Lytic peptides with improved stability and selectivity designed for cancer treatment

Journal of Pharmaceutical Sciences

Volumn 101, Issue 4, 2012, Pages 1508-1517

  Chen, Long ^a   Tu, Zhigang ^a   Voloshchuk, Natalya ^a   Liang, Jun F ^a  

^a Stevens Institute of Technology   (United States)

Author keywords

Acid activation; Cancer; Formulation; Histidine rich peptides; Macromolecular drug delivery; Multi drug resistance; Peptide aggregates; PH; Solvation; Stability

Indexed keywords

LYTIC PEPTIDE; PEPTIDE; PEPTIDE DERIVATIVE; PTP 7; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CELL KILLING; CELL MEMBRANE; CYTOLYSIS; CYTOTOXICITY; DISSOLUTION; HALF LIFE TIME; HUMAN; HUMAN CELL; LIPID BILAYER; PEPTIDE AGGREGATION; PH; PROTEIN BINDING; PROTEIN STRUCTURE; SOLID TUMOR;

EID: 84857504892     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23043     Document Type: Article

References (29)

1. Sauna ZE, Smith MM, Muller M, Kerr KM, Ambudkar SV. 2001. The mechanism of action of multidrug-resistance-linked P-glycoprotein. J Bioenerg Biomembr 33:481-491.
2. Yu DK. 1999. The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions. J Clin Pharmacol 39:1203-1211.
3. Roepe PD. 1995. The role of the MDR protein in altered drug translocation across tumor cell membranes. Biochim Biophys Acta 1241:385-405.
4. Eliassen LT, Berg G, Sveinbjørnsson B, Vorland L, Svendsen JS, Rekdal Ø. 2002. Evidence for direct antitumor mechanism of action by bovine lactoferricin. Anticancer Res 22:2703-2710.
5. Shin SY, Kang JH, Hahm KS. 1999. Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melitin hybrid peptides. J Pept Res 53:82-90.
6. Shin SY, Kang JH, Jang SY, Kim Y, Kim KL, Hahm K. 2000. Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells. Biochim Biophys Acta 1463:209-218.
7. Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI. 2001. Antibacterial, antitumor and hemolytic activities of alphahelical antibiotic peptide, P18 and its analogs. J Pept Res 58:504-514.
8. Yang N, Steven W, Steven JS, Rekdal Q. 2002. Enhanced anti-tumor activity and selectivity of lactoferrin-derived peptides. J Pept Res 60:187-197.
9. Zaleska M, Bodek G, Jana B, Hansel W, Ziecik AJ. 2003. Targeted destruction of normal and cancer cells through lutropin/choriogonadotropin receptors using hecate-betaCG conjugate. Exp Clin Endocrinol Diabetes 111:146-153.
10. Leuschner C, Enright FM, Gawronska B, Hansel W. 2003. Membrane disrupting lytic peptide conjugates destroy hormone dependent and independent breast cancer cells in vitro and in vivo. Breast Cancer Res Treat 78:17-27.
11. Raghunand N, He X, van Sluis R, Mahoney B, Baggett B, Taylor CW, Paine-Murrieta G, Roe D, Bhujwalla ZM, Gillies RJ. 1999. Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer 80:1005-1011.
12. Engin K, Leeper DB, Cater JR, Thistlethwaite AJ, Tupchong L, McFarlane JD. 1995. Extracellular pH distribution in human tumours. Int J Hyperthermia 11:211-216.
13. Tu Z, Young A, Murphy C, Liang JF. 2009. The pH sensitivity of histidine-containing lytic peptides. J Pept Sci 15:790-795.
14. Tu Z, Volk M, Shah K, Clerkin K, Liang JF. 2009. Constructing bioactive peptides with pH-dependent activities. Peptides 30:1523-1528.
15. Henriques ST, Pattenden LK, Aguilar MI, Castanho MARB. 2008. PrP(106-126) does not interact with membranes under physiological conditions. Biophys J 95:1877-1889.
16. Sherman PJ, Jackway RJ, Gehman JD, Praporski S, McCubbin GA, Mechler A, Martin LL, Separovic F, Bowie JH. 2009. Solution structure and membrane interactions of the antimicrobial peptide fallaxidin 4.1a: An NMR and QCM study. Biochemistry 48:11892-11901.
17. Ricchelli F, Drago D, Filippi B, Tognon G, Zatta P. 2005. Aluminum-triggered structural modifications and aggregation of β-amyloids. Cell Mol Life Sci 62:1724-1733.
18. Wu C, Biancalana M, Koide S, Shea JE. 2009. Binding modes of thioflavin-T to the single-layer beta-sheet of the peptide self-assembly mimics. J Mol Biol 394:627-633.
19. Kim S, Kim SS, Lee BJ. 2005. Correlation between the activities of α-helical antimicrobial peptides and hydrophobicities represented as RP HPLC retention times. Peptides 26:2050-2056.
20. Kim S, Kim SS, Bang YJ, Kim SJ, Lee BJ. 2003. In vitro activities of native and designed peptide antibioticsagainst drug sensitive and resistant tumor cell lines. Peptides 24:945-953.
21. Wilson WW, Wade MM, Holman SC, Champlin FR. 2001. Status of methods for assessing bacterial cell surface charge properties based on zeta potential measurements. J Microbiol Meth 43:153-164.
22. Terzi E, Hölzemann G, Seelig J. 1997. Interaction of Alzheimer betaamyloid peptide(1-40) with lipid membranes. Biochem 38:14845-14852.
23. Bertsch M, Mayburd AL, Kassner RJ. 2003. The identification of hydrophobic sites on the surface of proteins using absorption difference spectroscopy of bromophenol blue. Anal Biochem 313:187-195.
24. Green BD, Gault VA, Mooney MH, Irwin N, Harriott P, Greer B, Bailey CJ, O'Harte FP, Flatt PR. 2004. Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues. Biol Chem 385:169-177.
25. Heck T, Limbach M, Geueke B, Zacharias M, Gardiner J, Kohler HP, Seebach D. 2006. Enzymatic degradation of beta- and mixed alpha, beta-oligopeptides. Chem Biodivers 3:1325-1348.
26. Janek K, Rothemund S, Gast K, Beyermann M, Zipper J, Fabian H, Bienert M, Krause E. 2001. Study of the conformational transition of A beta (1-42) using D-amino acid replacement analogues. Biochemistry 40:5457-5463.
27. Li J, Kao WJ. 2003. Synthesis of polyethylene glycol (PEG) derivatives and PEGylated-peptide biopolymer conjugates. Biomacromolecules 4:1055-1067.
28. Ricci M, Giovagnoli S, Blasi P, Schoubben A, Perioli L, Rossi C. 2006. Development of liposomal capreomycin sulfate formulations: Effects of formulation variables on peptide encapsulation. Int J Pharm 311:172-181.
29. Ibrahim MA, Ismail A, Fetouh MI, Gopferich A. 2008. Stability of insulin during the erosion of poly(lactic acid) and poly(lactic-co-glycolic acid) microspheres. J Control Release 106:241-252.