Insulin induces internalization of the plasma membrane 5- hydroxytryptamine2A (5-HT2A) receptor in the isolated human endothelium-denuded saphenous vein via the phosphatidylinositol 3-kinase pathway

Journal of Pharmacological Sciences

Volumn 118, Issue 2, 2012, Pages 178-185

  Kanai, Tasuku ^a   Kuwabara, Masachika ^b   Tanaka Totoribe, Naoko ^a   Nakamura, Eisaku ^c   Matsuo, Yasuko ^a   Gamoh, Shuji ^a   Suzuki, Akito ^a   Asada, Yujiro ^d   Hisa, Hiroaki ^a   Yamamoto, Ryuichi ^a  

^a KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b Kuwabara Clinic   (Japan)

^c Nobeoka Prefectural Hospital   (Japan)

^d UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Diabetes mellitus (DM); Insulin induced vasorelaxation; Nitric oxide (NO); Saphenous vein (SV)

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOPHANE INSULIN; MEMBRANE RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SERINE; SEROTONIN; SEROTONIN 2 RECEPTOR; WORTMANNIN;

ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DRUG EFFECT; ENDOTHELIUM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN TISSUE; INTERNALIZATION; PROTEIN EXPRESSION; SAPHENOUS VEIN; SIGNAL TRANSDUCTION; VASCULAR RING; VASODILATATION; VENOCONSTRICTION;

EID: 84857510205     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11172FP     Document Type: Article

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