The effects of topical sildenafil on wound healing in rat

Iranian Journal of Pharmaceutical Sciences

Volumn 7, Issue 1, 2011, Pages 43-48

  Jamshidzadeh, Akram ^a   Azarpira, Negar ^b  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Nitric oxide; Sildenafil cream; Wound healing

Indexed keywords

COLLAGEN; SILDENAFIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFECT; EPITHELIZATION; FIBROBLAST; HISTOPATHOLOGY; MACROPHAGE; MALE; NONHUMAN; RAT; REGENERATION; VASCULARIZATION; WOUND HEALING;

EID: 84857521621     PISSN: 17352444     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ayyildiz A, Turgay AkGul K, Nuhoglu B, Huri E, Cayadere M, Ustun H, Germyanoglu C. An experimental study: does topically Applied sildenafil citrate (sildegra) have an effect on the preservation of c of the graft in fullthickness tubed free skin grafts. Turk J Med Sci 2006; 36: 343-8.
2. Gross GJ. Sildenafil and endothelial dysfunction in humans. Circulation 2005; 111: 721-3.
3. Halcox JP, Nour KR, Zalos G, Mincemoyer RA, Waclawiw M, Rivera CE, REST OF THE AUTHORS. The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia. J Am Coll Cardiol 2002; 40: 1232-40.
4. Hryniewicz K, Dimayuga C, Hudaihed A, Androne AS, Zheng H, Jankowski K, REST OF THE AUTHORS. Inhibition of angiotensinconverting enzyme and phosphodiesterase type 5 improves endothelial function in heart failure. Clin Sci (London) 2005; 108: 331-8.
5. Kimura M, Higashi Y, Hara K, Noma K, Sasaki S, Nakagawa K, REST OF THE AUTHORS. PDE5 inhibitor sildenafil citrate augments endothelium dependent vasodilation in smokers. Hypertension 2003; 41: 1106-10.
6. Aydin A, Orhan H, Sayal A, Ozata M, Sahin G, Isimer A. Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control. Clin Biochem 2001; 34: 65-70.
7. Weller R, Finnen MJ. The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice. Nitric Oxide 2006; 15: 395-9.
8. Bauer JA, Rao W, Smith DJ. Evaluation of linear polyethyleneimine/ nitric oxide adduct on wound repair: therapy versus toxicity. Wound Repair Regen 1998; 6: 569-77.
9. Masters KS, Leibovich SJ, Belem P, West JL, Poole-Warren LA. Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice. Wound Repair Regen 2002; 10: 286-94.
10. Rendell MS, Johnson ML, Smith D, Finney D, Capp C, Lammers R, Lancaster S. Skin blood flow response in the rat model of wound healing: expression of vasoactive factors. J Surg Res 2002; 107: 18-26.
11. Rockville MD. US pharmacopeial convention, Inc. 2004; 2345-9.
12. Haihong Li, Xiaobing Fu, Zhang L, Huang Q, Zhigu Wu, Sun T. Research of PDGF-BB gel on the wound healing of diabetic rats and its pharmacodynamics. J Surg Res 2008; 145: 41-8.
13. Qiu Z, Kwon AH, Kamiyama Y. Effects of plasma fibronectin on the healing of full-thickness skin wounds in streptozotocin-induced diabetic rats. J Surg Res. 2007; 138: 64-70.
14. Mandeep Kaushal N, Gopalan Kutty C, Rao M. Wound healing activity of NOE-aspirin: a preclinical study. Nitric Oxide 2007; 16: 150-6.
15. Austin JC. Editorial: inducible nitric oxide synthase in wound healing. The J Urol 2004; 171: 1948.
16. Richard HL, Efron D, Tantry U, Barbul A. Nitric oxide in the healing wound: A time-course study. J Surg Res 2001; 101: 104-8.
17. Serarslan G, Altug E, Kontas T, Atik E, Avcit G. Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress. Clin Exper Dermatol 2007; 32: 709-15.
18. Amadeu TP, Amedea BS, Deoliveira MG, Monte- Alto-Costa A. Nitric oxide donor improves healing if applied on inflammatory and proliferative phase. J Surg Res 2007; 10: 5.
19. Shekhte AB, Serezhenkov VA, Rudenko TG, Pekshev AV, Vanin AF. Beneficial effect of gaseous nitric oxide on the healing of skin wounds. Nitric Oxide 2005; 12: 210-9.
20. Sarifakioglu N, Gokrem S, Ates L, Akbuga UB, Aslan G. The influence of sildenafil on random skin flap survival in rats: an experimental study. Br Association Plastic Surg 2004; 57: 769-72.
21. Gertner E. Treatment with sildenafil for the healing of refractory skin ulcerations in the antiphospholipid syndrome. Lupus 2003; 12: 133.
22. Schwentker A, Vodovotz Y, Weller R, Billiar TR. Nitric oxide and wound repair: Role of Cytokines. Nitric oxide 2002; 7: 1.
23. Brueckner CS, Becker MO, Kroencke T, Huscher D, Scherer HU, Worm M, Burmester G, Riemekasten G. Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study. Ann Rheum Dis 2010; 69: 1475-8.
24. Derici H, Kamer E, Unalp HR, Diniz G, Bozdag AD, Tansug T, Ortac R, Erbil Y. Effect of sildenafil on wound healing: An experimental study. Langenbecks Arch Surg 2010; 395: 713-8.