4. L ö w enberg B, Suciu S, Archimbaud E., et al. Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy-the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: Fi nal report. European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative Hovon Group. J. Clin. Oncol. 1998;16:872-881. (Pubitemid 28115455)
5. R owe JM, Neuberg D, Friedenberg W., et al. A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: A trial by the Eastern Cooperative Oncology Group. Blood 2004;103:479-485. (Pubitemid 38140076)
6. Larson ML, Venugopal P. Clofarabine:a new treatment option for patients with acute myeloid leukemia. Expert Opin Pharmacother 2009;10:1353-1357.
7. K antarjian HM, Jeha S, Gandhi V., et al. Clofarabine: Past, present, and future. Leuk Lymphoma 2007;48:1922-1930.
8. Mayer RJ, Davis RB, Schiff er CA., et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. N. Engl. J. Med. 1994;331:896-903. (Pubitemid 24299870)
9. C ox KM, Goel S, O' C onnell RL., et al. A randomized crossover trial comparing inpatient and outpatient administration of high dose cisplatin. Intern Med J 2010 Feb 26. [Epub ahead of print] .
10. Halim TY, Song KW, Barnett MJ., et al. Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann. Oncol. 2007;18:1246-1252. (Pubitemid 47244373)
11. Gardin C, Turlure P, Fagot T., et al. Postremission treatment of elderly patients with acute myeloid leukemia in fi rst complete remission after intensive induction chemotherapy: Results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial. Blood 2007;109:5129-5135. (Pubitemid 46900774)
12. G ó mez-Almaguer D, Ruiz-Arg ü elles GJ, Ruiz-Arg ü elles A., et al. Hematopoietic stem cell allografts using a non-myeloablative conditioning regimen can be safely performed on an outpatient basis: Report of four cases. Bone Marrow Transplant 2000;25:131-133. (Pubitemid 30087980)
13. Yamazaki K, Boku N, Shibamoto K., et al. Th e role of the outpatient clinic in chemotherapy for patients with unresectable or recurrent gastric cancer. Jpn J. Clin. Oncol. 2007;37:96-101. (Pubitemid 47090706)
14. Gillis S, Dann EJ, Rund D. Selective discharge of patients with acute myeloid leukemia during chemotherapy-induced neutropenia. Am. J. Hematol. 1996;51:26-31. (Pubitemid 26039994)
15. Zhenchuk A, Lotfi K, Juliusson G., et al. Mechanisms of anticancer action and pharmacology of clofarabine. Biochem Pharmacol 2009;78:1351-1359.
16. K antarjian HM, Erba HP, Claxton D., et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J. Clin. Oncol. 2010;28:549-555.
17. B urnett AK, Russell NH, Kell J., et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J. Clin. Oncol. 2010;28:2389-2395.
18. Dressel A, Kwari M, McGreal AM. Nursing considerations for optimal outpatient management of adult patients with leukemia treated with clofarabine Clin J Oncol Nurs 2011;15:E13-E23.
19. G irmenia C, Alimena G, Latagliata R., et al. Out-patient management of acute myeloid leukemia after consolidation chemotherapy. Role of a hematologic emergency unit. Haematologica 1999;84:814-819. (Pubitemid 29474371)
20. R ose PG, Lappas PT. Analysis of the cost effectiveness of concurrent cisplatin-based chemoradiation in cervical cancer: Implications from five randomized trials. Gynecol Oncol 2000; 78:3-6. (Pubitemid 30439469)