Exercise-Induced Cardiac Remodeling

Progress in Cardiovascular Diseases

Volumn 54, Issue 5, 2012, Pages 380-386

  Weiner, Rory B ^a   Baggish, Aaron L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATHLETE; CARDIOMEGALY; DIASTOLE; ECHOCARDIOGRAPHY; EXERCISE; EXERCISE INDUCED CARDIAC REMODELING; HEART ATRIUM ENLARGEMENT; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; HEART OUTPUT; HEART RATE; HEART RIGHT VENTRICLE HYPERTROPHY; HUMAN; MYOPATHY; RECREATION; SYSTOLE;

ADAPTATION, PHYSIOLOGICAL; ATHLETES; EXERCISE; HEART VENTRICLES; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; PHYSICAL ENDURANCE; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84857516611     PISSN: 00330620     EISSN: 18731740     Source Type: Journal    
DOI: 10.1016/j.pcad.2012.01.006     Document Type: Article

References (72)

1. Henschen S. Skidlauf und Skidwettlauf. Eine medizinische Sportstudie. Mitt Med Klin Upsala 1899, 2.
2. Darling E.A. The effects of training. A study of the Harvard University crews. Boston Med Surg J 1899, CXLI:229-233.
3. Roskamm H., Reindell H., Musshoff K., et al. Relations between heart size and physical efficiency in male and female athletes in comparison with normal male and female subjects. Arch Kreislaufforsch 1961, 35:67-102.
4. Reindell H., Roskamm H., Steim H. The heart and blood circulation in athletes. Med Welt 1960, 31:1557-1563.
5. Bulychev V.V., Khmelevskii V.A., Rutman Iu.V. Roentgenological and instrumental examination of the heart in athletes. Klin Med 1965, 43:108-114.
6. Rowell L.B. Human circulation: regulation during physical stress 1986, Oxford University Press, New York, NY.
7. Jose A.D., Collison D. The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res 1970, 4:160-167.
8. Uusitalo A.L., Uusitalo A.J., Rusko H.K. Exhaustive endurance training for 6-9 weeks did not induce changes in intrinsic heart rate and cardiac autonomic modulation in female athletes. Int J Sports Med 1998, 19:532-540.
9. Maron B.J., Zipes D.P. Introduction: eligibility recommendations for competitive athletes with cardiovascular abnormalities-general considerations. J Am Coll Cardiol 2005, 45:1318-1321.
10. Roeske W.R., O'Rourke R.A., Klein A., et al. Noninvasive evaluation of ventricular hypertrophy in professional athletes. Circulation 1976, 53:286-291.
11. Pelliccia A., Culasso F., Di Paolo F.M., et al. Physiologic left ventricular cavity dilatation in elite athletes. Ann Intern Med 1999, 130:23-31.
12. Pelliccia A., Maron B.J., Spataro A., et al. The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. N Engl J Med 1991, 324:295-301.
13. Sharma S., Maron B.J., Whyte G., et al. Physiologic limits of left ventricular hypertrophy in elite junior athletes: relevance to differential diagnosis of athlete's heart and hypertrophic cardiomyopathy. J Am Coll Cardiol 2002, 40:1431-1436.
14. Baggish A.L., Yared K., Weiner R.B., et al. Differences in cardiac parameters among elite rowers and subelite rowers. Med Sci Sports Exerc 2010, 42:1215-1220.
15. Morganroth J., Maron B.J., Henry W.L., et al. Comparative left ventricular dimensions in trained athletes. Ann Intern Med 1975, 82:521-524.
16. Fisman E.Z., Pelliccia A., Motro M., et al. Effect of intensive resistance training on isotonic exercise Doppler indexes of left ventricular systolic function. Am J Cardiol 2002, 89:887-891.
17. Roy A., Doyon M., Dumesnil J.G., et al. Endurance vs. strength training: comparison of cardiac structures using normal predicted values. J Appl Physiol 1988, 64:2552-2557.
18. Pluim B.M., Zwinderman A.H., van der Laarse A., et al. The athlete's heart. A meta-analysis of cardiac structure and function. Circulation 2000, 101:336-344.
19. Baggish A.L., Wang F., Weiner R.B., et al. Training-specific changes in cardiac structure and function: a prospective and longitudinal assessment of competitive athletes. J Appl Physiol 2008, 104:1121-1128.
20. Spence A.L., Naylor L.H., Carter H.H., et al. A prospective randomised longitudinal MRI study of left ventricular adaptation to endurance and resistance exercise training in humans. J Physiol 2011, 589:5443-5452.
21. Fagard R., Aubert A., Staessen J., et al. Cardiac structure and function in cyclists and runners. Comparative echocardiographic study. Br Heart J 1984, 52:124-129.
22. Bar-Shlomo B.Z., Druck M.N., Morch J.E., et al. Left ventricular function in trained and untrained healthy subjects. Circulation 1982, 65:484-488.
23. Bekaert I., Pannier J.L., Van de Weghe C., et al. Non-invasive evaluation of cardiac function in professional cyclists. Br Heart J 1981, 45:213-218.
24. Douglas P.S., O'Toole M.L., Hiller W.D., et al. Left ventricular structure and function by echocardiography in ultraendurance athletes. Am J Cardiol 1986, 58:805-809.
25. Gilbert C.A., Nutter D.O., Felner J.M., et al. Echocardiographic study of cardiac dimensions and function in the endurance-trained athlete. Am J Cardiol 1977, 40:528-533.
26. Abergel E., Chatellier G., Hagege A.A., et al. Serial left ventricular adaptations in world-class professional cyclists: implications for disease screening and follow-up. J Am Coll Cardiol 2004, 44:144-149.
27. Richand V., Lafitte S., Reant P., et al. An ultrasound speckle tracking (two-dimensional strain) analysis of myocardial deformation in professional soccer players compared with healthy subjects and hypertrophic cardiomyopathy. Am J Cardiol 2007, 100:128-132.
28. Cardim N., Oliveira A.G., Longo S., et al. Doppler tissue imaging: regional myocardial function in hypertrophic cardiomyopathy and in athlete's heart. J Am Soc Echocardiogr 2003, 16:223-232.
29. Baggish A.L., Yared K., Wang F., et al. The impact of endurance exercise training on left ventricular systolic mechanics. Am J Physiol 2008, 295:H1109-H1116.
30. Weiner R.B., Hutter A.M., Wang F., et al. The impact of endurance exercise training on left ventricular torsion. JACC Cardiovasc Imaging 2010, 3:1001-1009.
31. Naylor L.H., Arnolda L.F., Deague J.A., et al. Reduced ventricular flow propagation velocity in elite athletes is augmented with the resumption of exercise training. J Physiol 2005, 563:957-963.
32. Caso P., D'Andrea A., Galderisi M., et al. Pulsed Doppler tissue imaging in endurance athletes: relation between left ventricular preload and myocardial regional diastolic function. Am J Cardiol 2000, 85:1131-1136.
33. Tumuklu M.M., Ildizli M., Ceyhan K., et al. Alterations in left ventricular structure and diastolic function in professional football players: assessment by tissue Doppler imaging and left ventricular flow propagation velocity. Echocardiography 2007, 24:140-148.
34. Prasad A., Popovic Z.B., Arbab-Zadeh A., et al. The effects of aging and physical activity on Doppler measures of diastolic function. Am J Cardiol 2007, 99:1629-1636.
35. D'Andrea A., Cocchia R., Riegler L., et al. Left ventricular myocardial velocities and deformation indexes in top-level athletes. J Am Soc Echocardiogr 2010, 23:1281-1288.
36. Hauser A.M., Dressendorfer R.H., Vos M., et al. Symmetric cardiac enlargement in highly trained endurance athletes: a two-dimensional echocardiographic study. Am Heart J 1985, 109:1038-1044.
37. Henriksen E., Landelius J., Wesslen L., et al. Echocardiographic right and left ventricular measurements in male elite endurance athletes. Eur Heart J 1996, 17:1121-1128.
38. Scharhag J., Schneider G., Urhausen A., et al. Athlete's heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging. J Am Coll Cardiol 2002, 40:1856-1863.
39. D'Andrea A., Riegler L., Golia E., et al. Range of right heart measurements in top-level athletes: the training impact. Int J Cardiol 2011.
40. Kim J.H., Noseworthy P.A., McCarty D., et al. Significance of electrocardiographic right bundle branch block in trained athletes. Am J Cardiol 2011, 107:1083-1089.
41. Scharf M., Brem M.H., Wilhelm M., et al. Cardiac magnetic resonance assessment of left and right ventricular morphologic and functional adaptations in professional soccer players. Am Heart J 2010, 159:911-918.
42. Hoglund C. Enlarged left atrial dimension in former endurance athletes: an echocardiographic study. Int J Sports Med 1986, 7:133-136.
43. Pelliccia A., Maron B.J., Di Paolo F.M., et al. Prevalence and clinical significance of left atrial remodeling in competitive athletes. J Am Coll Cardiol 2005, 46:690-696.
44. D'Andrea A., Riegler L., Cocchia R., et al. Left atrial volume index in highly trained athletes. Am Heart J 2010, 159:1155-1161.
45. Hoogsteen J., Hoogeveen A., Schaffers H., et al. Left atrial and ventricular dimensions in highly trained cyclists. Int J Cardiovasc Imaging 2003, 19:211-217.
46. Wilhelm M., Roten L., Tanner H., et al. Atrial remodeling, autonomic tone, and lifetime training hours in nonelite athletes. Am J Cardiol 2011, 108:580-585.
47. Pelliccia A., Thompson P.D. The genetics of left ventricular remodeling in competitive athletes. J Cardiovasc Med (Hagerstown) 2006, 7:267-270.
48. Pelliccia A., Maron B.J., Culasso F., et al. Athlete's heart in women. Echocardiographic characterization of highly trained elite female athletes. JAMA 1996, 276:211-215.
49. George K.P., Wolfe L.A., Burggraf G.W., et al. Electrocardiographic and echocardiographic characteristics of female athletes. Med Sci Sports Exerc 1995, 27:1362-1370.
50. Sun B., Ma J.Z., Yong Y.H., et al. The upper limit of physiological cardiac hypertrophy in elite male and female athletes in China. Eur J Appl Physiol 2007, 101:457-463.
51. Whyte G.P., George K., Nevill A., et al. Left ventricular morphology and function in female athletes: a meta-analysis. Int J Sports Med 2004, 25:380-383.
52. Haykowsky M., Chan S., Bhambhani Y., et al. Effects of combined endurance and strength training on left ventricular morphology in male and female rowers. Can J Cardiol 1998, 14:387-391.
53. Rowland T., Roti M. Influence of sex on the "Athlete's Heart" in trained cyclists. J Sci Med Sport 2010, 13:475-478.
54. Basavarajaiah S., Boraita A., Whyte G., et al. Ethnic differences in left ventricular remodeling in highly-trained athletes relevance to differentiating physiologic left ventricular hypertrophy from hypertrophic cardiomyopathy. J Am Coll Cardiol 2008, 51:2256-2262.
55. Rawlins J., Carre F., Kervio G., et al. Ethnic differences in physiological cardiac adaptation to intense physical exercise in highly trained female athletes. Circulation 2010, 121:1078-1085.
56. Montgomery H.E., Clarkson P., Dollery C.M., et al. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 1997, 96:741-747.
57. Karjalainen J., Kujala U.M., Stolt A., et al. Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes. J Am Coll Cardiol 1999, 34:494-499.
58. Baggish A.L., Weiner R.B., Yared K., et al. Impact of family hypertension history on exercise-induced cardiac remodeling. Am J Cardiol 2009, 104:101-106.
59. Heineke J., Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 2006, 7:589-600.
60. Brancaccio M., Fratta L., Notte A., et al. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 2003, 9:68-75.
61. Heineke J., Ruetten H., Willenbockel C., et al. Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc Natl Acad Sci U S A 2005, 102:1655-1660.
62. Zou Y., Akazawa H., Qin Y., et al. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol 2004, 6:499-506.
63. Moritz F. Uber orthodiagraphische Untersuchungen am Herzen. Med Wochenschr 1902, 49.
64. La Gerche A., Burns A.T., Mooney D.J., et al. Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J 2011, December 6 [Epub ahead of print].
65. Harper R.W., Mottram P.M. Exercise-induced right ventricular dysplasia/cardiomyopathy-an emerging condition distinct from arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Lung Circ 2009, 18:233-235.
66. Pelliccia A., Kinoshita N., Pisicchio C., et al. Long-term clinical consequences of intense, uninterrupted endurance training in olympic athletes. J Am Coll Cardiol 2010, 55:1619-1625.
67. Sarna S., Sahi T., Koskenvuo M., et al. Increased life expectancy of world class male athletes. Med Sci Sports Exerc 1993, 25:237-244.
68. Karvonen M.J., Klemola H., Virkajarvi J., et al. Longevity of endurance skiers. Med Sci Sports 1974, 6:49-51.
69. Taioli E. All causes of mortality in male professional soccer players. Eur J Public Health 2007, 17:600-604.
70. Waterbor J., Cole P., Delzell E., et al. The mortality experience of major-league baseball players. N Engl J Med 1988, 318:1278-1280.
71. Blair S.N., Kohl H.W., Paffenbarger R.S., et al. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 1989, 262:2395-2401.
72. Williams P.T. Physical fitness and activity as separate heart disease risk factors: a meta-analysis. Med Sci Sports Exerc 2001, 33:754-761.