Caffeic acid phenetyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress

Clinical and Experimental Dermatology

Volumn 32, Issue 6, 2007, Pages 709-715

  Serarslan, G ^a,c   Altug E ^a   Kontas, T ^a   Atik, E ^a   Avci, G ^b  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

^b AFYON KOCATEPE UNIVERSITY   (Turkey)

^c NONE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CAFFEIC ACID PHENETHYL ESTER; GLUTATHIONE; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; CAFFEIC ACID DERIVATIVE; DRUG DERIVATIVE; PHENETHYL ALCOHOL; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; HISTOPATHOLOGY; INCISION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SKIN INCISION; SUTURING METHOD; WOUND HEALING; ANIMAL; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; INJURY; METABOLISM; PATHOLOGY; SKIN; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CAFFEIC ACIDS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FREE RADICAL SCAVENGERS; GLUTATHIONE; MALE; MALONDIALDEHYDE; NITRIC OXIDE; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SKIN; SUPEROXIDE DISMUTASE; WOUND HEALING;

EID: 35349027757     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2007.02470.x     Document Type: Article

References (25)

1. Cotran RS, Kumar V et al. Inflammation and repair. In : Robbins Pathologic Basis of Disease (Cotran RS, Kumar V, Robbins SL, Schoen FJ, eds), 5th edn. Philadelphia : W.B. Saunders, 1994 : 51 92.
2. Gupta A, Singh RL, Roghubir R. Antioxidant status during cutaneous wound healing in immunocompromised rats. Mol Cell Biochem 2002 241 : 1 7.
3. Russo A, Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002 73 : S21 9.
4. Frei B. Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med 1994 97 : 5S 13S.
5. Shukla A, Rasik AM, Patnaik GK. Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defence enzymes in a healing cutaneous wound. Free Radic Res 1997 26 : 93 101.
6. Musalmah M, Fairuz AH, Gapor MT et al. Effect of vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats. Asia Pacific J Clin Nurt 2002 11 : S448 51.
7. Suguna L, Singh S, Sivakumar P et al. Influence of Terminalia chebula on dermal woung healing in rats. Phytother Res 2002 16 : 227 31.
8. Sud'ina GF, Mirzoeva OK, Pushkareva MA et al. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett 1993 326 : 21 4.
9. Khayyal MT, el-Ghazaly MA, el-Khatib AS. Mechanisms involved in the antiinflammatory effect of propolis extract. Drugs Exp Clin Res 1993 19 : 197 203.
10. Natarajan K, Gingh S, Burke TR et al. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription NF-κ B. Proc Natl Acad Sci USA 1996 93 : 9090 5.
11. Pascual C, Gonzalez R, Torricella RG. Scavenging action of propolis extract against oxygen radicals. J Ethnopharmacol 1994 41 : 9 13.
12. Weichselbaum TE. An accurate and rapid method for the determination in small amounts of blood serum and plasma. Am J Clin Pathol 1949 10 : 40 9.
13. Yoshioka T, Kawada K, Shimada T et al. Lipid peroxidation in maternal and cord blood and protective mechanism aganist activated-oxygen toxicity in the blood. Am J Obstet Gynecol 1979 135 : 372 6.
14. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990 36 : 1440 3.
15. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutatione. J Laboratory Clin Med 1963 61 : 882 8.
16. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988 34 : 497 500.
17. Aebi H. Catalase. In : Methods of Enzymatic Analysis (Bergmeyer HU, ed.). Academic Press, 1984 : 673 84.
18. Romero FJ, Bosch-Morell F, Romero MJ et al. Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 1998 106 : 1229 34.
19. Hosnuter M, Gurel A, Babuccu O et al. The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury. Burns 2004 30 : 121 5.
20. Ozyurt H, Irmak MK, Akyol O et al. Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischaemia- reperfusion injury. Cell Biochem Funct 2001 19 : 259 63.
21. Yamasaki K, Edington HDJ, McClosky C et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998 101 : 967 71.
22. Benrath J, Zimmermann M, Gillardon F. Substance P and nitric oxide mediate wound healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation. Neurosci Lett 1995 200 : 17 20.
23. Wright E, Scism-Bacon JL, Glass LC. Oxidative stres in type 2 diabetes: the role of fasting and postprandial glycaemia. Int J Clin Pract 2006 60 : 308 14.
24. Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med 1999 27 : 922 35.
25. Koltuksuz U, Mutus HM, Kutlu R et al. Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats. J Pediatr Surg 2001 36 : 1504 9.